Topographic and functional neuroanatomical study of GABAergic disinhibitory striatum–nigral inputs and inhibitory nigrocollicular pathways: Neural hodology recruiting the substantia nigra, pars reticulata, for the modulation of the neural activity in the inferior colliculus involved with panic-like emotions

Castellan-Baldan, Lissandra; Kawasaki, Mateus da Costa; Ribeiro, Sandro J.; Calvo, Fabrício; Corrêa, Vani Maria Alves; Coimbra, Norberto Cysne

doi:10.1016/j.jchemneu.2006.05.002

Cited by 70 publications

(62 citation statements)

References 80 publications

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“…Such neurons are normally inhibited by tonic GABAergic inputs, which arise from the substantia nigra pars reticulata (31,37). The substantia nigra pars reticulata itself receives inhibitory inputs from the striatum that in turn receives inputs from the deep layers of the SC relayed via the thalamus as well as from the cortex and amygdala (31,69,105) (Fig.…”

Section: Role Of Midbrain Colliculi In Integrating Stress-evoked Respmentioning

confidence: 99%

Central mechanisms regulating coordinated cardiovascular and respiratory function during stress and arousal

Dampney

2015

American Journal of Physiology-Regulatory, Integrative and Comp

125

113

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Actual or potentially threatening stimuli in the external environment (i.e., psychological stressors) trigger highly coordinated defensive behavioral responses that are accompanied by appropriate autonomic and respiratory changes. As discussed in this review, several brain regions and pathways have major roles in subserving the cardiovascular and respiratory responses to threatening stimuli, which may vary from relatively mild acute arousing stimuli to more prolonged life-threatening stimuli. One key region is the dorsomedial hypothalamus, which receives inputs from the cortex, amygdala, and other forebrain regions and which is critical for generating autonomic, respiratory, and neuroendocrine responses to psychological stressors. Recent studies suggest that the dorsomedial hypothalamus also receives an input from the dorsolateral column in the midbrain periaqueductal gray, which is another key region involved in the integration of stress-evoked cardiorespiratory responses. In addition, it has recently been shown that neurons in the midbrain colliculi can generate highly synchronized autonomic, respiratory, and somatomotor responses to visual, auditory, and somatosensory inputs. These collicular neurons may be part of a subcortical defense system that also includes the basal ganglia and which is well adapted to responding to threats that require an immediate stereotyped response that does not involve the cortex. The basal ganglia/colliculi system is phylogenetically ancient. In contrast, the defense system that includes the dorsomedial hypothalamus and cortex evolved at a later time, and appears to be better adapted to generating appropriate responses to more sustained threatening stimuli that involve cognitive appraisal. defensive behavior; sympathetic activity; respiratory activity; hypothalamus; midbrain; sympathetic premotor nuclei AN ANIMAL'S SURVIVAL is dependent on being able to respond appropriately to stressors, which can be categorized into two different groups: interoceptive (also-called physical) stressors and exteroceptive (also-called psychological) stressors (44,133). Physical stressors are those that directly threaten homeostasis, such as hypoxia, hemorrhage, or infection, whereas psychological stressors can be defined as actual or perceived threats in the external environment. Psychological stressors can be further subdivided into conditioned stressors (i.e., ones that are normally innocuous but which are perceived as threatening because of previous experiences) or unconditioned stressors (i.e., ones that are intrinsically threatening, such as the sight, sound, or odor of a predator). Physical and psychological stressors activate different populations of neurons in the brain (44,63,102). Similarly, there is evidence that the autonomic responses to conditioned and unconditioned psychological stressors are also mediated by different pathways in the brain (62). In this review, which is based on my 2013 Carl Ludwig Distinguished Lecture to the American Physiological Society, I consider the brain mec...

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Section: Role Of Midbrain Colliculi In Integrating Stress-evoked Respmentioning

confidence: 99%

Central mechanisms regulating coordinated cardiovascular and respiratory function during stress and arousal

Dampney

2015

American Journal of Physiology-Regulatory, Integrative and Comp

125

113

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“…A utilização do registro dos potenciais evocados auditivos permitiu estudar a natureza das alterações eletrofisiológicas promovidas por drogas GABAérgicas injetadas tanto diretamente no CI quanto na SCPd, enquanto que a estimulação elétrica pôde fornecer alguns dados de como ocorre a expressão e o processamento de informações aversivas que passam por essas estruturas. Dados prévios sugerem que o CI seja regulado por filtros localizados na amígdala (Maisonnette et al, 1996;Macedo et al, 2005) e na substância negra (Castellan-Baldan et al, 2006). Nossos resultados sugerem que não só estas estruturas possam ser filtros para o CI, mas também a SCPd.…”

Section: Discussionunclassified

“…Isto se baseia em evidências de que o aumento gradual da estimulação elétrica no núcleo central do CI (CIC) elicia um comportamento de defesa progressivamente mais intenso, caracterizado por estados de alerta, congelamento e fuga, seguidos por respostas autonômicas similares àquelas causadas pelo medo eliciado diante de situações ameaçadoras (Melo & Brandão, 1995). Estima-se que, no CI, os potenciais de ação possam reverberar, aumentando a intensidade e duração da resposta induzida pelo estímulo auditivo aversivo (Castellan-Baldan et al, 2006). Adicionalmente, a estimulação química com NMDA nas porções ventral (vCI) ou dorsal (dCI) do colículo inferior induz diferentes níveis de expressão de Fos em outras estruturas cerebrais.…”

Section: Substrato Neural Dos Comportamentos Defensivosunclassified

“…(Maisonnette et al, 1998). In contrast, GABAergic neurons from the substantia nigra pars reticulata project to the IC and may modulate motor activity engendered at this level (Castellan-Baldan et al, 2006).…”

mentioning

confidence: 99%

“…Thus, in addition to the main loop configuration of the connections with most regions of the cerebral cortex, limbic system, and thalamus, a subcortical loop that consists of the basal ganglia and IC also exists. Projections from basal ganglia output areas (e.g., substantia nigra pars reticulata) back to the IC have also been reported (Castellan-Baldan et al, 2006). The functional significance of these connections has not yet been envisaged.…”

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confidence: 99%

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Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

Saito¹

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Neuroanatomical and neuropharmacological approaches to postictal antinociception‐related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors

Freitas¹,

Bolognesi

Twardowschy

et al. 2013

Brain and Behavior

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Several studies have suggested the involvement of the hippocampus in the elaboration of epilepsy. There is evidence that suggests the hippocampus plays an important role in the affective and motivational components of nociceptive perception. However, the exact nature of this involvement remains unclear. Therefore, the aim of this study was to determine the role of muscarinic and nicotinic cholinergic receptors in the dorsal hippocampus (dH) in the organization of postictal analgesia. In a neuroanatomical study, afferent connections were found from the somatosensory cortex, the medial septal area, the lateral septal area, the diagonal band of Broca, and the dentate gyrus to the dH; all these areas have been suggested to modulate convulsive activity. Outputs to the dH were also identified from the linear raphe nucleus, the median raphe nucleus (MdRN), the dorsal raphe nucleus, and the locus coeruleus. All these structures comprise the endogenous pain modulatory system and may be involved either in postictal pronociception or antinociception that is commonly reported by epileptic patients. dH-pretreatment with cobalt chloride (1.0 mmol/L CoCl2/0.2 μL) to transiently inhibit local synapses decreased postictal analgesia 10 min after the end of seizures. Pretreatment of the dH with either atropine or mecamylamine (1.0 μg/0.2 μL) attenuated the postictal antinociception 30 min after seizures, while the higher dose (5.0 μg/0.2 μL) decreased postictal analgesia immediately after the end of seizures. These findings suggest that the dH exerts a critical role in the organization of postictal analgesia and that muscarinic and nicotinic cholinergic receptor-mediated mechanisms in the dH are involved in the elaboration of antinociceptive processes induced by generalized tonic-clonic seizures.

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Cited by 70 publications

References 80 publications

Central mechanisms regulating coordinated cardiovascular and respiratory function during stress and arousal

Central mechanisms regulating coordinated cardiovascular and respiratory function during stress and arousal

Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

Neuroanatomical and neuropharmacological approaches to postictal antinociception‐related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors

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