Topical tretinoin or adapalene in acne vulgaris: an overview

Jain, Som Akshay

doi:10.1080/09546630410033006

Cited by 37 publications

(26 citation statements)

References 37 publications

(29 reference statements)

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“…Retinoic acid is currently used for treatment of severe acne, psoriasis, and acute promyelocytic leukemia (32)(33)(34)(35). Treatment is carried out for long periods of time and by and large well tolerated.…”

Section: Discussionmentioning

confidence: 99%

Potential Role for Retinoic Acid in Patients with Cushing's Disease

Giraldi

Ambrogio

Andrioli³

et al. 2012

The Journal of Clinical Endocrinology & Metabolism

103

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Context: Cushing's disease, i.e. cortisol excess due to an ACTH-secreting pituitary adenoma, is a rare disorder with considerable morbidity and mortality but no satisfactory medical treatment as yet. Experimental data have recently shown that retinoic acid restrains ACTH secretion by tumoral corticotropes.Objective: Our objective was to evaluate the efficacy and safety profile of retinoic acid treatment in patients with Cushing's disease.Design: This is a prospective, multicenter study. Seven patients with Cushing's disease (three men, four postmenopausal women) were started on 10 mg retinoic acid daily and dosage increased up to 80 mg daily for 6 -12 months. ACTH, urinary free cortisol (UFC), and serum cortisol as well as clinical features of hypercortisolism and possible side effects of retinoic acid were evaluated at baseline, during retinoic acid administration, and after drug withdrawal.Results: A marked decrease in UFC levels was observed in five patients; mean UFC levels on retinoic acid were 22-73% of baseline values and normalization in UFC was achieved in three patients. Plasma ACTH decreased in the first month of treatment and then returned to pretreatment levels in responsive patients whereas no clear-cut pattern could be detected for serum cortisol. Blood pressure, glycemia, and signs of hypercortisolism, e.g. body weight and facial plethora, were ameliorated to a variable extent on treatment. Patients reported only mild adverse effects, e.g. xerophthalmia and arthralgias. Abbreviations: COUP-TF1, Chicken ovoalbumin upstream promoter transcription factor 1; PPAR␥, peroxisome proliferator-activated receptor ␥; UFC, urinary free cortisol; WBC, white blood cells.

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Section: Discussionmentioning

confidence: 99%

Potential Role for Retinoic Acid in Patients with Cushing's Disease

Giraldi

Ambrogio

Andrioli³

et al. 2012

The Journal of Clinical Endocrinology & Metabolism

103

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“…There are 4 published randomized, double-blinded, controlled trials investigating the therapeutic utility of cyclosporine for patients with CU/angioedema who had failed second-generation antihistamines [145-148]. Although the results of these studies show favorable effects, the side effects of this agent may outweigh its benefits.…”

Section: Treatmentmentioning

confidence: 99%

Diagnosis and Treatment of Urticaria and Angioedema: A Worldwide Perspective

Sánchez‐Borges

Asero

Ansotegui³

et al. 2012

World Allergy Organization Journal

180

111

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Urticaria and angioedema are common clinical conditions representing a major concern for physicians and patients alike. The World Allergy Organization (WAO), recognizing the importance of these diseases, has contributed to previous guidelines for the diagnosis and management of urticaria. The Scientific and Clinical Issues Council of WAO proposed the development of this global Position Paper to further enhance the clinical management of these disorders through the participation of renowned experts from all WAO regions of the world. Sections on definition and classification, prevalence, etiology and pathogenesis, diagnosis, treatment, and prognosis are based on the best scientific evidence presently available. Additional sections devoted to urticaria and angioedema in children and pregnant women, quality of life and patient-reported outcomes, and physical urticarias have been incorporated into this document. It is expected that this article will supplement recent international guidelines with the contribution of an expert panel designated by the WAO, increasing awareness of the importance of urticaria and angioedema in medical practice and will become a useful source of information for optimum patient management worldwide.

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“…Retinoids are teratogenic and their use is contra-indicated during pregnancy. Nevertheless, congenital malformations induced by topical application of retinoids have never been demonstrated in epidemiological studies (18,19). With regard to teratogenic effects after application of external retinoids, one has to realize that the intake of retinoids from food has a considerably higher effect on retinoid serum levels than tretinoin application on a restricted area such as the face (20).…”

Section: Topical Therapiesmentioning

confidence: 99%

Current and future treatment options for acne

Kerkhof

Kleinpenning

Jong

et al. 2006

Journal of Dermatological Treatment

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Acne is a frequent skin disease with abnormalities in the process of keratinization, sebaceous gland functioning and inflammation. In this review, our understanding of the pathogenesis of acne has been updated. An overview of efficacy and side effects of available anti-acne treatments is presented. Based on the present overview a recommendation for the treatment of various manifestations of acne is provided, also reconciling beneficial combinations of treatments. It is attractive to speculate that the increased insight into the pathogenesis of acne will create new treatment options. Challenging new options comprise blue light, photodynamic therapy, retinoic acid metabolism blocking agents and inhibitors of Th-1 cytokines.

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Topical tretinoin or adapalene in acne vulgaris: an overview

Abstract: The preliminary results of our study suggest that CsA is clinically effective for chronic urticaria. The prolonged use of this therapy for more than 1 month provides little benefit in the clinical improvement.

Cited by 37 publications

References 37 publications

Potential Role for Retinoic Acid in Patients with Cushing's Disease

Potential Role for Retinoic Acid in Patients with Cushing's Disease

Diagnosis and Treatment of Urticaria and Angioedema: A Worldwide Perspective

Current and future treatment options for acne

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