Topiramate-chitosan nanoparticles prevent morphine reinstatement with no memory impairment: Dopaminergic and glutamatergic molecular aspects in rats

Milanesi, Laura Hautrive; Rossato, Domênika Rubert; Rosa, Jéssica Leandra Oliveira da; D’avila, Lívia Ferraz; Metz, Vinícia Garzella; Wolf, J.; Reis, Vanessa B.; Andrade, Diego Fontana de; Jank, Louíse; Beck, Ruy Carlos Ruver; Silva, Cristiane de B. da; Bürger, Marilise Escobar

doi:10.1016/j.neuint.2021.105157

Cited by 4 publications

(4 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, other studies found that morphine acts primarily on mesolimbic DA neurons such as nucleus accumbens (NAc) and ventral tegmental area 47,48 . Increased DAT immunoreactivity was also detected in the dorsal hippocampus in morphine‐CPP rats 45 . Combined with our findings, we consider that DAT function in the mesolimbic area plays a more important role on morphine‐induced craving and memory retrieval than that in the striatum.…”

Section: Discussionsupporting

confidence: 84%

“…47,48 Increased DAT immunoreactivity was also detected in the dorsal hippocampus in morphine-CPP rats. 45 Combined with our findings, we consider that DAT function in the mesolimbic area plays a more important role on morphine-induced craving and memory retrieval than that in the striatum. Therefore, the uptake of 11 C-CFT changed little in the striatum, whereas 18 F-FDG metabolism may reflect the glutamate-receptor-dependent synaptic plasticity of mesolimbic DA neurons.…”

Section: Discussionsupporting

confidence: 83%

“…The modulation of DA neurons for both construction and maintenance of drug-related memories is critically involved in the drugrelated synaptic plasticity. 45 According to this, we conducted 11 C-CFT PET imaging to investigate the DAT change in brain after morphine administration and CPP training. However, we only chose the striatum as the ROI for analysis because the uptake of CFT in other regions is quite low.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Brain glucose metabolism and dopamine transporter changes in rats with morphine‐induced conditioned place preference

et al. 2023

View full text Add to dashboard Cite

Addiction to morphine is a chronic brain disease leading to compulsive abuse. Drug addiction animal models with and without conditioned place preference (CPP) training have been used to investigate cue-elicited drug craving. We used 18 F-fluorodeoxyglucose ( 18 F-FDG) and 11 C-2-β-carbomethoxy-3-β-(4-fluorophenyl) tropane ( 11 C-CFT) micro-PET/CT scans to examine the regional changes in brain glucose metabolism and dopamine transporter (DAT) availability to study their relationship underlying drug memory in morphine-treated rat models with and without CPP.Standardized uptake value ratio (SUVr) of 18 F-FDG significantly decreased in the medial prefrontal cortex (mPFC) and cingulate with short-term morphine administration compared with the baseline condition. Voxelwise analysis indicated glucose metabolism alterations in the somatosensory cortex, hippocampus and cingulate in morphine-treated rats and in the striatum, thalamus, medial prefrontal cortex, primary motor cortex and many regions in the cortex in the CPP group compared with the baseline condition. Alterative glucose metabolism was also observed in the striatum, primary somatosensory cortex and some cortical regions in the CPP group compared with morphine alone group. DAT expression alterations were only observed in the long-term morphine compared with the short-term morphine group. This study shows that cerebral glucose metabolism significantly altered during morphine administration and CPP process mainly in the mPFC, striatum and hippocampus, which indicates that the function of these brain regions is involved in cue-induced craving and memory retrieval.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brain glucose metabolism and dopamine transporter changes in rats with morphine‐induced conditioned place preference

et al. 2023

View full text Add to dashboard Cite

show abstract

“…TPM‐CS was suggested to prevent morphine reinstatement, regulate dopamine and glutamate neurotransmission and avoid cognitive deficits. [ 251 ] Additionally, adenosine 3’, 5’‐monophosphate‐regulated phosphoprotein (DARPP‐32) plays a crucial role in regulating downstream neurobiological alterations following the release of excitatory dopamine and glutamate. DARPP‐32 siRNA therapy has been developed to defeat drug addiction.…”

Section: Pd Approaches: Nanomedicines For Treating Anesthesia‐related...mentioning

confidence: 99%

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Lu,

Wei,

Shi

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Current management of anesthesia‐associated complications falls short in terms of both efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a thorough examination of the existing nanotherapeutics and highlights the strategies for developing prospective nanomedicines to mitigate anesthetics‐related toxicity. Initially, general, regional, and local anesthesia along with the commonly used anesthetics and related prevalent side effects are introduced. Furthermore, employing nanotechnology to prevent and alleviate the complications of anesthetics is systematically demonstrated from three aspects, that is, developing 1) safe nano‐formulization for anesthetics; 2) nano‐antidotes to sequester overdosed anesthetics and alter their pharmacokinetics; 3) nanomedicines with pharmacodynamic activities to treat anesthetics toxicity. Finally, the prospects and challenges facing the clinical translation of nanotherapeutics for anesthesia‐related complications are discussed. This work provides a comprehensive roadmap for developing effective nanotherapeutics to prevent and mitigate anesthesia‐associated toxicity, which can potentially revolutionize the management of anesthesia complications.

show abstract

Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and ΔFosB in the striatum brain area of rats

Milanesi

Rossato

Rosa

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Topiramate-chitosan nanoparticles prevent morphine reinstatement with no memory impairment: Dopaminergic and glutamatergic molecular aspects in rats

Cited by 4 publications

References 81 publications

Brain glucose metabolism and dopamine transporter changes in rats with morphine‐induced conditioned place preference

Brain glucose metabolism and dopamine transporter changes in rats with morphine‐induced conditioned place preference

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and ΔFosB in the striatum brain area of rats

Contact Info

Product

Resources

About