Topical treatment of psoriasis vulgaris

Ramic, Lejla; Sator, Paul

doi:10.1111/ddg.15042

Cited by 5 publications

(3 citation statements)

References 66 publications

(156 reference statements)

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“…On the other hand, one role of vitamin D at the skin level is the inhibition of keratinocyte proliferation [ 12 ], knowing that skin lesions in PV are partially due to keratinocyte hyperproliferation and abnormal differentiation [ 13 ]. Vitamin D deficiency has been associated with the pathogenesis of PV [ 14 ] and topical treatment with vitamin D analogs has been extensively used in PV [ 15 ]. In addition, vitamin E, a potent antioxidant, was found to be deficient in patients with PV compared to healthy subjects [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Low Vitamin K Status in Patients with Psoriasis Vulgaris: A Pilot Study

Gheorghe,

Ilyés,

Filip

et al. 2024

Biomedicines

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Psoriasis vulgaris (PV) is a disease characterized by skin manifestations and systemic inflammation. There are no published studies to date on vitamin K status assessed by extrahepatic vitamin K-dependent proteins [e.g., osteocalcin (OC) and matrix Gla protein (MGP)] in patients with PV, even if vitamin K was found to promote wound contraction and decrease the healing time of the skin. Metabolic syndrome (MS), a comorbidity of PV, was found to influence vitamin K status, and vitamin D was found to be involved in the pathogenesis of PV. Therefore, our aim was to assess the status of vitamins K and D in subjects with PV. We enrolled 44 patients with PV and 44 age- and sex-matched subjects as a control group (CG), of which individuals with MS were designated the CG with MS subgroup. Furthermore, the PV patients were stratified into two subgroups: those with MS (n = 20) and those without MS (n = 24). In addition to the quantification of vitamin D and MGP in all subjects, the uncarboxylated OC/carboxylated OC (ucOC/cOC) ratio was also assessed as an inversely proportional marker of vitamin K status. We found an increased ucOC/cOC ratio in the PV group compared to CG but also a greater ucOC/cOC ratio in the PV with MS subgroup than in the CG with MS subgroup. MGP was decreased in the PV with MS subgroup compared to CG with MS subgroup. There was no difference in the vitamin D concentration between the groups. This is the first study to report decreased vitamin K status in patients with PV, independent of the presence of MS.

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Section: Introductionmentioning

confidence: 99%

Low Vitamin K Status in Patients with Psoriasis Vulgaris: A Pilot Study

Gheorghe,

Ilyés,

Filip

et al. 2024

Biomedicines

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“…The treatment of psoriasis depends on various factors, such as the severity of the disease, its location, and any accompanying conditions. Topical therapy, involving the use of corticosteroids, vitamin D analogs (such as calcipotriene, calcitriol and tacalcitol), retinoids (such as tazarotene and tazarotene), anthralin and topical immunomodulators as calcineurin inhibitors, is the preferred treatment for patients with mild psoriasis [ 7 ]. Psoriasis is a common skin condition that can cause dry and irritated skin.…”

Section: Introductionmentioning

confidence: 99%

Excimer Laser System: The Revolutionary Way to Treat Psoriasis

Alyoussef

2023

Cureus

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Psoriasis is a chronic, autoinflammatory skin disease that affects approximately 100 million people worldwide. It is a systemic disease characterized by scaly, red patches on the skin and can also affect the joints. Psoriasis can significantly affect a person's physical and mental health. The prevalence rate of psoriasis may vary depending on the specific population studied and the diagnostic criteria used. Phototherapy is a safe and effective treatment for psoriasis that involves exposing the affected skin to specific wavelengths of light. It can be used alone or with other treatments for severe psoriasis. However, clinicians must choose the right light source for each type of psoriasis and monitor the patient closely during treatment to avoid adverse events. The 308 nm excimer laser is a widely used device in dermatology for treating several skin conditions, including psoriasis. Although the excimer laser can treat various dermatologic diseases, this study will focus only on its effectiveness in treating psoriasis. This study will review the use of an excimer laser, its protocol, and its side effects.

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“…The choice of treatment for psoriasis depends on several factors, including location, the severity of the disease, and whether it is accompanied by other diseases [ 5 ]. Topical therapy involving corticosteroids, vitamin D analogues, tapinarof, and calcineurin inhibitors is the gold standard for patients with mild psoriasis [ 6 ]. Oral systemic therapies are the conventional treatment options for patients with moderate to severe psoriasis, with oral systemic agents such as methotrexate, acitretin, ciclosporin, dimethyl fumarate, apremilast, and tofacitinib [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Route for Investigating Psoriasis: From the Perspective of the Pathological Mechanisms and Therapeutic Strategies of Cancer

Wu,

Ma,

Wang

et al. 2023

IJMS

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Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully elucidated. The core pathological process of psoriasis is epidermal thickening caused by the excessive proliferation of epidermal keratinocytes, which is similar to the key feature of cancer; the malignant proliferation of cancer cells causes tumor enlargement, suggesting that there is a certain degree of commonality between psoriasis and cancer. This article reviews the pathological mechanisms that are common to psoriasis and cancer, including the interaction between cell proliferation and an abnormal immune microenvironment, metabolic reprogramming, and epigenetic reprogramming. In addition, there are common therapeutic agents and drug targets between psoriasis and cancer. Thus, psoriasis and cancer share a common pathological mechanisms–drug targets–therapeutic agents framework. On this basis, it is proposed that investigating psoriasis from a cancer perspective is beneficial to enriching the research strategies related to psoriasis.

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Topical treatment of psoriasis vulgaris

Cited by 5 publications

References 66 publications

Low Vitamin K Status in Patients with Psoriasis Vulgaris: A Pilot Study

Low Vitamin K Status in Patients with Psoriasis Vulgaris: A Pilot Study

Excimer Laser System: The Revolutionary Way to Treat Psoriasis

A Route for Investigating Psoriasis: From the Perspective of the Pathological Mechanisms and Therapeutic Strategies of Cancer

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