Topiramate-induced macular neurosensory retinal detachment

Abstract

PurposeTo present a previously unreported retinal side-effect from topiramate use in two cases.ObservationsMacular neurosensory retinal detachments were seen in two patients shortly after beginning oral topiramate. The macular detachments resolved shortly after discontinuing this medication.Conclusions and importanceAs these two cases represent the first reports of topiramate-induced macular neurosensory retinal detachment, clinicians should be aware of this potential ocular side effect when administering this medication.

Acquired myopia followed by acquired hyperopia due to serous neurosensory retinal detachment following topiramate intake

“…In our case, neurosensory retinal detachment may be related to topiramate as there was diffuse choroidal thickening (including post pole) as well as earlier reports of the same, 7 though our fluorescein angiographic features were different from those reported in the literature. The angiographic and optical coherence tomographic features were typical of CSCR, which may have been induced by topiramate.…”

“…The subfoveal fluid resolved on the discontinuation of topiramate. This lady had received neither steroids nor laser peripheral iridotomy, 7 possibly denoting a causative association of topiramate with the subfoveal fluid.…”

“…However, the association seems to be not substantiated 6 as one of the cases had lattice, and the RRDs most likely happened secondary to posterior vitreous detachment which may not be related to topiramate use. Recently Rosenberg et al 7 presented two patients who developed neurosensory retinal detachment which resolved after discontinuation of topiramate. The first case, 7 a 29-year-old female, had choroidal detachment, serous retinal detachment, and peripheral intraretinal hemorrhages likely related to anemia and thrombocytopenia.…”

“…Recently Rosenberg et al 7 presented two patients who developed neurosensory retinal detachment which resolved after discontinuation of topiramate. The first case, 7 a 29-year-old female, had choroidal detachment, serous retinal detachment, and peripheral intraretinal hemorrhages likely related to anemia and thrombocytopenia. The second patient, 7 a 38-year-old female, had a unilateral neurosensory retinal detachment in the left eye.…”

“…The first case, 7 a 29-year-old female, had choroidal detachment, serous retinal detachment, and peripheral intraretinal hemorrhages likely related to anemia and thrombocytopenia. The second patient, 7 a 38-year-old female, had a unilateral neurosensory retinal detachment in the left eye. FA showed a window defect and no active leak.…”