Topical vitamin D analogues alone or in association with topical steroids for psoriasis: a systematic review

Devaux, S.; Castela, Ângela; Archier, E.; Gallini, Adeline; Joly, P.; Miséry, Laurent; Aractingi, S.; Aubin, F.; Bachelez, Hervé; Cribier, B.; Jullien, D.; Maître, Michel; Richard, M.‐A.; Ortonne, Jean‐Paul; Paul, C.

doi:10.1111/j.1468-3083.2012.04524.x

Cited by 47 publications

(29 citation statements)

References 60 publications

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“…Topical formulations containing corticosteroids and/or vitamin D 3 analogues are recommended for treating psoriasis 7, 8, 13, 14, 15. The efficacy and safety of the fixed combination of calcipotriol 50 μg/g (Cal) and betamethasone 0.5 mg/g as dipropionate (BD) has been confirmed in long‐term trials 16, 17, 18, 19.…”

Section: Introductionmentioning

confidence: 99%

Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO‐ABLE study

Paul

Gold

Cambazard

et al. 2016

Acad Dermatol Venereol

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167

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BackgroundFixed combination calcipotriol 50 μg/g (Cal) plus betamethasone 0.5 mg/g (BD) foam has been developed as a new treatment option for patients with psoriasis.MethodsThe randomized, parallel‐group, investigator‐blinded Phase III, 12‐week PSO‐ABLE study compared the efficacy and safety of Cal/BD foam with Cal/BD gel. Patients aged ≥18 years with mild‐to‐severe psoriasis were randomized 4:4:1:1 to once‐daily Cal/BD foam, Cal/BD gel, foam vehicle or gel vehicle (NCT02132936). The primary efficacy endpoint was the proportion of patients who were clear/almost clear with a ≥ 2 grade improvement according to the physician's global assessment of disease severity (i.e. treatment success) at week 4 for Cal/BD foam vs. week 8 for Cal/BD gel. Secondary efficacy endpoints included: proportion of patients achieving at least a 75% reduction in modified psoriasis area and severity index (mPASI75), and time to treatment success (TTTS). Safety was monitored throughout.ResultsA total of 463 patients were randomized: Cal/BD foam (n = 185), Cal/BD gel (n = 188), foam vehicle (n = 47), gel vehicle (n = 43); overall completion rate was 90%. Cal/BD foam achieved higher treatment success rates (38% vs. 22%; P < 0.001) and mPASI75 (52% vs. 35%; P < 0.001) by week 4 than Cal/BD gel by week 8. Median TTTS with Cal/BD foam was 6 weeks; this could not be determined for Cal/BD gel as 50% treatment success was not achieved (P < 0.001). Adverse drug reactions were reported in 14 (7.6%) Cal/BD aerosol foam patients and 7 (3.7%) Cal/BD gel patients; all were single events except for itch with Cal/BD aerosol foam (n = 5; 2.7%) and worsening psoriasis with Cal/BD gel (n = 3; 1.6%).ConclusionCal/BD aerosol foam showed significantly greater efficacy after 4 weeks, than 8 weeks of treatment with Cal/BD gel, with similar tolerability.

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Section: Introductionmentioning

confidence: 99%

Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO‐ABLE study

Paul

Gold

Cambazard

et al. 2016

Acad Dermatol Venereol

Self Cite

167

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“…[38][39][40] Montelukast is the preferred leukotriene modifier in patients with asthma and sickle cell disease because of its wellestablished effects on the improvements of asthma symptoms, once daily dosing, and its safety record (similar to placebo) that extends over 10 years of use in millions of patients. 41 However, montelukast use has been associated with behavior changes, which may be relevant when considering use in the child with sickle cell disease. Agitation, aggressive behavior or hostility, anxiousness, depression, dream abnormalities, hallucinations, insomnia, irritability, restlessness, somnambulism, suicidal thinking and behavior (including suicide), and tremor may occur with montelukast use.…”

Section: Leukotriene Modifiersmentioning

confidence: 99%

Considerations for Care: Management of Asthma in the Child with Sickle Cell Disease

Blake¹,

Raissy²

2013

Pediatric Allergy, Immunology, and Pulmonology

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“…61,62 Na psoríase a utilização tópica de calcipotriol é eficaz nas formas moderadas de psoríase, e a associação com dermocorticóides é tratamento de 1ª linha quando há menos de 10% de superfície corporal atingida. 63 A vitamina D oral deveria ser considerada, pela sua ação sinérgica com as terapêuticas orais convencionais. 64 Na dermatite atópica os dados são contraditórios.…”

Section: Níveis Adequados De Vitamina Dunclassified

Vitamina D – Perspetivas Atuais

Catarino

Claro

Viana

2016

SPDV

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RESUMO -A vitamina D tem como efeito biológico principal a promoção da mineralização óssea e a regulação da homeostasia do metabolismo cálcio-fósforo. A sua função biológica extra-esqueleto tem sido amplamente estudada e o seu défice associado a risco aumentado para diversas patologias, nomeadamente autoimunes, neoplásicas, cardiovasculares e neurológicas, entre outras. No entanto, esta mantém-se uma área de controvérsia e está por demonstrar a relação causa-efeito entre deficiência de vitamina D e patologia não esquelética, e o benefício da suplementação com esse objetivo. Nos indivíduos em risco de hipovitaminose a suplementação é segura, barata e com benefício demonstrado na prevenção de fraturas e quedas. É feita uma abordagem da síntese, metabolismo e modo de ação da vitamina D. Faz-se uma revisão sumária da fisiopatologia da vitamina D na pele -a influência da pigmentação cutânea e do uso de fotoproteção na sua síntese, e a sua relação com as dermatoses mais frequentes. PALAVRAS-CHAVE -Neoplasias da Pele; Défice em Vitamina D; Radiação Ultravioleta; Neoplasias da Pele; Vitamina D. Vitamin D -Current Perspectives ABSTRACT -The main biological effect of vitamin D is to promote bone mineralization and regulate calcium-phosphorus metabolism, but its extra-skeletal biological function has also been extensively studied. Vitamin D deficit has been associated with an increased risk for various diseases, including autoimmune, neoplastic, cardiovascular and neurological disorders. However, areas of controversy remain: a direct cause-effect relationship between vitamin D deficiency and non-skeletal pathology and the benefit of vitamin D supplementation with this goal still has to be confirmed. In individuals at risk for vitamin D deficiency vitamin D supplementation is safe, inexpensive and with demonstrated benefit in preventing fractures and falls. The authors present an overview of the synthesis, metabolism and action of vitamin D and perform a brief review of the pathophysiology of vitamin D in the skin, namely its influence on skin pigmentation and the effect of photoprotection on vitamin D synthesis and its relationship with skin diseases. KEY-WORDS -Skin Neoplasms; Ultraviolet Rays; Vitamin D; Vitamin D Deficiency. INTRODUÇÃOA vitamina D tem como efeito biológico principal a promoção da mineralização óssea e a regulação da homeostasia do metabolismo cálcio-fósforo. A vitamina D atua como uma hormona regulando a expressão de mais de 200 genes em diferentes tipos de células com os recetores específicos. A sua função biológica extra-esqueleto tem sido amplamente estudada e o seu défice associado a risco aumentado para diversas patologias, nomeadamente autoimunes, neoplási-cas, cardiovasculares e neurológicas, entre outras. No entanto, esta mantém-se uma área de controvérsia e está por demonstrar a relação causa efeito entre deficiência de vitamina D e patologia não esquelética, e o benefício da suplementação com esse objetivo. BIOQUÍMICA E METABOLISMOAs vitaminas são um grupo de nutrientes orgânicos, requeridos e...

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Topical vitamin D analogues alone or in association with topical steroids for psoriasis: a systematic review

Cited by 47 publications

References 60 publications

Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO‐ABLE study

Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO‐ABLE study

Considerations for Care: Management of Asthma in the Child with Sickle Cell Disease

Vitamina D – Perspetivas Atuais

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