Topical zinc oxide: breaking the vicious cycle of erosive pustular dermatosis of the scalp

Altobrando, Ambra Di; Tabanelli, Michela

doi:10.1111/ijd.15867

Cited by 5 publications

(4 citation statements)

References 5 publications

(15 reference statements)

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“…However, Di Altobrando et al (51) found that topical zinc oxide may be a unitary, effective, and inexpensive strategy for the chronic therapy of EPD of the legs. The efficacy of zinc oxide in erosive pustular dermatosis of the scalp was also validated in a later study by Di Altobrando et al (52).…”

Section: Erosive Pustular Dermatosismentioning

confidence: 80%

Trace element zinc and skin disorders

Pan

Yang

et al. 2023

Front. Med.

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Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except for acrodermatitis enteropathic, a rare genetic zinc deficiency, it has also been reported in other diseases. In recent years, zinc supplementation has been widely used for various skin conditions, including infectious diseases (viral warts, genital herpes, cutaneous leishmaniasis, leprosy), inflammatory diseases (hidradenitis suppurativa, acne vulgaris, rosacea, eczematous dermatitis, seborrheic dermatitis, psoriasis, Behcet's disease, oral lichen planus), pigmentary diseases (vitiligo, melasma), tumor-associated diseases (basal cell carcinoma), endocrine and metabolic diseases (necrolytic migratory erythema, necrolytic acral erythema), hair diseases (alopecia), and so on. We reviewed the literature on zinc application in dermatology to provide references for better use.

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Section: Erosive Pustular Dermatosismentioning

confidence: 80%

Trace element zinc and skin disorders

Pan

Yang

et al. 2023

Front. Med.

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“…Scalp EPD therapy also remains a product of the individual approach of the clinician and has undergone some evolution in recent years. The therapeutic options described in the world literature are variable and include 1) topical zink oxide (24), 2) the systemic application of sulfasalazine in combination with 308 nm monochromatic excimer light (25), 3) oral application of retinoid and a bi-layered skin substitute (26), local application of novel silicone gel (27), local treatment with 0.1% mometasone furoate cream (28), systemic therapy with oral prednisone and topical tacrolimus (29), local monotherapy with tacrolimus (30), systemic dapsone therapy ( 31), systemic therapy with acitretin (32), photodynamic therapy (33), isotretinoin systemically (34), local therapy with calcipotriol cream (35) and oral zinc sulphate (36). First-line therapy remains the local application of potent corticosteroids and topical calcineurin inhibitors (2).…”

Section: Discussionmentioning

confidence: 99%

“…The therapeutic options described in the world literature are variable and include i) topical zink oxide, 21 ii) the systemic application of sulfasalazine in combination with 308 nm monochromatic excimer light, 22 iii) oral application of retinoid and a bi-layered skin substitute, 23 local application of novel silicone gel, 24 local treatment with 0.1% mometasone furoate cream, 25 systemic therapy with oral prednisone and topical tacrolimus, 26 local monotherapy with tacrolimus, 27 systemic dapsone therapy, 28 systemic therapy with acitretin, 29 photodynamic therapy, 30 isotretinoin systemically, 31 local therapy with calcipotriol cream, 32 and oral zinc sulphate. 33 …”

Section: Discussionmentioning

confidence: 99%

Erosive pustular dermatosis of the scalp: a pathogenetic мystery and therapeutic challenge

Tchernev¹,

Kordeva²,

Batashki³

et al. 2022

Dermatol Reports

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Erosive pustular dermatosis of the scalp (EPDS) is a rare condition which affects predominantly the adult population, and occurs on a previously photo-damaged bald scalp. The physical examination is presented with a large erythematous, erosive and crusted patches with granulation on an atrophic skin. The problem in patients with erosive pustular dermatosis of the scalp arises from the nonspecific clinical and histopathological findings, which can be misleading. Biopsy followed by careful histopathological verification is mandatory, although the finding is nonspecific.The histopathology findings are characterized by superficial erosions with mild neutrophil infiltrate, mainly intravascular and focally with neutrophil exocytosis. Focal parakeratosis, smoothed rete ridges without pronounced interface changes. Pronounced lymphoplasmacytic infiltrate with focal distribution in the dermis, giant cell reaction with the formation of a “foreign body” granuloma. We report a 58-year old male patient with a 1 year old lesion, suspected for skin cancer, later diagnosed with EPDS, which was successfully treated with topical clobetasol proprionate after 3-5 weeks.

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“…Calcipotriol cream has been effective in a case report but is limited by its slow action [78]. Recently, topical zinc oxide was effective in case reports and may be combined with other topical and/or systemic therapies for enhanced outcomes [79,80].…”

Section: Other Topical Treatmentsmentioning

confidence: 99%

Erosive Pustular Dermatosis: Delving into Etiopathogenesis and Management

Bhargava

Yumeen

Henebeng

et al. 2022

Life

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Erosive pustular dermatosis (EPD) is a chronic inflammatory skin disorder that usually affects mature individuals. It predominantly affects the scalp and can lead to scarring alopecia. Risk factors include actinic damage and androgenetic alopecia. A traumatic insult to the skin is considered a vital trigger of the condition. EPD is a diagnosis of exclusion; thus, several neoplastic, infectious, vesiculobullous, and inflammatory conditions should be ruled out. Biopsy and clinicopathologic correlation are required to differentiate between EPD and these entities. A dysregulated, chronic immune response is considered central to the etiopathogenesis of EPD. We performed an evidence-based systematic review of the management options. There were predominantly studies with level IV and V evidence and only two with level III. Despite the responsiveness of EPD to potent topical steroids, such as clobetasol propionate, recurrence occurs after treatment withdrawal. With the available data, tacrolimus 0.1%, curettage-assisted aminolevulinic acid-photodynamic therapy, and systemic retinoids can be considered second-line options for EPD with a role in maintenance regimens. However, controlled data and more powerful studies are needed to make solid recommendations.

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Topical zinc oxide: breaking the vicious cycle of erosive pustular dermatosis of the scalp

Cited by 5 publications

References 5 publications

Trace element zinc and skin disorders

Trace element zinc and skin disorders

Erosive pustular dermatosis of the scalp: a pathogenetic мystery and therapeutic challenge

Erosive Pustular Dermatosis: Delving into Etiopathogenesis and Management

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