Topical vasoactive cream in the treatment of erectile failure: a prospective, randomized placebo‐controlled trial*

Roux, Le; Naude,

doi:10.1046/j.1464-410x.1999.00025.x

Cited by 3 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To facilitate erections, a variety of vasoactive substances have been formulated as creme or gel for local external application to the penis: nitro-glycerin [5,7,14,26,27], prostaglandin E1 [17,22], minoxidil [5], papaverine [18], co-dergocrine mesylate [11], or a mixture of aminophylline, isosorbide dinitrate and co-dergocrine mesylate [12,20].…”

Section: Discussionmentioning

confidence: 99%

Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction

Schultheiss¹,

Hiltl²,

Meschi³

et al. 2000

World J Urol

View full text Add to dashboard Cite

Androgens influence important central and peripheral mechanisms of the erectile system. The relevance of a moderate decrease of serum testosterone level for erectile dysfunction (ED) has not been clarified so far. The aim of our study was to offer an easy transcutaneous method of androgen application. A previous study on the pharmacokinetic profile of the testosterone gel applied, showed marked elevation of the serum levels of testosterone. In our study, 46 hypogonadal patients with ED and total lack of vaginal penetration applied testosterone gel (4 mg/day; supplied by Azupharma, Germany) to the penile skin twice a day over 6-8 weeks, after a run-in period with placebo gel of 2 weeks. All patients showed decreased testosterone serum levels (<3 ng/ml) in at least two morning samples over a period of 3 weeks before treatment. Psychogenic etiology was excluded by a sexual psychologist. Patient age was 37-69 years (mean 53.5). Three patients (6.5%) responded to placebo in the run-in phase and were withdrawn from further treatment. Fifteen patients (32.6%) showed improved erection, allowing penetration and sexual intercourse. Twenty-eight patients (60.9%) did not respond to therapy. Local genital skin irritation was not observed. Elevation of peripheral testosterone was not correlated to a positive therapy response. A success-rate of 32.6% in this group of patients after exclusion of psychogenic patients and placebo-responders seems to justify further investigations. A medication period of 6-8 weeks is most probably too short to induce imaginable regenerative effects of testosterone on the erectile system. We therefore suggest that future double-blind and placebo-controlled studies should be designed for a minimum of 3 months. Testosterone gel may be a cost effective form of androgen administration.

show abstract

Section: Discussionmentioning

confidence: 99%

Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction

Schultheiss¹,

Hiltl²,

Meschi³

et al. 2000

World J Urol

View full text Add to dashboard Cite

show abstract

“…Whereas the results with most of these have been disappointing, one study using the triple cream reported a 60% improvement rate (Gomaa et al, 1996). A recent study (Le Roux & Naude, 1999) was unable to reproduce the successful results reported earlier and they found no difference between the active cream and the placebo cream.…”

Section: Topical Creamsmentioning

confidence: 76%

Sexual dysfunction in old age

Phanjoo¹

2000

Adv. psychiatr. treat

View full text Add to dashboard Cite

The sexual behaviour of older people is more often the target of jocularity or ridicule than the subject of serious scientific research. As a consequence, relatively little is known about the sexual behaviour of the over-65s and such information as is available shows a polarisation according to gender, male sexual behaviour and dysfunction being viewed very much in the light of physical problems, whereas women's sexual behaviour revolves around attitudes towards sexuality and the psychological effects of ageing. This review will address the biological changes associated with ageing, the psychological and social concomitants, the prevalence of sexual dysfunction, its aetiological factors, and the management of common sexual problems including those found in an institutional setting. Biological changesMasters and Johnson described the physiology of coitus as having four components. Excitement, plateau, orgasm and resolution, all of which show age related changes. As ageing increases, desire may not always result in sexual excitement. The triggers for sexual excitement become more specifically sexual and may require intimate body contact and manual stimulation. The intensity of sexual fantasies decreases and it may take a man longer to achieve an erection and following ejaculation more time before an erection is possible. The physiological changes are listed in Box 1. In addition, older men experience anatomical changes, including thinning of the pubic hair, laxity of scrotal tissue, atrophy of the perineal muscles, loss of collagen tissue and occasionally weight gain. The phase of ejaculation undergoes changes which result in a decline in the intensity of orgasm and in the propulsive force of ejaculation. The volume of the ejaculate may be reduced by 50%. Sex drive and performance vary widely between individuals of the same group and the maintenance of sexual activity depends on factors such as regular sexual activity, the presence of a willing sexual partner, the absence of a major physical illness and the integrity of the relationship.Age-related changes in women (see Box 2) include thinning of the pubic hair, shrinkage of the labia, thinning of the vaginal mucosa and laxity of the perineal muscle. The thinning of the vaginal mucosa and the reduced lubrication may lead to dyspareunia and bleeding during intercourse. Orgasmic contractions may become painful.The ageing male experiences a reduction in the activity of the cells of Leydig with an associated drop in testosterone of 0.4-0.8% per year after the age of 50. Interested readers are referred to a Box 1. Physiological changes in ageing men Sexual organ atrophy Diminished testosterone level Delay in attaining erectionErection of poor quality Longer delay in achieving and maintaining a full penile erection Decline in intensity of orgasm Decreased hormone levels are associated with reduced desire

show abstract

Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment

2001

View full text Add to dashboard Cite

This review is designed to help the reproductive endocrinologist integrate his or her professional activity with those of other disciplines including urology, radiology, neurology, and psychology in order to successfully manage all of the inseparable aspects of male sexual and reproductive functioning. Significant advances in the field of male sexual physiology and pathophysiology and new methods of investigation and treatment of male sexual disorders are outlined. The review synthesizes available data on the following: norms of sexual organs, aging and sexuality, role of central and peripheral neurochemicals in each stage of the sexual cycle, role of corporeal smooth muscles in the hemodynamic control of erection and detumescence, influence of psychological factors, drugs, and disease on all aspects of sexual functioning, and use of nocturnal penile tumescence monitoring, imaging investigations, and neurophysiologic studies in the diagnostic workup of males with sexual dysfunction. Clinical algorithms are presented where appropriate. Extensive discussions on newly developed strategies in psychological and behavioral counseling, drug therapy, tissue engineering, nonsurgical devices, and surgical treatments for all forms of sexual disorders are also provided. Lastly, the effect of sexual dysfunction and its treatment on quality of life in affected men is addressed, along with recommendations for future research endeavors.

show abstract

Topical vasoactive cream in the treatment of erectile failure: a prospective, randomized placebo‐controlled trial*

Cited by 3 publications

References 4 publications

Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction

Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction

Sexual dysfunction in old age

Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment

Contact Info

Product

Resources

About