Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn

Wang, Cheng Z.; Ayadi, Amina El; Goswamy, Juhi; Finnerty, Celeste C.; Mifflin, Randy C.; Sousse, Linda E.; Enkhbaatar, Perenlei; Papaconstantinou, John; Herndon, David N.; Ansari, Naseem H.

doi:10.1016/j.burns.2015.08.012

Cited by 24 publications

(43 citation statements)

References 53 publications

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“…For instance, topical EDTA-MSM is effective at reducing oxidative damage in the form of protein-lipid aldehyde adducts [170,171,172]. EDTA-MSM reduced lens opacification in diabetic cataract [172] but was ineffective in reversing experimentally induced intraocular pressure in rats [170].…”

Section: Common Usesmentioning

confidence: 99%

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Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

Benjamin²,

2017

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Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety of purposes, including its most common use as an anti-inflammatory agent. It has been well-investigated in animal models, as well as in human clinical trials and experiments. A variety of health-specific outcome measures are improved with MSM supplementation, including inflammation, joint/muscle pain, oxidative stress, and antioxidant capacity. Initial evidence is available regarding the dose of MSM needed to provide benefit, although additional work is underway to determine the precise dose and time course of treatment needed to provide optimal benefits. As a Generally Recognized As Safe (GRAS) approved substance, MSM is well-tolerated by most individuals at dosages of up to four grams daily, with few known and mild side effects. This review provides an overview of MSM, with details regarding its common uses and applications as a dietary supplement, as well as its safety for consumption.

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Section: Common Usesmentioning

confidence: 99%

“…Another final study report indicated that MSM may be slightly irritating to skin of guinea pigs. Using a lotion containing EDTA and MSM, mild improvement in burn sites on rats were noticed following three days of topical application every 8 h [171]. …”

Section: Common Usesmentioning

confidence: 99%

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

Benjamin²,

2017

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“…Lessening the impact of the extensive scarring that affects 70–90% of severely burned patients has become a research priority, prompting the development of reliable animal models to study post-burn wound healing and hypertrophic scarring (15, 18, 91, 92) to parallel studies of the patients themselves.…”

Section: Post-burn Hypertrophic Scarringmentioning

confidence: 99%

The P50 Research Center in Perioperative Sciences

Finnerty

Čapek

Voigt

et al. 2017

Journal of Trauma and Acute Care Surgery

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Since the inception of the P50 Research Center in Peri-Operative Sciences (RCIPS) funding mechanism, the National Institute for General Medical Sciences has supported a team approach to science. Many advances in critical care, particularly burns, have been driven by RCIPS teams. In fact, burns that were fatal in the early 1970s, prior to the inception of the P50 RCIPS program, are now routinely survived as a result of the P50-funded research. The advances in clinical care that led to the reduction in post-burn death were made by optimizing resuscitation, incorporating early excision and grafting, bolstering acute care including support for inhalation injury, modulating the hypermetabolic response, augmenting the immune response, incorporating aerobic exercise, and developing anti-scarring strategies. The work of the Burn RCIPS programs advanced our understanding of the pathophysiological response to burn injury. As a result, the effects of a large burn on all organ systems have been studied, leading to the discovery of persistent dysfunction, elucidation of the underlying molecular mechanisms, and identification of potential therapeutic targets. Survival and subsequent patient satisfaction with quality of life have increased. In this review article, we describe the contributions of the Galveston P50 RCIPS that have changed post-burn care and have considerably reduced post-burn mortality.

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“…While collagen, necessary for chondrocytes and osteoblasts, can promote the adhesion and migration of bone cells, the formation of collagen matrix, and the reconstruction of bone tissue[10, 11]. However, MSM is easily metabolized and excreted, which lead to short duration of efficacy[12-14].…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of Bone Defect Based on the Fusion of Osteoblasts and MSM/HA/PLGA Porous Scaffolds

Zheng

et al. 2020

Preprint

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Reconstruction of bone defect is one of the difficult problems in orthopedic treatment, and bone tissue scaffold implantation is the most promising direction of bone defect reconstruction. In this study, we used the combination of HA (Hydroxyapatite) and PLGA [Poly (lacticco-glycolic acid)] in the construction of polymer scaffolds, and introduced bioactive MSM (Methyl sulfonyl methane) into polymer scaffolds to prepare porous scaffolds. The osteoblasts, isolated and cultured in vitro, were seeded in the porous scaffolds to construct tissue-engineered scaffolds. Meanwhile, the model of rabbit radius defect was constructed to evaluate the biological aspects of five tissue-engineered scaffolds, which provided experimental basis for the application of the porous scaffolds in bone tissue engineering. The SEM characterization showed the pore size of porous scaffolds was uniform and the porosity was about 90%. The results of contact Angle testing suggested that the hydrophobic porous scaffold surface could effectively promote cell adhesion and cell proliferation, while mechanical property test showed good machinability. The results of drug loading and release efficiency of MSM showed that porous scaffolds could load MSM efficiently and prolong the release time of MSM. In vitro incubation of porous scaffolds and osteoblasts showed that the addition of a small quantity of MSM could promote the infiltration and proliferation of osteoblasts on the porous scaffolds. Similar results were obtained by implanting the tissueengineered scaffolds, fused with the osteoblasts and MSM/HA/PLGA porous scaffolds, into the rabbit radius defect, which provided experimental basis for the application of the MSM/HA/PLGA porous scaffolds in bone tissue engineering.

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Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn

Cited by 24 publications

References 53 publications

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

The P50 Research Center in Perioperative Sciences

Reconstruction of Bone Defect Based on the Fusion of Osteoblasts and MSM/HA/PLGA Porous Scaffolds

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