Topographical distribution of bronchial eosinophilia: significance for biopsy diagnosis

Abstract

Field-by-field (0.324 × 0.09 μM) counts of eosinophils were applied to the lamina propria of cartilaginous bronchi from 47 Los Angeles and 22 Miami residents 11 to 30 years of age who died suddenly from violence. A highly variable topographical distribution was found that appeared to be due mainly to variations in confluent eosinophil-positive fields and "hot spots" (≥3 eosinophils per field). Since biopsy is the gold standard for the diagnosis of bronchial eosinophilia, there is a need to resolve the problem of non-uniformity. New measurements applicable to biopsy diagnosis are presented having potential usefulness for providing insight into the severity and topographical distribution of eosinophilia within bronchi that are the sites of biopsy. The additional finding of a 30.4% incidence of moderate to marked eosinophilia (>1.5 eosinophils/mm reticular basement membrane) suggests a high level of asthma or asthmatic-like disease in the young subjects of this study.