Topographic sector‐by‐sector analysis of the optic nerve head by HRT and correlation with frank glaucoma perimetric indices

Rolle, Teresa; Salvini, S; Favero, Chiara; Borasio, Edmondo; Manea, Mirela; Brogliatti, B.; Grignolo, Federico

doi:10.1111/j.1600-0420.2000.tb01088.x

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to this morphology-driven assumption, molecular evidence has clarified for various types of eyes that a single transcription factor, Pax6, is present in all eyes regardless of their receptor cell type (rhabdomeric or ciliogenic) or developmental origin (ectodermal or neuroectodermal) (Arendt 2003; Vopalensky et al 2012; Rolle et al 2000). This suggests that all complex eyes derive from a common ancestor (Gehring 2011) that likely consisted of a pair of clonally related sensory/pigment cells through ‘division of labor’ (Arendt et al 2009).…”

Section: Turning Mechanosensory Cells Into Organs To Detect Specifmentioning

confidence: 99%

Evolution of vertebrate mechanosensory hair cells and inner ears: toward identifying stimuli that select mutation driven altered morphologies

2013

View full text Add to dashboard Cite

Among the major distance senses of vertebrates, the ear is unique in its complex morphological changes during evolution. Conceivably, these changes enable the ear to adapt toward sensing various physically well-characterized stimuli. This review develops a scenario that integrates sensory cell with organ evolution. We propose that molecular and cellular evolution of the vertebrate hair cells occurred prior to the formation of the vertebrate ear. We previously proposed that the genes driving hair cell differentiation, were aggregated in the otic region through developmental re-patterning that generated a unique vertebrate embryonic structure, the otic placode. In agreement with the presence of graviceptive receptors in many vertebrate outgroups, it is likely that the vertebrate ear originally functioned as a simple gravity-sensing organ. Based on the rare occurrence of angular acceleration receptors in vertebrate outgroups, we further propose that the canal system evolved with a more sophisticated ear morphogenesis. This evolving morphogenesis obviously turned the initial otocyst into a complex set of canals and recesses, harboring multiple sensory epithelia each adapted to the acquisition of a specific aspect of a given physical stimulus. As support for this evolutionary progression, we provide several details of the molecular basis of ear development.

show abstract

Section: Turning Mechanosensory Cells Into Organs To Detect Specifmentioning

confidence: 99%

Evolution of vertebrate mechanosensory hair cells and inner ears: toward identifying stimuli that select mutation driven altered morphologies

2013

View full text Add to dashboard Cite

show abstract

Efficacy and Safety of Memantine Treatment for Reduction of Changes Associated with Experimental Glaucoma in Monkey, II: Structural Measures

Hare

WoldeMussie

Weinreb

et al. 2004

Invest. Ophthalmol. Vis. Sci.

166

View full text Add to dashboard Cite

show abstract

Topographic sector‐by‐sector analysis of the optic nerve head by HRT and correlation with frank glaucoma perimetric indices

Cited by 2 publications

References 4 publications

Evolution of vertebrate mechanosensory hair cells and inner ears: toward identifying stimuli that select mutation driven altered morphologies

Evolution of vertebrate mechanosensory hair cells and inner ears: toward identifying stimuli that select mutation driven altered morphologies

Efficacy and Safety of Memantine Treatment for Reduction of Changes Associated with Experimental Glaucoma in Monkey, II: Structural Measures

Contact Info

Product

Resources

About