Topical Vancomycin Reduces Surgical-Site Infections After Craniotomy: A Prospective, Controlled Study

Mallela, Arka N.; Abdullah, Kalil G.; Brandon, Cameron; Richardson, Andrew G.; Lucas, Timothy H.

doi:10.1093/neuros/nyx559

Cited by 31 publications

(30 citation statements)

References 36 publications

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“…11 Of the 75 patients in the control group, Abdullah et al reported five SSIs and in the treatment group, they had only one infected case out of 75 patients. 14 Our findings are consistent with their findings as we had seven SSIs out of the 90 patients in the control group and no SSI in the 86 patients in the treatment group.…”

Section: Discussionsupporting

confidence: 92%

“…These findings are consistent with the findings of Abdullah et al, Mallela et al and Ravikumar et al, where they could not find any statistically significant association between gender and SSIs. 11,12,14 The rate of surgical site infections (SSIs) in different age groups was 3.17% (2 out of 63) in the age group 50-59 years, 16% (4 out of 25) in 60 -69 years and 100% (1 out of 1) in the 70 -79 years. It was highest 16% in the age groups 60 -6 % (4 out of 25 patients).Out of the seven infected cases 2 (1.13%) were identified on 3 rd post-operative day, 4 cases on the 5 th post-operative day and 1 on the 7 th postoperative day (p > 0.05).…”

Section: Discussionmentioning

confidence: 99%

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Prophylaxis of Surgical Site Infection in Cranial Surgery with Vancomycin Powder Application into Wound

Rehman¹,

Khan

Abbas

et al. 2019

Pak J Neurol Surg

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Objective: To see the effect of application of Vancomycin powder directly into the subgaleal space in reducing the postoperative surgical site infections.Materials and Methods: All the patients who underwent consecutive elective craniotomies from April 2017 to May 2018 Dept of Neurosurgery, szabmu, PIMS, Islamabad. The control group received the standard routine prophylaxis according to the hospital protocols, whereas the treatment group, in addition to the standard prophylaxis, received Vancomycin powder in the surgical wound in addition to the standard routine prophylaxis. Results: 182 patients were enrolled in the study, 91 allocated to each the control and treatment group (Vancomycin). Six patients were lost to follow up. There were 90 patients in the control group and 86 patients in the treatment (Vancomycin) group. Both the groups were almost statistically similar. In the control group, 34.09% (n = 60) were male and 17.04% (n = 30) were female. In the treatment group, 29.54% (n = 52) were male and 19.31% (n = 34) were female. The overall rate of surgical site infection (SSI) was 3.97% (7 out of 176 cases). A statistically significant difference found in infection rate between the treatment group, 0% (0 out of 86 cases) and the control group, 7.77% (7 out of 90 cases) with the p value of 0.002. Conclusions: The use of topical Vancomycin powder in surgical wounds may significantly reduce the incidence of infection in patients undergoing elective craniotomies. It is a promising means of preventing devastating and harmful postoperative wound infections.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Prophylaxis of Surgical Site Infection in Cranial Surgery with Vancomycin Powder Application into Wound

Rehman¹,

Khan

Abbas

et al. 2019

Pak J Neurol Surg

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“…surgery; similar to the orthopaedic studies, these investigations were retrospective and noncontrolled. Among patients who underwent craniotomy, vancomycin powder use was associated with lower infection risk 5,6 , while there was no association between vancomycin powder use and infection risk in cranioplasty 7 or sternal wound infection 8 .…”

Section: Antimicrobial Prophylaxis Locally Applied Vancomycin Powdermentioning

confidence: 95%

What’s New in Musculoskeletal Infection: Update on Biofilms

Nana

Nelson

McLaren

et al. 2016

The Journal of Bone and Joint Surgery

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“…67 One study found a reduction from 6 to 0.49% in a prospectively followed cohort of 355 patients. 68…”

Section: Craniotomy Infectionsmentioning

confidence: 99%

Neurosurgical Infections

2019

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Patients in the neurointensive care unit often undergo life-saving neurosurgical interventions that can be associated with serious complications. Infection is a common and sometimes fatal complication of such procedures. Infection may occur not only in the setting of major cranial and spinal surgery, but also with common minor procedures that utilize neurosurgical devices, such as placement of external ventricular drains, ventriculoperitoneal shunts, and deep brain stimulators. In this article, we review the epidemiology and microbiology of these infections, and discuss their general and procedure-specific risk factors and treatment options.

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Topical Vancomycin Reduces Surgical-Site Infections After Craniotomy: A Prospective, Controlled Study

Abstract: Topical vancomycin is a safe, effective, and cost-saving measure to prevent SSIs following craniotomy. These results have broad implications for standard of care in craniotomy.

Cited by 31 publications

References 36 publications

Prophylaxis of Surgical Site Infection in Cranial Surgery with Vancomycin Powder Application into Wound

Prophylaxis of Surgical Site Infection in Cranial Surgery with Vancomycin Powder Application into Wound

What’s New in Musculoskeletal Infection: Update on Biofilms

Neurosurgical Infections

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