Topical vitamin C in aging

Colven, Roy; Pinnell, Sheldon R.

doi:10.1016/0738-081x(95)00158-c

Cited by 112 publications

(84 citation statements)

References 33 publications

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“…4,5,7,8,14,15 Ascorbate has many of the ideal properties of a free radical scavenger: excellent availability in tissues as well as adequate supply; compartmentalization in tissues; recyclability; versatility (interaction with superoxide, hydroxyl free radicals, and singlet oxygen); and tolerable toxic effects (megadoses of ascorbic acid 100 to 200 times the recommended daily allowance are generally well tolerated). 4 Additionally, ascorbate can regenerate ␣-tocopherol (the most active form of vitamin E) from the tocopherol radical, thus decreasing the vitamin E radical by means of a recycling mechanism. [36][37][38] Other areas of ongoing research have investigated the anti-inflammatory and wound-healing effects of ascorbic acid as well as its photopreventive effects against cutaneous malignancy.…”

Section: Commentmentioning

confidence: 99%

“…It seems to influence production of collagen by posttranslational and transcriptional mechanisms. 4 This is thought to occur as a result of ascorbate directly stimulating collagen synthesis, directly and specifically activating collagen gene regulation both by increasing the transcription rate and stabilizing procollagen messenger RNA, thus genetically signaling collagen synthesis. [5][6][7][8][9] Another mechanism is initiation of lipid peroxidation, which leads to an increase in a by-product, malondialdehyde, which somehow stimulates collagen gene expression.…”

mentioning

confidence: 99%

“…Without ingestion, ascorbic acid would be mostly depleted after 3 weeks. The minimum daily requirement for ascorbic acid is 200 mg. 16 Unfortunately, UV light exposure depletes up to two thirds of cutaneous ascorbic acid stores, 4 and oral ingestion is ineffective in achieving adequate cutaneous replenishment. Cutaneous levels not obtainable by ingestion, however, can be reached with topical application.…”

mentioning

confidence: 99%

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Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Traikovich

1999

Arch Otolaryngol Head Neck Surg

142

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Objective: To determine the efficacy of topical ascorbic acid application in treating mild to moderate photodamage of facial skin using an objective, computerassisted image analysis of skin surface topography and subjective clinical, photographic, and patient selfappraisal questionnaires.Design: A 3-month, randomized, double-blind, vehiclecontrolled study.Setting: Facial plastic surgery private practice.Patients: Nineteen evaluable volunteer sample patients aged between 36 and 72 years with Fitzpatrick skin types I, II, and III who were in good physical and mental health with mild to moderately photodamaged facial skin were considered for analysis.Intervention: Coded, unmarked medications were randomly assigned to the left and right sides of each subject's face, one containing the active agent, topical ascorbic acid (Cellex-C high-potency serum; Cellex-C International, Toronto, Ontario), the other, the vehicle serum (Cellex-C International). Three drops (0.5 mL) of each formulation were applied daily to the randomly assigned hemifaces over the 3-month study period. Treatment assignments were not disclosed to subjects, clinicians, or personnel involved in analyzing skin replicas. Main Outcome Measures:Specific clinical parameters were evaluated and graded on a 0-to 9-point scale (0, none; 1-3, mild; 4-6, moderate; and 7-9, severe). Reference photographs were used to standardize grading criteria. Overall investigator scores were compared with baseline and graded as excellent (much improved), good (improved), fair (slightly improved), no change, or worse. Patient self-appraisal questionnaires rated the degree of improvement (much improved, improved, slightly improved, no change, or worse) and reported adverse effects (burning, stinging, redness, peeling, dryness, discoloration, itching, and rash). Standard photographs were taken at baseline, including anteroposterior and left and right oblique views to facilitate subsequent clinical evaluations, and at the end of therapy for comparison. Optical profilometry analysis was performed on the skin surface replicas of the lateral canthal (crow's feet) region, comparing baseline to end-of-study specimens. Using this computer-based system, the resulting image was digitally analyzed, and numeric values were assigned to reflect surface features. The parameters obtained included R z , R a , and shadows. These values provided objective data that document pretreatment and posttreatment texture changes proportional to the degree of wrinkling, roughness, and other surface irregularities.Results: Optical profilometry image analysis demonstrated a statistically significant 73.7% improvement in the R a and shadows north-south facial axis values with active treatment greater than vehicle control, as well as a trend for improvement in the R z north-south facial axis parameter, showing a 68.4% greater improvement of active treatment vs vehicle control. Clinical assessment demonstrated significant improvement with active treatment greater than control for fine wrinkling, tactile roughnes...

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Section: Commentmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Traikovich

1999

Arch Otolaryngol Head Neck Surg

142

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“…Beside antioxidant enzymes, the antioxidant system of insects is also composed of non-enzymatic components like glutathione, ascorbic acid, vitamin E, uric acid and thioredoxin (Summers and Felton 1993;Krishnan et al 2009). Lowmolecular-weight antioxidants react with ROS in a less specific manner than enzymes and are therefore more universal and can interchangeably play a protective function (Colven and Pinnell 1996).…”

Section: Introductionmentioning

confidence: 99%

Total antioxidant capacity of honeybee haemolymph in relation to age and exposure to pesticide, and comparison to antioxidant capacity of seminal plasma

et al. 2015

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-Oxidative stress is defined as a disturbance in the balance between the production of reactive oxygen species and antioxidant defences. We measured total antioxidant capacity (TAC) in honeybee haemolymph and seminal plasma and analysed TAC of haemolymph in relation to age and exposure to pesticide. TAC of haemolymph increased with age of bees (1.18 vs 1.97 mM of (±)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) for 1-and 30-day-old bees, respectively, P ≤0.05). Exposure to imidacloprid (IMD) affected TAC of haemolymph of 1-day-old but not 30-day-old honeybees. TAC in haemolymph of 1-day-old bees was lower in treatments with the addition of 5 and 200 ppb IMD (1.57-1.46 mM of Trolox in treated bees compared with 2.37 mM of Trolox in controls; P ≤0.05). In conclusion, antioxidant protection of honeybees seems to be related to age and may be disturbed by exposure to IMD. Older bees with higher antioxidant protection seem to be less susceptible to IMD toxicity. The toxic effect of pesticide seems to be particularly dangerous in early life stages of honeybees.Apis mellifera / total antioxidant capacity / haemolymph / ageing / pesticide

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“…AA is related to the prevention or delay of certain organ disorders, including reducing the incidence of agerelated cataracts [2], ameliorating atherosclerosis (early stage) [3], and decreasing the risk of diabetes mellitus [4]. AA plays some essential roles in the human body: (1) protecting skin against UV damage; (2) preventing hyperpigmentation of the skin; (3) improving skin inflammation and reducing photocarcinogenesis; (4) increasing collagen fiber [5,6]; (5) reducing oxidative stress [5,7]; and (6) immuno-modulating effects.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C and Skin

Sugiura¹,

Sugiura²

2018

J Clin Exp Dermatol Res

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Vitamin C (VC) is one of nine water-soluble vitamins. VC is known as ascorbic acid (AA), which is a reduced form of VC. AA plays some essential roles in the human body: (1) protecting skin against UV damage; (2) preventing hyperpigmentation of the skin; (3) improving skin inflammation and reducing photocarcinogenesis; (4) increasing collagen fiber; (5) reducing oxidative stress; and (6) immuno-modulating effects. AA deficiency affects collagen and vessels structure, wound healing and hemostasis, and scurvy. VC and AA are essential for life. We hope development of new medicines using VC or AA because of few adverse side effects of VC and AA.

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Topical vitamin C in aging

Cited by 112 publications

References 33 publications

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Total antioxidant capacity of honeybee haemolymph in relation to age and exposure to pesticide, and comparison to antioxidant capacity of seminal plasma

Vitamin C and Skin

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