2005
DOI: 10.5070/d342s4b398
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Topiramate and scars

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Cited by 3 publications
(4 citation statements)
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“…An excellent response (more than 75% improvement) was reported in all cases with PVS within the third month of treatment. PVS showed the greatest improvement among other scars to oral topiramate, followed by acne scars with good to excellent results for 93% of cases ( 14 ).…”
Section: Resultsmentioning
confidence: 98%
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“…An excellent response (more than 75% improvement) was reported in all cases with PVS within the third month of treatment. PVS showed the greatest improvement among other scars to oral topiramate, followed by acne scars with good to excellent results for 93% of cases ( 14 ).…”
Section: Resultsmentioning
confidence: 98%
“…Combination therapies including intradermal incision with Er:YAG and also, Microdermabrasion with Nd:YAG laser, were also effective, resulting in marked improvements ( 37 , 38 ). In systemic medical treatments, the off-label use of topiramate and isotretinoin revealed marked improvements, but they are used limitedly in practice ( 13 , 14 ).…”
Section: Discussionmentioning
confidence: 99%
“…It acts on multiple molecular targets, which may explain why it is effective, not only in epilepsy, but also in several others neurological conditions (Silberstein, 2017). In previous studies, oral TPM resulted in improved aesthetic aspect of scars and improved the quality of scars from acne and varicella (Bharti & Agarwal, 2005;Shapira et al, 2003). Although the systemic use of TPM has some limited side effects, it is considered a safe medication (Arnone, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, research has shown that TPM increases the anorexigenic signals in the hypothalamus by increasing insulin-induced insulin receptor (IR), insulin receptor substrate-1 (IRS-1) and protein kinase B (PKB or Akt) activity, and the activity of the leptin-activated mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway (Caricilli et al, 2012). Topical TPM can also improve the aspect of scars produced by trauma, varicella, dermatitis, and acne (Bharti & Agarwal, 2005; Shapira, Lessig, Murphy, Annis, & Lazoritz, 2003). Further research has shown TPM to be effective in treating psoriasis (Ryback, 2002).…”
mentioning
confidence: 99%