Topiramate: efficacy and tolerability in children according to epilepsy syndromes

Mikaeloff, Yann; Saint‐Martin, Anne de; Mancini, J.; Peudenier, Sylviane; Pedespan, Jean-Michel; Vallée, Louis; Motté, Jacques; Bourgeois, Marie; Arzimanoglou, Alexis; Dulac, Olivier; Chiron, Catherine

doi:10.1016/s0920-1211(03)00028-7

Cited by 78 publications

(64 citation statements)

References 30 publications

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“…No acute or long-term idiosyncratic organ toxicity was observed with topiramate, which is consistent with the safety profile in earlier studies. 11,16,19,21,22 In addition, metabolic acidosis may occur, 21,23,24 and approximately 1.5% of patients treated with topiramate develop kidney stones in adult 25 and patients with metabolic acidosis, but they have not been registered in our study according to the observation of legal caregivers and the long-time follow up. The results were similar to those of the study by Ritter et al 26 In newly diagnosed patients with infantile spasms in our study, the parents were often not patient enough to wait for topiramate escalation to reach the target dose.…”

Section: Discussionmentioning

confidence: 85%

Prospective Study of First-choice Topiramate Therapy in Newly Diagnosed Infantile Spasms

Zou

Ding²,

Fang³

et al. 2006

Clinical Neuropharmacology

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Section: Discussionmentioning

confidence: 85%

Prospective Study of First-choice Topiramate Therapy in Newly Diagnosed Infantile Spasms

Zou

Ding²,

Fang³

et al. 2006

Clinical Neuropharmacology

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“…Indication: Topiramate is a highly efficacious adjunct in refractory focal or generalized epilepsy and peculiarly difficultto-treat epileptic encephalopathies, such as West syndrome and Lennox-Gastaut syndrome (LGS) [11,12].…”

Section: Topiramatementioning

confidence: 99%

Untitled

2017

Cent Asian J Med Sci

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Objectives: Up to one third of epilepsy patients have an unsatisfactory treatment with antiepileptic drugs (AEDs), but advance in neuroimaging, neurophysiologic investigation and treatment modalities have substantially improved the approaches and understanding of intractable childhood epilepsy. Methods: Journal papers, reports, books and government publications on epilepsy treatment were collected and reviewed in chronological order. Results:There are approximately more than 15 newer AEDs developed since 1990, highlighted by the novel mechanism of action with minimal adverse effect, thus they have been frequently used for those who are unresponsive to conventional AEDs. Non-pharmacologic therapies including diet therapy, epilepsy surgery, and neuromodulatory treatment are also effective and should be considered early in the disease course. Diet therapy began to reemerge in mid 1990s, and studies with large data collection allowed to overcome major concerns; its side effects, difficult compliance and doubts on efficacy. And more liberal forms of the diet therapy were introduced to benefit adults and patients in developing counties, where strict supervision is unavailable. The surgical treatment has become increasingly more valuable and it is now accepted for the management of drug resistant focal epilepsy due to major advances in presurgical investigation methods, and surgical techniques. Conclusions: The timely assessment of children with drugresistant epilepsy and active application of advanced treatment modalities were necessary to prevent the effect of uncontrolled seizures on cognitive and behavioral development.

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“…[230][231][232][233][234][235][236][237][238][239][240][241][242][243][244][245][246][247] Psychomotor slowing and distal extremity paraesthesias are less common in children than in adults. [236,237,242,245] In addition to the above specific cognitive problems, generalized cognitive dysfunction is reported in 4-31% of children and adults. [235,[248][249][250] Cognitive dulling, the most limiting adverse effect, may be reduced with slower titration, monotherapy use or reduction of concomitant AEDs.…”

Section: Cnsmentioning

confidence: 99%

The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents

Sarco

Bourgeois

2010

CNS Drugs

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The newer antiepileptic drugs (AEDs) provide more therapeutic options and overall improved safety and tolerability for patients. To provide the best care, physicians must be familiar with the latest tolerability and safety data. This is particularly true in children, given there are relatively fewer studies examining the effects of AEDs in children compared with adults. Since we now have significant paediatric literature on each of these agents, we provide a comprehensive and current literature review of the newer AEDs, focusing on safety and tolerability data in children and adolescents. Because the safety profiles in children differ from those in adults, familiarity with this literature is important for child neurologists and other paediatric caregivers. We have organized the data by organ system for each AED for easier reference.

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Topiramate: efficacy and tolerability in children according to epilepsy syndromes

Cited by 78 publications

References 30 publications

Prospective Study of First-choice Topiramate Therapy in Newly Diagnosed Infantile Spasms

Prospective Study of First-choice Topiramate Therapy in Newly Diagnosed Infantile Spasms

Untitled

The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents

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