Topographic Aspects of EEG Profile of Some Psychotropic Drugs

Laurian, S.; Gaillard, Jean Michel; Le, P. K.; Schöpf, Josef

doi:10.1159/000408529

Cited by 11 publications

(6 citation statements)

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“…Brain mapping studies indicated that the increases in slow delta and theta waves occurred mainly in the fronto-temporal areas, the reduction in the alpha range in the occipital areas, and the increase in beta activity in the fronto-central regions [13][14][15]. Amitriptyline induced pronounced slowing of the EEG due to its more potent sedative properties.…”

Section: Eegmentioning

confidence: 99%

EEG profile of litoxetine after single and repeated administration in healthy volunteers.

Patat¹,

Trocherie²,

Thebault³

et al. 1994

Brit J Clinical Pharma

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1 Litoxetine is a selective serotonin reuptake inhibitor with antidepressant activity in animal models and in depressed patients. 2 This double-blind, cross-over, placebo-controlled study was carried out in 12 healthy young male volunteers. The aim was to assess the EEG profile of litoxetine in parallel with its pharmacokinetics after a single dose or multiple administrations for 4 days (6 doses) of two dosages (10 mg and 25 mg). Spectral analysis of four EEG leads (F4-T4, F3-T3, T4-02 and T3-01) was done up to 12 h post-dose. 3 In single or multiple doses, litoxetine induced EEG changes characterised by a doserelated increase in fast beta energies, mainly beta 2, without any changes in slow waves (delta and theta). A slight reduction in alpha activity occurred only after repeated doses. 4 EEG changes occurred after a single oral administration and lasted at least 12 h with litoxetine blood concentrations ranging from 4 to 10 ng ml-'. With repeated administrations, the pharmacodynamic steady-state was achieved as the increase in beta 2 energies was the same before and 12 h post-dose. These effects occurred with litoxetine blood concentrations ranging from 3 to 7 ng ml-1 with the 10 mg dosage and from 8 to 18 ng ml-1 with the 25 mg dosage. The EEG profile did not change after 4 days of repeated administration, indicating that tolerance did not develop. 5 Cmax and AUC showed proportionality between the administered dosages of 10 and 25 mg. Mean tmax ranged from 3 to 4 h and mean elimination half-life from 7 to 9 h independently of the dosage. Pharmacokinetic steady-state was achieved on day 4. Litoxetine did not accumulate with a twice daily regimen. 6 In conclusion, the EEG profile of litoxetine resembles those previously described with non-sedative antidepressants. Such EEG changes generally occur at therapeutic dosages.

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Section: Eegmentioning

confidence: 99%

EEG profile of litoxetine after single and repeated administration in healthy volunteers.

Patat¹,

Trocherie²,

Thebault³

et al. 1994

Brit J Clinical Pharma

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“…Reports by Kiinkel [11], Kiinkel et al [12] and more recent studies by Buchsbaum et al [13], Coppola and Herrmann [14], Itil and Itil [15], Laurian et al [16], Pockberger et al [17] and Sannita et al [18], make it clear that psychotropic-related EEG changes are far from homogeneous across brain regions. These studies under score the need for a comprehensive, multichannel topo graphic EEG approach in that single site recordings may well miss significant central effects and produce incom plete or misleading pharmaco-EEG profiles.…”

Section: Introductionmentioning

confidence: 99%

Brain Electrical Imaging the Dose-Response Effects of Cigarette Smoking

Knott

1989

Neuropsychobiology

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Quantitative regional electroencephalographic (EEG) effects of cigarette smoking were examined within a repeated measures design which assessed, and topographically displayed, changes in power spectral estimates resulting from the smoking of low, medium and high tar/nicotine (T/N) yield cigarettes. Although intercigarette yield comparisons revealed no significant EEG differences between yields, comparison of the effects of smoking each yield with sham smoking indicated the presence of a qualitative dose-response effect whereby increasing T/N yields resulted in a progressive posterior-to-anterior spreading of sigificant relative power changes within both theta and alpha frequency bands. These exploratory findings are discussed in relation to smoking maintenance and working hypotheses are formulated for future testing.

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“…He goes on to state that one will end up with incomplete or mis leading data if analysis is restricted to one channel [Kiinkel, 1982]. Recently several studies have reported topo graphic distinctions in psychotropic drug effects on EEG [Laurian et al, 1983;Sannita et al, 1983], Multichannel recording also allows the study of coherence in relation to pharmaco-EEG [Pockberger et al, 1984], The recent developments of topographic mapping of EEG make it clear that pharmaco-EEG studies should be extended in this direction [Coppola, 1982;Duffy, 1986;Etevenon et al, 1985]. Recording of multilead data also allows the generation of color-coded displays that are a succinct way of viewing both the topographic and quantitative structure of the EEG.…”

Section: Introductionmentioning

confidence: 99%

Psychotropic Drug Profiles: Comparisons by Topographic Maps of Absolute Power

Coppola

Herrmann

1987

Neuropsychobiology

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In a double-blind fourfold crossover design, 11 subjects were randomly assigned to placebo, 10 mg diazepam, 75 mg amitriptyline, and 75 mg chlorpromazine. During a simple vigilance task, 12 midline and left hemisphere leads were recorded before and 3 h after drug administration. The EEG was quantified by spectrum analysis, the topographic structure displayed by brain mapping techniques, and the results compared with earlier studies which used the same design and drugs. Diazepam showed the expected increase in beta; however, fast beta was increased as much as slow beta. Amitriptyline showed an increase of slow wave power and a reduction of alpha. In contrast to earlier studies, a decrease of fast beta was found. In addition, the spatial pattern of alpha changed from an occipital to a parietal maximum. Chlorpromazine showed an increase in the theta band. In occipital regions, there was a small decrease of fast beta; however, centrally there was an increase of both slow and fast beta. These results were confirmed by a multivariate analysis of variance.

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Topographic Aspects of EEG Profile of Some Psychotropic Drugs

Cited by 11 publications

References 0 publications

EEG profile of litoxetine after single and repeated administration in healthy volunteers.

EEG profile of litoxetine after single and repeated administration in healthy volunteers.

Brain Electrical Imaging the Dose-Response Effects of Cigarette Smoking

Psychotropic Drug Profiles: Comparisons by Topographic Maps of Absolute Power

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