Topographic Macular Microvascular Changes and Correlation With Visual Loss in Chronic Leber Hereditary Optic Neuropathy

Borrelli, Enrico; Balasubramanian, Siva; Triolo, Giacinto; Barboni, Piero; Sadda, Srinivas R.; Sadun, Alfredo A.

doi:10.1016/j.ajo.2018.05.029

Cited by 50 publications

(52 citation statements)

References 48 publications

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“…Leber hereditary optic neuropathy (LHON) is a hereditary mitochondriopathy that causes painless vision loss, typically bilateral, that often affects young males. Its signs include transient telangiectasia seen in OCTA [ 55 – 57 ], swelling of the RNFL (pseudoedema) in OCT, and absence of leakage in FA [ 57 , 58 ]. In a OCTA study of 22 patients with LHON divided into four groups (unaffected carriers of the mitochondrial DNA mutation, symptomatic patients in the early subacute phase, late subacute, and chronic), a significant drop in RPC density (19.06%) was first observed in the temporal regions of early subacute patients compared with the unaffected carriers.…”

Section: Methodsmentioning

confidence: 99%

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Principles of OCTA and Applications in Clinical Neurology

Wylęgała

2018

Curr Neurol Neurosci Rep

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Purpose of ReviewThe article reviews the recent findings on the use of optical coherence tomography angiography (OCTA) in neurology.Recent FindingsOCTA is a new addition to the powerful and complementary technology of the OCT. Due to its noninvasiveness, and reproducibility, it is possible to obtain high-resolution 3D images of the vessels of the human eye. As the vessels of the retina with the presence of endothelial cell’s tight junctions resemble the brain vessels, it was hypothesized that the imaging of the retinal vessels might bring insight into brain vessels. OCTA has been effectively used to predict retinal vessel abnormalities in dementia, demyelization, optic disc neuropathies, and inherited degenerative diseases. Most common findings were decrease of vascular density and flow and an increase of avascular zones.SummaryAlthough OCTA is a relative new technology, recent studies show that it can be successfully applied in neurology.

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Section: Methodsmentioning

confidence: 99%

“…This study also observed higher decrease in the inferior and temporal regions of the disc where the papillomacular bundle is located. However, in contrary to decrease in SCP that correlates with decrease in visual loss, the authors observed no correlation between the visual loss and OCT structural damages [ 55 ].…”

Section: Methodsmentioning

confidence: 99%

Principles of OCTA and Applications in Clinical Neurology

Wylęgała

2018

Curr Neurol Neurosci Rep

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“…We decided to use three different binarization algorithms to assess differences/correlations between 3D and 2D OCTA metrics independently on the binarization threshold applied to the 2D OCTA images. The binarized SCP and DVC images were also skeletonized, in order to measure the vessel length density, which is based on an image in which vessels are visualized as tracings of 1 pixel in width, as previously described [11,18,39]. The 2D average perfusion density was calculated as the mean of SCP and DCP perfusion density values.…”

Section: D Octa Metricsmentioning

confidence: 99%

Quantification of diabetic macular ischemia using novel three‐dimensional optical coherence tomography angiography metrics

Borrelli

Sacconi

Querques

et al. 2020

Journal of Biophotonics

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We applied three-dimensional (3D) analysis to optical coherence tomography angiography (OCTA) to measure macular ischemia in eyes affected by non-proliferative diabetic retinopathy (DR). A previously validated algorithm was applied to OCTA data in order to obtain 3D visualization of the retinal vasculature. Successively, a global thresholding algorithm was applied and two novel quantitative metrics were introduced: 3D vascular volume and 3D perfusion density. Two-dimensional (2D) OCTA metrics were also obtained with different binarization thresholds for comparison. Of the 30 patients included, 15 were diagnosed with DR and 15 were controls. The 3D vascular volume and 3D perfusion density were reduced in DR eyes (P < .0001). The 2D variables also significantly differ between groups. The 3D perfusion density had the highest area under the receiver operating characteristic curve (0.964) among tested variables. Assessing quantitative perfusion using 3D analysis is reliable and promising, and with an elevated diagnostic efficacy in identifying DR eyes.

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“…• The perfusion density can be calculated as a unitless proportion of the number of pixels over the threshold divided by the total • The vessel diameter index, which represents the average vessel caliber, may be calculated by dividing the total vessel area in the binarized image by the total vessel length in the skeletonized image [23]. Fig.…”

Section: Octa Quantitative Metricsmentioning

confidence: 99%

Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

et al. 2019

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Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. Furthermore, this imaging modality has been widely adopted to investigate different ocular and systemic diseases. In this review, a discussion of the fundamental principles of OCTA is followed by the application of this imaging modality to study the retinal and choroidal vessels. A proper comprehension of this imaging modality is essential for the interpretation of OCTA imaging applications in retinal and choroidal disorders.

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Topographic Macular Microvascular Changes and Correlation With Visual Loss in Chronic Leber Hereditary Optic Neuropathy

Cited by 50 publications

References 48 publications

Principles of OCTA and Applications in Clinical Neurology

Principles of OCTA and Applications in Clinical Neurology

Quantification of diabetic macular ischemia using novel three‐dimensional optical coherence tomography angiography metrics

Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

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