2013
DOI: 10.1016/j.brainres.2012.11.039
|View full text |Cite
|
Sign up to set email alerts
|

Topiramate reduces blood–brain barrier disruption and inhibits seizure activity in hyperthermia-induced seizures in rats with cortical dysplasia

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
15
0

Year Published

2014
2014
2024
2024

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 16 publications
(17 citation statements)
references
References 59 publications
2
15
0
Order By: Relevance
“…In fact, abnormal microvessels in brain parenchyma and focal BBB leakage were reported in rats with cortical dysplasia . Although there is no confirmation supported with human studies, it has been shown that both hyperthermic and kindled seizures increased BBB permeability to certain tracers including Evans blue, horseradish peroxidase, and sodium fluorescein in a rat model of cortical dysplasia . In the genetic absence epilepsy model of WAG/Rij rats, Sahin et al.…”
Section: What We Can Learn From Animal Studiesmentioning
confidence: 99%
See 1 more Smart Citation
“…In fact, abnormal microvessels in brain parenchyma and focal BBB leakage were reported in rats with cortical dysplasia . Although there is no confirmation supported with human studies, it has been shown that both hyperthermic and kindled seizures increased BBB permeability to certain tracers including Evans blue, horseradish peroxidase, and sodium fluorescein in a rat model of cortical dysplasia . In the genetic absence epilepsy model of WAG/Rij rats, Sahin et al.…”
Section: What We Can Learn From Animal Studiesmentioning
confidence: 99%
“…In their unpublished data, they observed a massive cortical tissue loss in WAG/Rij rats with cortical dysplasia, and suggested that the mechanism responsible for enhanced BBB permeability was increased caveolar vesicle–mediated transcellular transport. It has been suggested that enhancement of a transcellular pathway rather than paracellular opening of tight junctions accounts for the increase in BBB permeability in epileptic conditions as evidenced by ultrastructural observations . Given these many converging studies, a disrupted BBB, such as enhancement on imaging studies, could be a biomarker for the detection of epileptogenesis and translatable from animal studies to humans …”
Section: What We Can Learn From Animal Studiesmentioning
confidence: 99%
“…A third group of proteins involved in tight junction formation is made up by junction adhesion molecules which also contain intra-and extracellular domains [28][29][30]. Decreased expression of several tight junction proteins occurs in brain tissue of patients with epilepsy as well as in epileptic animals and is associated with increased BBB permeability [31][32][33][34][35][36].…”
Section: Blood-brain Barrier -Morphology and Transport Mechanismsmentioning
confidence: 99%
“…Notably, unless very high intensities or doses of respective stimuli are used, spontaneous seizures are not widespread. Instead, increased susceptibility to either experimentally-induced febrile seizures or pilocarpine administration is often observed (Battaglia et al, 2009;Cid et al, 2014;Fan et al, 2008;Gibbs et al, 2011;G€ urses et al, 2013;Setkowicz et al, 2003).…”
Section: Modeling Seizure Susceptibility and The "Second Hit Hypothesis"mentioning
confidence: 99%