Topically Applied Niacinamide in Isoniazid-Induced Pellagra

Comaish, J.S.; Felix, R; McGrath, H

doi:10.1001/archderm.1976.01630250034010

Cited by 18 publications

(5 citation statements)

References 8 publications

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“…11 were able to observe complete remission of an isoniazid-induced pellagra following topical treatment with niacinamide. 11 One per cent niacinamide was used in a macrogol ointment. To our knowledge, there have been no reports in the literature of beneficial effects as a result of the systemic use of niacinamide in the case of isoniazid-induced pellagra.…”

Section: Topical Application Of Niacinamide In Isoniazid-induced Pellmentioning

confidence: 97%

“…The complex formation between isoniazid and pyridoxal phosphate can then lead to inhibition of the synthesis of nicotinic acid from tryptophan 10 . Comaish et al 11 . were able to observe complete remission of an isoniazid‐induced pellagra following topical treatment with niacinamide 11 .…”

Section: Uses Of Niacinamidementioning

confidence: 99%

“…Comaish et al 11 . were able to observe complete remission of an isoniazid‐induced pellagra following topical treatment with niacinamide 11 . One per cent niacinamide was used in a macrogol ointment.…”

Section: Uses Of Niacinamidementioning

confidence: 99%

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Nicotinic acid/niacinamide and the skin

Gehring

2004

J of Cosmetic Dermatology

115

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Nicotinic acid (also generally known as niacin) and niacinamide (also known as nicotinamide) are similarly effective as a vitamin because they can be converted into each other within the organism. The blanket term vitamin B(3) is used for both. Niacinamide is a component of important coenzymes involved in hydrogen transfer. Here, the two codehydrogenases, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are of central importance. Topical application of niacinamide has a stabilizing effect on epidermal barrier function, seen as a reduction in transepidermal water loss and an improvement in the moisture content of the horny layer. Niacinamide leads to an increase in protein synthesis (e.g. keratin), has a stimulating effect on ceramide synthesis, speeds up the differentiation of keratinocytes, and raises intracellular NADP levels. In ageing skin, topical application of niacinamide improves the surface structure, smoothes out wrinkles and inhibits photocarcinogenesis. It is possible to demonstrate anti-inflammatory effects in acne, rosacea and nitrogen mustard-induced irritation. Because of its verifiable beneficial effects, niacinamide would be a suitable component in cosmetic products for use in disorders of epidermal barrier function, for ageing skin, for improving pigmentary disorders and for use on skin prone to acne.

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Section: Topical Application Of Niacinamide In Isoniazid-induced Pellmentioning

confidence: 97%

Section: Uses Of Niacinamidementioning

confidence: 99%

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Nicotinic acid/niacinamide and the skin

Gehring

2004

J of Cosmetic Dermatology

115

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“…Niacinamide (NIA) is the water-soluble form of vitamin B3 and the amide form of nicotinic acid [9]. In 1976, Comaish et al [10] first reported NIA as an efficient treatment for pellagra, a vitamin deficiency disease with dermatitis symptoms. Since then, topical application of NIA has been shown to improve various skin conditions in humans.…”

Section: Introductionmentioning

confidence: 99%

An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery of Niacinamide

Zhang¹,

Lane²,

Moore³

2020

Polymers

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Polyethylene glycols (PEGs) and PEG derivatives are used in a range of cosmetic and pharmaceutical products. However, few studies have investigated the influence of PEGs and their related derivatives on skin permeation, especially when combined with other solvents. Previously, we reported niacinamide (NIA) skin permeation from a range of neat solvents including propylene glycol (PG), Transcutol® P (TC), dimethyl isosorbide (DMI), PEG 400 and PEG 600. In the present work, binary and ternary systems composed of PEGs or PEG derivatives combined with other solvents were investigated for skin delivery of NIA. In vitro finite dose studies were conducted (5 μL/cm2) in porcine skin over 24 h. Higher skin permeation of NIA was observed for all vehicles compared to PEG 400. However, overall permeation for the binary and ternary systems was comparatively low compared with results for PG, TC and DMI. Interestingly, values for percentage skin retention of NIA for PEG 400:DMI and PEG 400:TC were significantly higher than values for DMI, TC and PG (p < 0.05). The findings suggest that PEG 400 may be a useful component of formulations for the delivery of actives to the skin rather than through the skin. Future studies will expand the range of vehicles investigated and also look at skin absorption and residence time of PEG 400 compared to other solvents.

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“…dermatitis, diarrhoea, dementia, and death) has re-ignited considerable interest on the mechanism of action of NAD + and its key metabolites. [3][4][5][6][7] Intriguingly, with the understanding of the pharmacological role of niacins was the almost simultaneous discovery of the structure and function of NAD + by four Nobel laureates. 8 In 1904, Sir Arthur Harden separated Buchner's yeast juice into a high-and low-molecular-weight fraction, neither of which could undergo fermentation individually.…”

Section: Introductionmentioning

confidence: 99%

NAD⁺metabolism and oxidative stress: the golden nucleotide on a crown of thorns

et al. 2012

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In the twentieth century, NAD+ research generated multiple discoveries. Identification of the important role of NAD+ as a cofactor in cellular respiration and energy production was followed by discoveries of numerous NAD+ biosynthesis pathways. In recent years, NAD+ has been shown to play a unique role in DNA repair and protein deacetylation. As discussed in this review, there are close interactions between oxidative stress and immune activation, energy metabolism, and cell viability in neurodegenerative disorders and ageing. Profound interactions with regard to oxidative stress and NAD+ have been highlighted in the present work. This review emphasizes the pivotal role of NAD+ in the regulation of DNA repair, stress resistance, and cell death, suggesting that NAD+ synthesis through the kynurenine pathway and/or salvage pathway is an attractive target for therapeutic intervention in age-associated degenerative disorders. NAD+ precursors have been shown to slow down ageing and extend lifespan in yeasts, and protect severed axons from degeneration in animal models neurodegenerative diseases.

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Topically Applied Niacinamide in Isoniazid-Induced Pellagra

Cited by 18 publications

References 8 publications

Nicotinic acid/niacinamide and the skin

Nicotinic acid/niacinamide and the skin

An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery of Niacinamide

NAD⁺metabolism and oxidative stress: the golden nucleotide on a crown of thorns

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Topically Applied Niacinamide in Isoniazid-Induced Pellagra

Cited by 18 publications

References 8 publications

Nicotinic acid/niacinamide and the skin

Nicotinic acid/niacinamide and the skin

An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery of Niacinamide

NAD+metabolism and oxidative stress: the golden nucleotide on a crown of thorns

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Product

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NAD⁺metabolism and oxidative stress: the golden nucleotide on a crown of thorns