Topiramate-induced Bilateral Anterior Uveitis Associated with Hypopyon Formation

Bonyadi, Mohammad Reza; Soheilian, Roham; Soheilian, Masoud

doi:10.3109/09273948.2010.523805

Cited by 23 publications

(17 citation statements)

References 7 publications

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“…In the literature, this is supported by: (a) a case of anterior uveitis and another case of vitritis associated with TiACG,56,89 and (b) three cases of refractory TiACG that responded dramatically to high doses of intravenous methylprednisolone 54,77,92…”

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 86%

“…32 On the other hand, TiACG can be refractory to ordinary ocular hypotensive drugs (whether topical or systemic), leading to ocular complications such as cataract, uveitis, and even permanent visual loss 61,89. The origin of the term “ciliochoroidal effusion syndrome” emerged in 2002 when ophthalmologists were trying to explain the pathomechanism of TiMS and TiACG 97.…”

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 99%

“…This imaging technique can provide a detailed evaluation of angle parameters and detect evidence of ciliochoroidal effusion 26,40,41,53–56,68,81,84. B-scan ultrasonography helps to detect posterior choroidal detachment which is usually shallow,34,42,46,51–54,66,69,89 but may sometimes be large and extend to the posterior pole 92…”

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 99%

“…Jabbarpoor Bonyadi et al89 reported a 40-year-old female with TiMS and TiACG who developed bilateral anterior uveitis and hypopyon after the control of a glaucoma attack. Systemic examination for other causes had negative results.…”

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 99%

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Topiramate and the vision: a systematic review

Abtahi¹,

Abtahi²,

Fazel³

et al. 2012

OPTH

106

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Background and purposeTopiramate (TPM) is a sulfa-derivative monosaccharide that is used mainly for treating epilepsy and preventing migraine. Within the gamut of side effects attributable to this drug, ophthalmologic manifestations are of crucial importance. In this study, for the first time, the aim was to provide a systematic literature review regarding this issue.MethodsFor the time period 1996–2011, a PubMed search was made for the studies concerning the adverse/beneficial effects of TPM on vision. Overall, 404 citations out of a total of 2756 TPM-related studies were examined for relevance.ResultsA total of 74 relevant studies were reviewed, 65 of which comprise small observational studies describing the ophthalmic side effects of TPM in 84 patients. Of these patients, 66 were affected by ciliochoroidal effusion syndrome as the cardinal ocular side effect of TPM (17 cases of myopic shift and 49 cases of angle closure glaucoma). A comprehensive statistical analysis is provided on these 66 subjects. Other rare side effects of TPM on the vision were also reviewed, including massive choroidal effusion, ocular inflammatory reactions, visual field defects, probable effects on retina, cornea, and sclera, and neuroophthalmologic complications. In addition, a framework is provided to classify these results.DiscussionDue to the expanding spectrum of indications for the administration of TPM, neurologists and psychiatrists should be aware of its diverse ocular side effects. In conclusion, ocular complications following this drug should be taken seriously and be subjected to ophthalmic counseling.

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Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 86%

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 99%

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 99%

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 99%

See 2 more Smart Citations

Topiramate and the vision: a systematic review

Abtahi¹,

Abtahi²,

Fazel³

et al. 2012

OPTH

106

View full text Add to dashboard Cite

show abstract

“…Since 2001, a range of adverse ocular effects associated with topiramate therapy have been described related to acute glaucoma and acute myopia. 2 More recently, the effects of topiramate on macula function have been reported. Topiramate-induced anterior uveitis has also been described in association with hypopyon formation.…”

Section: Introductionmentioning

confidence: 99%

Topiramate-induced maculopathy in IgG4-related disease

DaCosta

Younis

2016

DHPS

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This report describes a case of reversible topiramate-induced maculopathy in a 32-year-old female patient with IgG4-related disease. The patient presented with decreased vision associated with anterior uveitis and cystoid macula edema, which was unresponsive to oral and topical steroids. Following topiramate cessation, both cystoid macula edema and vision improved. The ocular side effects of topiramate and putative pharmacological mechanisms for topiramate-induced maculopathy in the context of IgG4-related disease are discussed. This report highlights that neurologists and ophthalmologists should be aware that patients presenting with topiramate-associated maculopathy should be advised to discontinue topiramate promptly to prevent irreversible loss of vision.

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Medication Induced

Papaliodis¹

2017

Uveitis

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Topiramate-induced Bilateral Anterior Uveitis Associated with Hypopyon Formation

Abstract: Topiramate should be added to the list of drugs that may cause anterior uveitis and hypopyon formation.

Cited by 23 publications

References 7 publications

Topiramate and the vision: a systematic review

Topiramate and the vision: a systematic review

Topiramate-induced maculopathy in IgG4-related disease

Medication Induced

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