Topiramate as an add‐on antiepileptic drug in treating refractory canine idiopathic epilepsy

Kiviranta, Anna‐Mariam; Laitinen‐Vapaavuori, Outi; Hielm‐Björkman, Anna; Jokinen, Tarja S.

doi:10.1111/jsap.12130

Cited by 20 publications

(28 citation statements)

References 38 publications

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“…According to the described grading system for subject enrolment quality, four studies [ 16 , 24 , 28 , 29 ] enrolled treatment groups of well characterized IE, 11 studies [ 17 - 20 , 25 - 27 , 32 , 33 , 35 , 36 ] enrolled treatment groups of fairly characterized IE and six studies [ 11 , 12 , 14 , 21 , 22 , 30 ] enrolled treatment groups of poorly characterized IE. In five studies [ 13 , 15 , 23 , 31 , 34 ], the diagnostic procedures for enrollment of cases with IE were unclear (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Three of the selected studies evaluated a good number of dogs [ 13 , 14 , 34 ]. Five trials [ 11 , 12 , 15 , 25 , 30 ] and two case series [ 33 , 36 ] evaluated groups with a moderate number of dogs, 14 trials [ 16 , 17 , 19 - 24 , 26 - 29 , 31 , 32 ] evaluated groups with a small number of dogs and one trial [ 18 ] and one case series [ 35 ] evaluated groups with a very small number of dogs. Summaries of the group size for each study are provided in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies reported financial support [ 12 , 15 , 16 , 21 , 24 , 31 , 36 ] but it was judged unclear whether this biased the results. One study [ 17 ] clearly mentioned that there was no financial support, while the remaining 18 studies [ 11 , 13 , 14 , 18 - 20 , 22 , 23 , 25 - 30 , 32 - 35 ] failed to report financial support.…”

Section: Resultsmentioning

confidence: 99%

“…Dewey et al [ 19 ] Fairly Small 10. Kiviranta [ 17 ] Fairly Small 11. Platt et al [ 22 ] Poorly Small 12.…”

Section: Methodsmentioning

confidence: 99%

“…Less than 6 months study duration. Kiviranta [ 17 ] 3 3 3 3 2 2 1 Moderate/high (17) Löscher et al [ 26 ] 3 3 3 3 2 2 3 High (19) Part of the study was retrospective Morton et al [ 31 ] 3 3 3 3 2 2 3 High (19) A few cases were treated by the referring vets. The study had financial support but unclear if it influenced the results.…”

Section: Methodsmentioning

confidence: 99%

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Treatment in canine epilepsy – a systematic review

2014

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BackgroundVarious antiepileptic drugs (AEDs) are used for the management of canine idiopathic epilepsy (IE). Information on their clinical efficacy remains limited. A systematic review was designed to evaluate existing evidence for the effectiveness of AEDs for presumptive canine IE. Electronic searches of PubMed and CAB Direct were carried out without date or language restrictions. Conference proceedings were also searched. Peer-reviewed full-length studies describing objectively the efficacy of AEDs in dogs with IE were included. Studies were allocated in two groups, i.e. blinded randomized clinical trials (bRCTs), non-blinded randomized clinical trials (nbRCTs) and non-randomized clinical trials (NRCTs) (group A) and uncontrolled clinical trials (UCTs) and case series (group B). Individual studies were evaluated based on the quality of evidence (study design, study group sizes, subject enrolment quality and overall risk of bias) and the outcome measures reported (in particular the proportion of dogs with ≥50% reduction in seizure frequency).ResultsTwenty-six studies, including two conference proceedings, reporting clinical outcomes of AEDs used for management of IE were identified. Heterogeneity of study designs and outcome measures made meta-analysis inappropriate. Only four bRCTs were identified in group A and were considered to offer higher quality of evidence among the studies. A good level of evidence supported the efficacy of oral phenobarbital and imepitoin and fair level of evidence supported the efficacy of oral potassium bromide and levetiracetam. For the remaining AEDs, favorable results were reported regarding their efficacy, but there was insufficient evidence to support their use due to lack of bRCTs.ConclusionsOral phenobarbital and imepitoin in particular, as well as potassium bromide and levetiracetam are likely to be effective for the treatment of IE. However, variations in baseline characteristics of the dogs involved, significant differences between study designs and several potential sources of bias preclude definitive recommendations. There is a need for greater numbers of adequately sized bRCTs evaluating the efficacy of AEDs for IE.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Dewey et al [ 19 ] Fairly Small 10. Kiviranta [ 17 ] Fairly Small 11. Platt et al [ 22 ] Poorly Small 12.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Treatment in canine epilepsy – a systematic review

2014

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Antiepileptics

Cook,

Hechler

2024

Pharmacology in Veterinary Anesthesia and Analgesia

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Idiosyncratic reaction of topiramate in a Maine Coon cat

Du¹,

Draper²

2021

Vet Record Case Reports

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A 1.5‐year‐old Main Coon neutered male cat was presented for cluster epileptic seizures. The cat was first treated with phenobarbital; however, it had to be discontinued due to anticonvulsant hypersensitivity syndrome. Topiramate was then initiated. Shortly thereafter, a persistent neutropenia developed and the topiramate was stopped. The epileptic seizures are now adequately controlled by levetiracetam extended release 500 mg every 12 hours and the neutropenia had resolved. This is the first report of adverse drug reaction of topiramate in cats.

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Topiramate as an add‐on antiepileptic drug in treating refractory canine idiopathic epilepsy

Abstract: Topiramate may be effective as an add-on medication in treating canine idiopathic epilepsy. Apart from sedation and ataxia reported in some of the dogs, topiramate was well-tolerated.

Cited by 20 publications

References 38 publications

Treatment in canine epilepsy – a systematic review

Treatment in canine epilepsy – a systematic review

Antiepileptics

Idiosyncratic reaction of topiramate in a Maine Coon cat

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