Topical Zinc Oxide Treatment Increases Endogenous Gene Expression of Insulin-Like Growth Factor-1 in Granulation Tissue from Porcine Wounds

Tarnow, Peter; Ågren, Magnus S.; Steenfos, Henrik; Jansson, John‐Olov

doi:10.3109/02844319409022008

Cited by 38 publications

(13 citation statements)

References 25 publications

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“…Experiments have been carried out in nutritionally balanced domestic pigs to substantiate the therapeutic value of zinc oxide supplement in wound healing and its putative mechanisms of action 126 . We could demonstrate 30% promotion of healing by topical zinc oxide in both partial‐thickness and full‐thickness wounds 126–128 . Whereas supplementary zinc oxide advanced epithelialization significantly in these experiments, topical zinc sulfate offered no benefits on wound healing (Figure 1).…”

Section: Zinc In Wound‐healing Physiologymentioning

confidence: 85%

Zinc in wound healing: Theoretical, experimental, and clinical aspects

Lansdown

Mirastschijski

Stubbs

et al. 2007

Wound Repair Regeneration

544

416

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Zinc is an essential trace element in the human body and its importance in health and disease is appreciated. It serves as a cofactor in numerous transcription factors and enzyme systems including zinc-dependent matrix metalloproteinases that augment autodebridement and keratinocyte migration during wound repair. Zinc confers resistance to epithelial apoptosis through cytoprotection against reactive oxygen species and bacterial toxins possibly through antioxidant activity of the cysteine-rich metallothioneins. Zinc deficiency of hereditary or dietary cause can lead to pathological changes and delayed wound healing. Oral zinc supplementation may be beneficial in treating zinc-deficient leg ulcer patients, but its therapeutic place in surgical patients needs further clarification. Topical administration of zinc appears to be superior to oral therapy due to its action in reducing superinfections and necrotic material via enhanced local defense systems and collagenolytic activity, and the sustained release of zinc ions that stimulates epithelialization of wounds in normozincemic individuals. Zinc oxide in paste bandages (Unna boot) protects and soothes inflamed peri-ulcer skin. Zinc is transported through the skin from these formulations, although the systemic effects seem insignificant. We present here the first comprehensive account of zinc in wound management in relation to current concepts of wound bed preparation and the wound-healing cascade. This review article suggests that topical zinc therapy is underappreciated even though clinical evidence emphasizes its importance in autodebridement, anti-infective action, and promotion of epithelialization.

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Section: Zinc In Wound‐healing Physiologymentioning

confidence: 85%

Zinc in wound healing: Theoretical, experimental, and clinical aspects

Lansdown

Mirastschijski

Stubbs

et al. 2007

Wound Repair Regeneration

544

416

View full text Add to dashboard Cite

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“…Meanwhile, the concentration is sufficient for wound healing effects. [5][6][7][8] The increasing interest in aqueous colloidal nanogels or microgels 9 in the past decades is due to many useful applications such as coatings, agriculture, medicine, etc., which a)…”

Section: Introductionmentioning

confidence: 99%

Synthesis of hybrid microgels by coupling of laser ablation and polymerization in aqueous medium

Nachev

Zand

Coger

et al. 2012

Journal of Laser Applications

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Loading microgels with bioactive nanoparticles (NPs) often requires multiple synthesis and purification steps, and organic solvents or precursors that are difficult to remove from the gel. Hence, a fast and aqueous synthesis procedure would facilitate the synthesis of inorganic–organic hybrid microgels. Two microgel compounds were hybridized with laser-generated zinc oxide (ZnO) NPs prepared in a single-step procedure. ZnO NPs were formed by laser ablation in liquid, while the polymer microgels were synthesized in-situ inside the ablation chamber. Further, the authors report the preparation of two different microgel systems. The first one was produced without the use of chemical initiator forming hydrogels with ZnO NPs and diffuse morpholgy. Typical microgel colloids were also synthesized via a conventional chemical method in a preheated reaction chamber. The existence of microgel colloids partially loaded with ZnO NPs was confirmed in a transmission electron microscopy investigation. Fourier transform infrared spectroscopic measurements and dynamic light scattering verify the formation of polymer colloids. These initial results indicate the application potential of laser ablation in microgel precursor solution for the fabrication of polymeric carriers for inorganic nanoparticles. Preliminary biological tests using zinc chloride demonstrated negative dose effects on primary cell culture with zinc concentrations above 200 μM but no noticeable influence at 100 μM.

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“…32 Additionally, studies have demonstrated the ability of topical zinc oxide to enhance healing in skin. 33,34 This skin protectant is effective for prophylaxis or treatment of mild diaper dermatitis, but when the involved skin is more severely affected, an antifungal agent and low-potency topical corticosteroid such as hydrocortisone may be used as well. 24 However, as previously discussed, current antifungal-corticosteroid combination preparations contain potent, halogenated corticosteroids that are contraindicated for use in diaper dermatitis.…”

Section: Methodsmentioning

confidence: 99%