Topographic Correlation Between Juxtapapillary Choroidal Thickness and Microstructure of Parapapillary Atrophy

Lee, Seung Hyen; Lee, Eun Ji

doi:10.1016/j.ophtha.2016.05.006

Cited by 32 publications

(36 citation statements)

References 43 publications

(46 reference statements)

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“…The mean JPCT was smaller in the eyes with only β-zone than in those having γ-zone, which is consistent with our previous report 4. However, the JPCT did not differ between the eyes with and without an MvD in the group with only β-zone.…”

Section: Discussionsupporting

confidence: 91%

“…It has been reported that the γ-zone is associated neither with the presence10 nor with the progression of glaucoma 19. Our previous study found that the γ-zone was not correlated with the reduction of JPCT, and so it was proposed that γ-zone is not associated with decreased perfusion 4. However, the findings of the present study suggest that localised perfusion impairment can exist near an MvD also in eyes with γ-zone.…”

Section: Discussioncontrasting

confidence: 80%

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Topographic correlation between juxtapapillary choroidal thickness and parapapillary deep-layer microvasculature dropout in primary open-angle glaucoma

Lee

Kim

2017

Br J Ophthalmol

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 80%

Topographic correlation between juxtapapillary choroidal thickness and parapapillary deep-layer microvasculature dropout in primary open-angle glaucoma

Lee

Kim

2017

Br J Ophthalmol

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“…In case of the termination of BM is not clearly visible on the horizontal EDI B-scan, we reviewed the radial B-scans from GMPE mode to identify the result of BMO delineation, and referred to them for determination of BM termination points on the EDI B-scans. The measurement was performed using a previously described method [6][7][8][9][10][11] .…”

mentioning

confidence: 99%

Parapapillary atrophy and changes in the optic nerve head and posterior pole in high myopia

Sung

Heo

Piao

et al. 2020

Sci Rep

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We investigated the relationship between microstructure of β-parapapillary atrophy (β-ppA) and morphologic features of optic nerve head (onH) and posterior pole in highly myopic eyes. eighty-nine highly myopic eyes were included in this study. Bruch's membrane opening (BMo) area, lamina cribrosa (Lc) thickness, anterior laminar depth, peripapillary and subfoveal choroidal thickness (ct), macular Bruch's membrane (BM) length, and width of β-ppA with and without Bruch's membrane (ppA +BM and ppA −BM ) were evaluated. The mean age and axial length of the included subjects were 26.88 ± 2.44 years and 27.03 ± 0.88 mm, respectively. The width of PPA −BM was larger with increasing BMo area (P = 0.001), whereas the BMO area was not associated with the width of PPA +BM . the large ppA +BM was significantly related to a thinner LC (P = 0.003), deeper anterior lamina surface (P < 0.001), longer macular BM length (P = 0.008), and thinner temporal peripapillary CT (P = 0.034). We found that the morphologic features of the ONH and posterior pole in highly myopic eyes were different based on the microstructure of β-ppA. Whether these features are linked to the development of glaucoma in myopic eyes should be investigated in future studies.Classic funduscopic β-parapapillary atrophy (β-PPA) is a region of visible large choroidal vessels and sclera due to the lack of retinal pigment epithelium (RPE). β-PPA can be histologically subclassified based on the presence or absence of Bruch's membrane (BM): β-PPA with BM (PPA +BM ; β zone) and β-PPA without BM (PPA −BM ; γ zone). It has been known that PPA +BM might be due to age-related atrophy of the RPE and associated with the development of glaucoma 1-4 . Whereas, PPA −BM has been considered as a result of mechanical stretching in the peripapillary sclera and border tissue during axial elongation; hence a significant association between axial length and PPA −BM width has been consistently reported 1-3,5 . However, we previously reported that PPA +BM was also found in 20-30-year-old myopia subjects and suggested that PPA +BM in young myopia patients might be related to axial elongation, not age-related atrophy 6 . In accordance with our report, Lee et al. 7 recently found an enlargement of PPA +BM as myopia progressed and proposed that PPA +BM found in children might be an entirely different entity from PPA +BM in elderly individuals, sharing an etiology with PPA −BM .Several factors might contribute to β-PPA development during axial elongation, but the etiology of PPA +BM and PPA −BM enlargement remains elusive so far. It is unclear why some myopia patients exhibit only PPA −BM , whereas others with a similar degree of myopia exhibit both PPA +BM and PPA −BM . In this study, we hypothesized that morphologic features of the optic nerve head (ONH) and the posterior pole might give clues to the mechanisms of differential developments of β-PPA in myopic eyes. Therefore, the purpose of this work was to investigate the relationship between microstructure of β-PPA and the morphologic featur...

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“…But previous investigations have also revealed that PPA +BM was more significantly correlated with glaucoma [1,2,4,43]. Teng et al [44] described that high IOP in patients with glaucoma may cause obstruction of the parapapillary choriocapillaris and, in turn, may lead to the degeneration of the RPE and adjacent cells.…”

Section: Discussionmentioning

confidence: 97%

“…On the basis of the location of Bruch's membrane (BM) termination, β-zone PPA can be classified into β-parapapillary atrophy with and without BM (PPA +BM and PPA -BM ). The region with BM but without the RPE is PPA +BM , and the region with neither the RPE nor BM is PPA -BM (or in other words γ-zone PPA) [1]. Several clinic-based studies have shown that PPA +BM was mostly associated with glaucoma, older age, and myopia.…”

Section: Introductionmentioning

confidence: 99%

Association of macular thickness with parapapillary atrophy in myopic eyes

Piao

Guo

et al. 2020

Preprint

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KEYWORDSmacular thickness, axial length, myopia, β-parapapillary atrophy with Bruch's membrane, β-parapapillary atrophy without Bruch's membrane Abstract Background: To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes. Methods:The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch's membrane (PPA +BM and PPA -BM , respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA. Results: An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA -BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA +BM width and macular intraretinal layer thickness. Moreover, both PPA +BM and PPA -BM widths significantly correlated with subfoveal choroidal thickness. Conclusions: Macular intraretinal layer thickness may be affected by PPA -BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.

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Topographic Correlation Between Juxtapapillary Choroidal Thickness and Microstructure of Parapapillary Atrophy

Cited by 32 publications

References 43 publications

Topographic correlation between juxtapapillary choroidal thickness and parapapillary deep-layer microvasculature dropout in primary open-angle glaucoma

Topographic correlation between juxtapapillary choroidal thickness and parapapillary deep-layer microvasculature dropout in primary open-angle glaucoma

Parapapillary atrophy and changes in the optic nerve head and posterior pole in high myopia

Association of macular thickness with parapapillary atrophy in myopic eyes

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