Topographical control of human macrophages by a regularly microstructured polyvinylidene fluoride surface

Paul, N; Skazik, Claudia; Harwardt, Marc; Bartneck, Matthias; Denecke, Bernd; Klee, Doris; Salber, Jochen; Zwadlo-Klarwasser, Gabriele

doi:10.1016/j.biomaterials.2008.07.010

Cited by 114 publications

(104 citation statements)

References 28 publications

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“…It was reported that microstructured but not nanostructured PVDF triggered the activation of macrophages in a different way than LPS [18]. This may partially explain what was observed in the present study.…”

Section: Discussioncontrasting

confidence: 53%

Reduced immune cell responses on nano and submicron rough titanium

Webster

2015

Acta Biomaterialia

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Section: Discussioncontrasting

confidence: 53%

Reduced immune cell responses on nano and submicron rough titanium

Webster

2015

Acta Biomaterialia

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“…Recent studies indicated that the surface topographies of materials could considerably affect cellular behavior in the foreign body reaction. 29,50 Porous structures tend to result in a moderate tissue response, and fibrous capsule formation on a porous surface is found to be thinner than that on a dense solid implant surface.…”

mentioning

confidence: 99%

Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber

Luo¹,

He²,

Chang³

et al. 2016

IJN

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“…Microstructured topographical modification of polyvinylidene fluoride was shown to induce production of pro-and antiinflammatory factors by human primary macrophages [69]. Moderate effects of surface topography modifications on the production of TNF-a, MCP-1, MIP-1a, and vascular endothelial growth factor were detected in murine RAW 264.7 macrophages, cultured on poly(dimethylsiloxane) films [70].…”

Section: Macrophage Responses To Implantsmentioning

confidence: 99%

Macrophage responses to implants: prospects for personalized medicine

Kzhyshkowska

Gudima

Riabov

et al. 2015

Journal of Leukocyte Biology

168

137

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Implants, transplants, and implantable biomedical devices are mainstream solutions for a wide variety of human pathologies. One of the persistent problems around nondegradable metallic and polymeric implants is failure of macrophages to resolve the inflammation and their tendency to stay in a state, named "frustrated phagocytosis." During the initial phase, proinflammatory macrophages induce acute reactions to trauma and foreign materials, whereas tolerogenic antiinflammatory macrophages control resolution of inflammation and induce the subsequent healing stage. However, implanted materials can induce a mixed pro/ anti-inflammatory phenotype, supporting chronic inflammatory reactions accompanied by microbial contamination and resulting in implant failure. Several materials based on natural polymers for improved interaction with host tissue or surfaces that release antiinflammatory drugs/bioactive agents have been developed for implant coating to reduce implant rejection. However, no definitive, long-term solution to avoid adverse immune responses to the implanted materials is available to date. The prevention of implant-associated infections or chronic inflammation by manipulating the macrophage phenotype is a promising strategy to improve implant acceptance. The immunomodulatory properties of currently available implant coatings need to be improved to develop personalized therapeutic solutions. Human primary macrophages exposed to the implantable materials ex vivo can be used to predict the individual's reactions and allow selection of an optimal coating composition. Our review describes current understanding of the mechanisms of macrophage interactions with implantable materials and outlines the prospects for use of human primary macrophages for diagnostic and therapeutic approaches to personalized implant therapy. J. Leukoc. Biol. 98: 953-962;

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Topographical control of human macrophages by a regularly microstructured polyvinylidene fluoride surface

Cited by 114 publications

References 28 publications

Reduced immune cell responses on nano and submicron rough titanium

Reduced immune cell responses on nano and submicron rough titanium

Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber

Macrophage responses to implants: prospects for personalized medicine

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