Topographical investigations on the climbing fiber inputs from forelimb and hindlimb afferents to the cerebellar anterior lobe

Jc, Eccles; Provini, L.; Strata, Piergiorgio; Táboríková, H

doi:10.1007/bf00235124

Cited by 85 publications

(22 citation statements)

References 25 publications

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“…In the same way that the CF projection from the forelimb dominates the pars intermedia of lobule V (Eccles et al 1968b; Provini et al 1968;Oscarsson, 1968;Leicht, Rowe & Schmidt, 1973), the trigeminal CF projection was found to predominate in H VI. The separation of the two areas, however, is not complete, and there is overlap of the forelimb projection on to H VI, and of the trigeminal projection on to the lateral margin of the pars intermedia.…”

Section: Pattern Of Projectionmentioning

confidence: 63%

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Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

Miles¹,

Wiesendanger²

1975

The Journal of Physiology

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SUMMARY1. In cats anaesthetized with pentobarbitone, the projection of climbing fibres (CFs) to the cerebellar cortex from trigeminal cutaneous branches and from the face area of the sensorimotor (SI) cortex was mapped, using the technique of laminar field potential analysis.2. The CF projections from both the trigeminal nerve and the SI face area were found to be localized to the same cerebellar folia, viz. chiefly the ipsilateral lobule HVI, with a small overlap on to the adjacent folia of lobule V and crus Ia of HVIIA. Frequently a projection from the superficial radial nerve to part or all of this area, was also found.3. A correspondence in the distribution and amplitudes of CF potentials evoked at most points by stimulation of the trigeminal nerve and the SI cortex was found. This implies a convergence of afferents from these two sources at or before the inferior olive.4. In more than half of the cats, a small area of the cerebellar hemisphere was found, in which contralateral as well as ipsilateral trigeminal stimulation would evoke CF potentials. Usually inputs from the superficial radial nerve and the SI cortex also converged upon this area.5. The organization of CF projections from trigeminal and superficial radial nerve afferents to the cerebellar hemisphere was found to occur in the same 'patchy' pattern of somatotopy that has been described for spinal nerve inputs to the anterior lobe.6. One constant factor was found in the pattern of organization of CF projections to this area from cutaneous afferent nerves. That is, only the afferents from overlapping areas of skin projected to a given recording point: no instance of CF projections from trigeminal branches innervating discontinuous skin areas was observed.

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Section: Pattern Of Projectionmentioning

confidence: 63%

“…4B, with the position of each track being indicated by an arrow. The convention used by other authors (Eccles et al 1968b) for illustration of the projection pattern to points in the cerebellum from several inputs has been adopted here. .…”

mentioning

confidence: 99%

Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

Miles¹,

Wiesendanger²

1975

The Journal of Physiology

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“…Comparison with earlier studies (e.g. Oscarsson, 1968;Eccles, Provini, Strata & Taborikova, 1968) indicates that such responses are typical of field potentials set up in the cortex by a volley in the climbing fibres that constitute the final stage of the SOCPs and further evidence supporting this identification is presented later. Figure 1B shows for comparison the pattern of response evoked at the same recording site from the ipsilateral SR nerve and in this case a sequence of two negative-positive diphasic potentials is evident.…”

Section: Resultsmentioning

confidence: 82%

“…Here it should be noted that microelectrodes were routinely positioned in depth so as to record the largest possible potentials and that the SOCP responses were sometimes initially negative as in Figs 1 and 2 and sometimes initially positive as in Oscarsson, 1968;Eccles et al 1968). In light of these findings responses evoked via SOCPs are treated below in a uniform manner irrespective of polarity.…”

Section: Resultsmentioning

confidence: 99%

“…The explanation of this reversal provided by Eccles et al (1968) is that the initial phase of the response represents an extracellular record of the very large excitatory postsynaptic potentials (EPSPs) evoked in the Purkinje cells by impulses in their climbing fibre afferents. Such EPSPs are seen as a large negativity when the microelectrode tip is in the deeper parts of the molecular layer, level with the climbing fibre-Purkinje cell synapses.…”

Section: Resultsmentioning

confidence: 99%

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Locomotion‐related variations in excitability of spino‐olivocerebellar paths to cat cerebellar cortical c2 zone.

Apps

Lidierth

Armstrong

1990

The Journal of Physiology

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SUMMARY1. Cutaneous nerve stimulation was used to study the excitability of the spinoolivocerebellar pathways (SOCPs) to the c2 zone of the paravermal cerebellar cortex in the cat. Non-noxious single-shock stimulation of the right and left superficial radial (SR) nerves via implanted cuff electrodes was used to evoke field potentials in the cerebellar cortex via the SOCPs.2. The evoked potentials were recorded extracellularly either in lobule V of the anterior lobe (three cats) or within the paramedian lobule of the posterior lobe (one cat) with glass-coated tungsten microelectrodes. Measurement of the amplitudes of the responses was used to monitor transmission in the SOCPs in cats at rest and during walking.3. A total of eleven c2 recording sites were investigated in detail. At seven of these sites, responses were recorded both during locomotion and at rest. For all seven sites responses during locomotion were smaller, more variable in amplitude and less securely evoked (average reduction 59%). 4. At five out of the eleven recording sites (45 %) the mean amplitude of responses elicited during different tenths of the step cycle fluctuated sufficiently that the largest response was more than twice the smallest. In the majority of these cases (4/5) the responses were largest in either mid-stance or late swing. These fluctuations in response size occurred without parallel fluctuation in the amplitude of the peripheral nerve volley. At the remaining sites fluctuation of the cerebellar field size was less and in some cases practically absent.5. At six recording sites it was possible to record the climbing fibre potentials evoked by stimulation of both the ipsilateral and contralateral superficial radial nerves. In all six cases the fluctuations in size of the response during locomotion occurred in phase, despite the fact that the two limbs move out of phase.6. The probability that an individual stimulus would evoke any cerebellar response also varied between the different tenths of the step cycle and such variations occurred in parallel with the fluctuations in response size. This shows that the SOCP regulatory mechanisms) must, at least in part, operate at a precerebellar level.MS 8015 R. APPS, M. LIDIERTH AND D. M. ARMSTRONG

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Organization of ascending pathways to the forelimb area of the dorsal accessory olive in the cat

1998

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The purpose of these experiments was to define the topography of cuneate and spinal projections to the forelimb representation in the rostral dorsal accessory olive (rDAO). We were interested in determining whether the spinal and cuneate inputs constitute a homogeneous afferent source, and whether there is evidence that they serve different functional roles. We were also interested in determining whether the somatotopy of rDAO is the result of a point-to-point projection from its afferent sources, or whether the projection suggests a reorganization of afferents at the olive. Single unit recording was used to identify specific regions of rDAO, and the topography of inputs to the identified regions was determined by using wheat germ agglutinin-horseradish peroxidase (WGA-HRP) as a tracer. The results from retrograde tracing were confirmed by using WGA-HRP as an anterograde tracer from input sources. The cuneate and spinal neurons providing input to rDAO constitute two distinct neural populations. One consists of cells in the caudal cuneate nucleus and lamina VI of the rostral two cervical segments, the other consists of cells in the rostral cuneate nucleus. The cells in the caudal cuneate nucleus and the rostral cervical segments are large, multipolar neurons that form a single column of rDAO input cells. The column of cells projects to the contralateral rDAO in a topographic fashion with rostral regions of the column projecting to rostral rDAO, which contains cells that respond to somatosensory stimulation of the contralateral shoulder, trunk, and proximal forelimb. Caudal regions of the column project to caudal rDAO, which contains cells that respond to stimulation of the distal forelimb. Despite this topography, there is a large degree of overlap in the terminations from neighboring regions of the input column, indicating that a major reorganization occurs at the rDAO. The projection from the rostral cuneate nucleus arises from small neurons that project bilaterally to rDAO, and the input from the rostral cuneate nucleus lacks a clear topography. We propose that input from the cell column is responsible for the somatosensory sensitivity of rDAO neurons, whereas input from rostral cuneate is most likely modulatory, probably inhibitory, in nature.

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Topographical investigations on the climbing fiber inputs from forelimb and hindlimb afferents to the cerebellar anterior lobe

Cited by 85 publications

References 25 publications

Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

Organization of climbing fibre projections to the cerebellar cortex from trigeminal cutaneous afferents and from the SI face area of the cerebral cortex in the cat.

Locomotion‐related variations in excitability of spino‐olivocerebellar paths to cat cerebellar cortical c2 zone.

Organization of ascending pathways to the forelimb area of the dorsal accessory olive in the cat

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