Topiramate reduced sweat secretion and aquaporin-5 expression in sweat glands of mice

Ma, Lei; Huang, Yuan-Gui; Deng, Yanchun; Jiyu, Tian; Rao, Zhi-Ren; Che, Hao; Hf, Zhang; Zhao, Gang

doi:10.1016/j.lfs.2007.04.018

Cited by 29 publications

(21 citation statements)

References 37 publications

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“…Endoscopic thoracic sympathectomy is the main method of a radical cure for PFH; however, its side effects like compensatory hyperhidrosis, bradycardia and Horner's syndrome are impossible to be avoided completely [23]. Ma et al [24] reported that topiramate could reduce sweat secretion along with a decreased AQP5 expression by sweat glands in mice, suggesting that AQP5 may be involved in topiramate-induced hypohidrosis. So our study raises the possibility that the specific inhibition of AQP5 may provide a new nonsurgical treatment for PFH patients without the side effect and may avoid the damages of endoscopic thoracic sympathectomy.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of AQP5 Was Detected in Axillary Sweat Glands of Primary Focal Hyperhidrosis Patients

Lin²,

Yang³

et al. 2016

Dermatology

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Background: The expression of aquaporin 5 (AQP5) in human axillary sweat glands has never been studied so far. Objective: To detect the expression of AQP5 in axillary sweat glands of patients with primary focal hyperhidrosis (PFH) relative to control subjects. Methods: The morphological characteristics and the number of sweat coils in axillary sweat glands were compared between two groups by using transmission electron microscopy. The expression of AQP5 was detected by immunohistochemistry, Western blot analysis, and real-time transcription polymerase chain reaction. Results: There were no significant differences between the two groups in terms of morphological characteristics and the number of sweat coils in axillary sweat glands. The expressions of AQP5 protein and AQP5 mRNA were significantly higher in the patient group than in the control group. Conclusion: AQP5 is involved in the secretion of human axillary sweat glands. The overexpression of AQP5 in sweat glands is probably one pathogenetic mechanism underlying PFH.

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Section: Discussionmentioning

confidence: 99%

Overexpression of AQP5 Was Detected in Axillary Sweat Glands of Primary Focal Hyperhidrosis Patients

Lin²,

Yang³

et al. 2016

Dermatology

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“…It is shown that AQP5 is directly involved in sweat secretion and AQP3 is found in human keratinocytes [11]. Ma et al [12] demonstrated decreased sweat secretion and AQP5 expression by sweat glands of mice, proposing a role for AQP in hypohydrosis. Kabashima et al [13] reported aberrant expression of aquaporin 5 in the palmar sweat glands of a patient with APW and suggested that aquaporins may play a role in APW.…”

Section: Discussionmentioning

confidence: 99%

Aquagenic Palmar Wrinkling Induced by Combined Use of Salazopyrin and Indomethacin

Gündüz¹,

Özsaraç²,

Erçin

2013

Case Rep Dermatol

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Aquagenic palmar wrinkling (APW) is an uncommon dermatological condition, which manifests as asymptomatic or tender palmar papules and may cause discomfort and manual functional limitations during its flares. Despite some studies implying a relationship between cystic fibrosis (CF) and APW, there are also reports of APW cases without an accompanying CF. In this report we describe a 19-year-old ankylosing spondylitis patient, who developed APW lesions after the start of combined salazopyrin and indomethacin treatment. His palmar lesions were resistant to topical corticosteroid and aluminium hydroxide therapy and disappeared only after stopping the anti-inflammatory drugs. With this report, we aim to highlight and address this underrecognized dermatological condition and possible role of aquaporins in its pathogenesis.

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“…Ma et al [10] observed that topiramate reduced sweat secretion along with decreased aquaporin-5 expression by sweat glands in mice. Kabashima et al [6] reported the excessive aquaporin-5 expression in sweat glands during AWP.…”

Section: Discussionmentioning

confidence: 99%

Free Flow of Sweat due to Loss of Surface Tension at Sweat Droplet Causes Water-Induced Skin Wrinkling

Marasakatla¹,

Marasakatla²

2013

Preprint

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Water immersion skin wrinkling appears to be the result of breaking the balance between secretory pressure of sweat glands and the pressure exerted by the surface tension of sweat droplet at the pore. When a hand is immersed in water, sweat droplet easily merge within the water causing pressure to drop at the pore. The resulted imbalance in pressure enables the sweat to flow freely into the water. Flow of sweat continues as long as there is a blood flow to hand. To prevent the loss of sweat from the body and to maintain homeostasis, sympathetic nerves trigger the reduction of blood flow to hand causing vasoconstriction. The overlying skin wrinkles due to loss of volume under the skin.

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Topiramate reduced sweat secretion and aquaporin-5 expression in sweat glands of mice

Cited by 29 publications

References 37 publications

Overexpression of AQP5 Was Detected in Axillary Sweat Glands of Primary Focal Hyperhidrosis Patients

Overexpression of AQP5 Was Detected in Axillary Sweat Glands of Primary Focal Hyperhidrosis Patients

Aquagenic Palmar Wrinkling Induced by Combined Use of Salazopyrin and Indomethacin

Free Flow of Sweat due to Loss of Surface Tension at Sweat Droplet Causes Water-Induced Skin Wrinkling

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