Topical treatment of multiple actinic keratoses of the face with arotinoid methyl sulfone (Ro 14-9706) cream versus tretinoin cream: A double-blind, comparative study

Misiewicz, J. J.; Sendagorta, E.; Golebiowska, Aleksandra; Lorenc, B; Czametzki, B.M.; Jabłońska, Stefania

doi:10.1016/0190-9622(91)70070-i

Cited by 42 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most previous studies of tretinoin have limited durations of follow‐up, ranging from 3 to 12 weeks 9–22 . A few studies have longer durations of follow‐up, ranging from 6 to 12 months, some present data only for certain time points (e.g.…”

Section: Discussionmentioning

confidence: 99%

Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial

Geng

Weinstock

Hall

et al. 2009

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial

Geng

Weinstock

Hall

et al. 2009

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Compared to pre-treatment numbers, the decrease was significant but there was no difference between the two drugs, although Ro 14-9706 was better tolerated. 40 Euvrard et al (1998) compared different concentrations of adapalene, revealing a significant reduction in AK number of 32% versus 21%, with concentrations of 0.3% and 0.1% respectively. 34 Only one study showed no difference in terms of retinoid use concerning reduction in AK numbers, in all the groups analyzed (0.02% tretinoin, 0.02% tretinoin combined with calcipotriol, calcipotriol and emollient).…”

Section: Studies On the Use Of Systemic And Topical Retinoids In The mentioning

confidence: 99%

Retinoids for prevention and treatment of actinic keratosis

Ianhez

Fleury

Miot

et al. 2013

An. Bras. Dermatol.

View full text Add to dashboard Cite

Actinic keratosis is a common cause of dermatological consultations and it presents a strong association with squamous cell carcinoma. Many substances are used for treatment and prevention, such as retinoids. Nevertheless, many studies on retinoids emphasize their application in treating and preventing non melanoma skin cancers. In this article, we reviewed studies about systemic and topical retinoids used with immunocompetent patients and organ transplant recipients with actinic keratosis, as primary or secondary outcomes. The majority of these papers pointed to a reduction in actinic keratosis count after treatment with retinoids. However, studies need to be better-defined in order to address the lack of a standardized dose, the absence of control groups, the low number of patients and short follow-up periods. Blind, randomized and controlled clinical trials with adequate sample sizes, specifically focused on actinic keratosis, are needed to clarify the real benefit of topical and/or oral retinoids. Comparison of efficacy and safety between oral and topical retinoids in the prevention and treatment of non-melanoma skin cancers and actinic keratosis is an essential pre requisite to establish new strategies to control these conditions.

show abstract

“…A significant and similar mean percent decrease in the number of actinic keratoses was described after 16 weeks of therapy with either compound. 61 Recently, a large multicenter study of topical tretinoin cream for facial actinic keratoses demonstrated a significant decrease of approximately 50% in the size and number of actinic keratoses after 6-15 months.62 Sun avoidance and sunscreen use alone, known to decrease the number of new and preexisting actinic k e r a t~s e s ?~ accompanied by use of the vehicle cream were also effective, although significantly less so than the same regimen including tretinoin.62…”

Section: Precancerous Conditionsmentioning

confidence: 99%

Retinoids and the Skin

Futoryan

Gilchrest

2009

Nutrition Reviews

View full text Add to dashboard Cite

Retinoids are a group of naturally occurring and synthetic compounds with vitamin A‐like biological activity. They play an important role in vision, reproduction, growth, and epithelial cell differentiation. Recent discoveries of specific retinoid cellular binding proteins and nuclear receptors have led to a better (although not complete) understanding of the complex mechanisms of retinoid action. Numerous clinical studies have demonstrated beneficial effects of retinoids on skin diseases such as acne, psoriasis, ichthyoses, keratodermas, skin cancers and their precursors, as well as a reversal of the effects of photoaging.

show abstract

Topical treatment of multiple actinic keratoses of the face with arotinoid methyl sulfone (Ro 14-9706) cream versus tretinoin cream: A double-blind, comparative study

Cited by 42 publications

References 9 publications

Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial

Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial

Retinoids for prevention and treatment of actinic keratosis

Retinoids and the Skin

Contact Info

Product

Resources

About