Topiramate and scars

Bharti, Rakesh; Agarwal, Lovedhi

doi:10.5070/d342s4b398

Cited by 3 publications

(4 citation statements)

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“…An excellent response (more than 75% improvement) was reported in all cases with PVS within the third month of treatment. PVS showed the greatest improvement among other scars to oral topiramate, followed by acne scars with good to excellent results for 93% of cases ( 14 ).…”

Section: Resultsmentioning

confidence: 98%

“…Combination therapies including intradermal incision with Er:YAG and also, Microdermabrasion with Nd:YAG laser, were also effective, resulting in marked improvements ( 37 , 38 ). In systemic medical treatments, the off-label use of topiramate and isotretinoin revealed marked improvements, but they are used limitedly in practice ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

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Varicella-Zoster Scar Treatments: A Tertiary Review

Mohammad

Ghassemi

2021

Med. J. Islam. Republ. Iran

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Varicella-Zoster Scar Treatments: A Tertiary Review

Mohammad

Ghassemi

2021

Med. J. Islam. Republ. Iran

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“…It acts on multiple molecular targets, which may explain why it is effective, not only in epilepsy, but also in several others neurological conditions (Silberstein, 2017). In previous studies, oral TPM resulted in improved aesthetic aspect of scars and improved the quality of scars from acne and varicella (Bharti & Agarwal, 2005;Shapira et al, 2003). Although the systemic use of TPM has some limited side effects, it is considered a safe medication (Arnone, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, research has shown that TPM increases the anorexigenic signals in the hypothalamus by increasing insulin-induced insulin receptor (IR), insulin receptor substrate-1 (IRS-1) and protein kinase B (PKB or Akt) activity, and the activity of the leptin-activated mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway (Caricilli et al, 2012). Topical TPM can also improve the aspect of scars produced by trauma, varicella, dermatitis, and acne (Bharti & Agarwal, 2005; Shapira, Lessig, Murphy, Annis, & Lazoritz, 2003). Further research has shown TPM to be effective in treating psoriasis (Ryback, 2002).…”

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confidence: 99%

Topical Topiramate Improves Wound Healing in an Animal Model of Hyperglycemia

Jara

Prado

Bóbbo

et al. 2019

Biological Research For Nursing

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Wound healing is severely affected in hyperglycemia and other metabolic conditions. Finding new therapeutic approaches that accelerate wound healing and improve the quality of the scar may reduce the morbidity commonly associated with skin lesions in diabetes. This study evaluated the effect of topical topiramate (TPM) on wound healing in C57 mice. Streptozotocin-induced hyperglycemic mice were subjected to a wound on the back and randomly allocated for treatment with either vehicle or topical TPM cream (2%) once a day for 14 days. Polymerase chain reaction, Western blotting, and microscopy were performed for the analysis. TPM improved wound healing (complete resolution at Day 10, 98% ± 5 for TPM vs. 81% ± 28 for vehicle), increased organization and deposition of collagen Type I, and enhanced the quality of the scars as determined by microscopy. In addition, TPM modulated the expression of cytokines and proteins of the insulin-signaling pathway: In early wound-healing stages, expression of interleukin-10, an anti-inflammatory marker, increased, whereas at the late phase, the pro-inflammatory markers tumor necrosis factor-α and monocyte chemoattractant protein-1 increased and there was increased expression of a vascular endothelial growth factor. Proteins of the insulin-signaling pathway were stimulated in the late wound-healing phase. Topical TPM improves the quality of wound healing in an animal model of hyperglycemia. The effect of TPM is accompanied by modulation of inflammatory and growth factors and proteins of the insulin-signaling pathway. Therefore, topical TPM presents as a potential therapeutic agent in skin wounds in patients with hyperglycemia.

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Topiramate-Positive Death-Investigation and Impaired-Driving Cases in Washington State

Gordon¹,

Logan²

2006

Journal of Analytical Toxicology

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Topiramate (Topamax), an effective seizure disorder treatment, received additional FDA approval for prevention of migraine headaches in August 2004 and has gained attention for its off-label uses, including psychiatric and eating disorders, neuropathic pain, and alcohol and drug dependency. Side effects of sedation, dizziness, ataxia, speech difficulty, nystagmus, paresthesia, and metabolic acidosis are described. The manufacturer reports that tolerance to the antiseizure properties does not develop. With its established efficacy for epilepsy treatment and its increased use for other disorders, topiramate-positive findings are more common in death-investigation and human-performance casework. To evaluate the role of topiramate, we reviewed all topiramate-positive cases from our laboratory between 1998 and 2004, which constituted 132 cases (63 death investigations, 68 suspected impaired drivers, and 1 sexual assault case). The subjects were predominantly female (69%) with a mean and median age of 42. Blood topiramate concentrations ranged from 1 to 180 mg/L (median 6.4 mg/L, mean 8.4 mg/L), and 94% were positive for at least one additional drug. There was evidence of psychomotor impairment in some drivers with blood concentrations within the normal therapeutic range, and deaths attributed to topiramate alone occurred at concentrations as low as 50 mg/L.

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Topiramate and scars

Cited by 3 publications

References 0 publications

Varicella-Zoster Scar Treatments: A Tertiary Review

Varicella-Zoster Scar Treatments: A Tertiary Review

Topical Topiramate Improves Wound Healing in an Animal Model of Hyperglycemia

Topiramate-Positive Death-Investigation and Impaired-Driving Cases in Washington State

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