Topographically organized midbrain modulation of predatory and defensive aggression in the cat

Shaikh, Majid B.; Brutus, Martin; Siegel, Heidi E.; Siegel, Allan

doi:10.1016/0006-8993(85)90657-2

Cited by 32 publications

(6 citation statements)

References 12 publications

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“…Moreover, the activation of the central amygdala and lateral hypothalamus correlated significantly with the share of abnormal, predatory-like attacks in this model [22]. As the very same brain regions were shown to control predatory attacks in cats [1,[4][5][6], we proposed that antisocial-like aggressiveness in rats has a 'predatory dimension' as it regards both behavior and brain function. Unfortunately, however, the brain mechanisms of predatory aggression are less well known in rats than in cats.…”

Section: Introductionmentioning

confidence: 62%

“…This behavior is associated with minimal arousal, and does not involve social communication. These two forms of aggression are controlled by distinct neural circuits as shown by feline stimulation studies [4][5][6]. Based on phenomenological and physiological similarities, these types of aggressive behavior were proposed to be analogous with particular forms of psychopathological human aggression [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Tulogdi

Biró

Barsvári

et al. 2015

Behavioural Brain Research

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Our recent studies showed that brain areas that are activated in a model of escalated aggression overlap with those that promote predatory aggression in cats. This finding raised the interesting possibility that the brain mechanisms that control certain types of abnormal aggression include those involved in predation. However, the mechanisms of predatory aggression are poorly known in rats, a species that is in many respects different from cats. To get more insights into such mechanisms, here we studied the brain activation patterns associated with spontaneous muricide in rats. Subjects not exposed to mice, and those which did not show muricide were used as controls. We found that muricide increased the activation of the central and basolateral amygdala, and lateral hypothalamus as compared to both controls; in addition, a ventral shift in periaqueductal gray activation was observed.Interestingly, these are the brain regions from where predatory aggression can be elicited, or enhanced by electrical stimulation in cats. The analysis of more than 10 other brain regions showed that brain areas that inhibited (or were neutral to) cat predatory aggression were not affected by muricide. Brain activation patterns partly overlapped with those seen earlier in the cockroach hunting model of rat predatory aggression, and were highly similar with those observed in the glucocorticoid dysfunction model of escalated aggression. These findings show that the brain mechanisms underlying predation are evolutionarily conservative, and indirectly support our earlier assumption regarding the involvement of predation-related brain mechanisms in certain forms of escalated social aggression in rats.

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Section: Introductionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Tulogdi

Biró

Barsvári

et al. 2015

Behavioural Brain Research

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“…Projections from the dorsolateral and ventrolateral BNST to the lateral and medial hypothalamus and to brain stem nuclei are involved in agonistic behaviours, such as quiet biting attack (Shaikh et al, 1985;, and behaviours that are appetitive in nature (Glickman and Schiff, 1967). It is possible that activation (or inhibition) of such projections from the BNST could be involved in the initiation of the behaviours involved in relapse to drug-seeking, also an appetitive behaviour.…”

Section: Behaviours-significance For Of Stress-induced Relapsementioning

confidence: 99%

Stress-induced Relapse to Drug Seeking in the Rat; Role of the Bed Nucleus of the Stria Terminalis and Amygdala

Erb¹,

Shaham²,

Stewart³

2001

Stress

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There is growing interest in the role that the bed nucleus of the stria terminalis (BNST) and central nucleus of the amygdala (CeA), components of the extended amygdala, play in drug addiction. Within the BNST and CeA, there is an extensive system of intrinsic, primarily GABAergic, interconnections known to synthesize a variety of neuropeptides, including corticotrophin-releasing factor (CRF). The actions of CRF at extrahypothalamic sites,including the BNST and CeA, have been implicated in stress responses and in the aversive effects of withdrawal from drugs of abuse. Most recently, we have shown a critical role for extrahypothalamic CRF in stress-induced reinstatement of drug seeking in rats. In attempting to determine which brain circuitry mediates the effect of stress on relapse and, more specifically, where in the brain CRF acts to initiate the behaviours involved in relapse, we focused on the BNST and CeA. In the present paper, we summarize studies we have conducted that explore the role of these brain sites in stress-induced relapse to heroin and cocaine seeking, and then consider how our findings can be understood within the more general context of what is known about the role of the BNST and CeA in stress-related and general approach behaviours, such as drug seeking.

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“…Predatory aggression is associated with the lateral perifornical hypothalamus, ventral periaqueductal grey, and ventral and lateral tegmental areas (Shaikh, Brutus, Siegel, & Siegel, 1985).…”

Section: Resultsmentioning

confidence: 99%

Eight survival strategies in traumatic stress.

Valent¹

2007

Traumatology

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Posttraumatic stress disorder (PTSD) in its fourth criterion relies on the consequences of fight and flight survival responses. However, this limits understanding of a much wider variety of stress responses from other survival strategies. Information from a variety of disciplines suggests eight survival strategies including fight and flight. The anatomy, physiology, cognitions, emotions, and social expressions of these strategies are described in animals, and human infants and adults. A wider variety of survival strategies enriches conceptualization of PTSD and apparent comorbid phenomena.

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Topographically organized midbrain modulation of predatory and defensive aggression in the cat

Cited by 32 publications

References 12 publications

Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Stress-induced Relapse to Drug Seeking in the Rat; Role of the Bed Nucleus of the Stria Terminalis and Amygdala

Eight survival strategies in traumatic stress.

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