Topical use of corticosteroids for the relief of pain sensitivity of dentine and pulp

Fry, Arthur E.; Watkins, Robert F.; Phatak, Nilkanth M.

doi:10.1016/0030-4220(60)90491-6

Cited by 36 publications

(8 citation statements)

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“…The anti‐inflammatory properties of glucocorticoids were first appreciated and utilized as an adjunct to endodontic therapy almost half a century ago (39–41). Glucocorticoids have been used as a pulp‐capping agent (42), as an intracanal medicament either alone or in combination with antibiotics/antihistamines (13, 39, 40, 43, 44), and systemically (3, 4, 9, 14, 41, 45–50) as a means to decrease pain and inflammation in endodontic patients. The following section will critically evaluate this research and then make recommendations for the use of glucocorticoids in endodontics; these recommendations will include, indications, contraindications, case selection, agent, dosage, and route of administration.…”

Section: Pharmacokinetics and Relative Potencies Of Corticosteroidsmentioning

confidence: 99%

Consideration of steroids for endodontic pain

Marshall¹

2002

Endodontic Topics

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Up to 80% of endodontic patients who report with preoperative pain continue to experience some level of pain following the endodontic procedure. Since endodontic pain is often associated with chronic inflammation, the presence of bacterial by‐products, influx of primed immune cells and activation of the cytokine network and other inflammatory mediators, pain may be reduced by administration of glucocorticoid steroids. This review will include the pharmacology, pharmacodynamics and purported mechanisms of actions of steroids as well as their indications for endodontics, contraindications, dosages and side‐effects.

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Section: Pharmacokinetics and Relative Potencies Of Corticosteroidsmentioning

confidence: 99%

Consideration of steroids for endodontic pain

Marshall¹

2002

Endodontic Topics

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“…Given that this tissue is closely related to the dentin, forming the dentin-pulp complex, the pulp can be affected by aggressions to the dentin 2 , 12 , 20 . Moreover, due to the intimate relation between these tissues and the dentinal permeability, molecules of medications, such as corticosteroids, applied on the exposed dentin, diffuse through the dentinal tubules, with the potential to provide a therapeutic effect, alleviating the painful symptom 6 , 15 .…”

Section: Introductionmentioning

confidence: 99%

“…That is why the application of an antiinflammatory agent inhibits edema, vasodilatation and the chemotactic effects on leukocytes. Moreover, corticosteroids will act on histamine, heparin, and bradicinin, which are important chemical mediators in the initial phases of acute inflammation 6 , 16 . The activation of the cinin system results in the release of bradicinin norpeptide.…”

Section: Introductionmentioning

confidence: 99%

Effect of betamethasone on the pulp after topical application to the dentin of rat teeth: vascular aspects of the inflammation

et al. 2009

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Objective:This study investigated the pulpal effect of topically applied betamethasone to the dentin of rat molars in the vascular phase of inflammation.Material and Methods:Deep cavities were prepared on the occlusal face of the maxillary right and left 1st molars with non-refrigerated inverted-cone steel burs at low speed. Three groups were formed: Group I was composed of right 1st molars; Group II was composed of left 1st molars that received the application of a drop of betamethasone on dentin surface for 5 min; and Group III (control) was composed of right 2nd molars that received no cavity preparation or betamethasone application. Changes in the vascular characteristics of the pulp tissue were checked by calculating the pulp vascular area in relation to its total area and the number of blood vessels per unit area. Data were subjected to ANOVA and Tukey's test (α=0.05).Results:Group I presented a significantly larger number of vessels (p<0.05) than Group II. Regarding the vascular/total area ratio (%), Group I presented statistically significantly higher values (p=0.01) than Groups II and III.Conclusion:Betamethasone applied on the dentin of rat teeth proved to reduce the vascular phase of pulp inflammation regarding vessel diameter and number of blood vessels.

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“…This combination, with prednisolone in 1% concentration, has been used as a pulp-capping agent to reduce thermal sensitivity in dental restorations since about 1960 (4,5 ) . Mosteller (5, 6) has expressed doubt as to the stability of the combination beyond a period of 90 days.…”

Section: Resultsmentioning

confidence: 99%

Stability of Prednisolone in an Organic Vehicle

Bowles

1968

Journal of Pharmaceutical Sciences

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Topical use of corticosteroids for the relief of pain sensitivity of dentine and pulp

Cited by 36 publications

References 1 publication

Consideration of steroids for endodontic pain

Consideration of steroids for endodontic pain

Effect of betamethasone on the pulp after topical application to the dentin of rat teeth: vascular aspects of the inflammation

Stability of Prednisolone in an Organic Vehicle

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