TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53

Joo, Narae; Park, Sang-Ah; Park, Jung-Hwan; Oh, Sang‐Muk

doi:10.1016/j.bbrc.2023.04.113

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…Interferons exert an anticancer function; for instance, IFNα induces tumor cell death via the Fas pathway and is successfully used as a tumor immunotherapy ( Kimura et al, 2003 ). In general, tumor necrosis factors (TNFs) suppress P53 function and facilitate cell apoptosis ( Joo et al, 2023 ). In addition, colony-stimulating proteins, such as CSF-1 and their receptors, increase tumor cell proliferation and survival in an autocrine or paracrine manner ( Achkova & Maher, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of cytokine-induced cell communications by pan-cancer meta-analysis

Liu,

Zhao,

2023

PeerJ

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Cancer immune responses are complex cellular processes in which cytokine–receptor interactions play central roles in cancer development and response to therapy; dysregulated cytokine–receptor communication may lead to pathological processes, including cancer, autoimmune diseases, and cytokine storm; however, our knowledge regarding cytokine-mediated cell–cell communication (CCI) in different cancers remains limited. The present study presents a single-cell and pan-cancer-level transcriptomics integration of 41,900 cells across 25 cancer types. We developed a single-cell method to actively express 62 cytokine–receptor pairs to reveal stable cytokine-mediated cell communications involving 84 cytokines and receptors. The correlation between the sample-based CCI profile and the interactome analysis indicates multiple cytokine–receptor modules including TGFB1, IL16ST, IL15, and the PDGF family. Some isolated cytokine interactions, such as FN1–IL17RC, displayed diverse functions within over ten single-cell transcriptomics datasets. Further functional enrichment analysis revealed that the constructed cytokine–receptor interaction map is associated with the positive regulation of multiple immune response pathways. Using public TCGA pan-cancer mutational data, co-mutational analysis of the cytokines and receptors provided significant co-occurrence features, implying the existence of cooperative mechanisms. Analysis of 10,967 samples from 32 TCGA cancer types revealed that the 84 cytokine and receptor genes are significantly associated with clinical survival time. Interestingly, the tumor samples with mutations in any of the 84 cytokines and receptors have a substantially higher mutational burden, offering insights into antitumor immune regulation and response. Clinical cancer stage information revealed that tumor samples with mutations in any of the 84 cytokines and receptors stratify into earlier tumor stages, with unique cellular compositions and clinical outcomes. This study provides a comprehensive cytokine–receptor atlas of the cellular architecture in multiple cancers at the single-cell level.

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Section: Introductionmentioning

confidence: 99%

Identification of cytokine-induced cell communications by pan-cancer meta-analysis

Liu,

Zhao,

2023

PeerJ

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“…The DLX1, P53, and β-catenin are the key factors in cell apoptosis pathways, and overexpressions of DLX1, NF-κB, and β-catenin inhibit cell apoptosis and promote cell proliferation [8] . TNF-α and P53 promote cell apoptosis and inhibit cell proliferation [9] . Our results showed that DLX1, NF-κB, and β-catenin in the TUG1-OE group were significantly higher than those in the control group, and TNF-α and P53 expressions were significantly lower than those in the control group ( P <0.01).…”

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confidence: 99%

Long noncoding RNA TUG1 promotes proliferation, migration and cisplatin resistance in oral squamous cell carcinoma

Wang¹,

Yanshu²,

Xiao³

et al. 2023

ABBS

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Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes

Dhiman,

Mannan,

Taneja

et al. 2024

Life Sciences

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TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53

Cited by 5 publications

References 31 publications

Identification of cytokine-induced cell communications by pan-cancer meta-analysis

Identification of cytokine-induced cell communications by pan-cancer meta-analysis

Long noncoding RNA TUG1 promotes proliferation, migration and cisplatin resistance in oral squamous cell carcinoma

Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes

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