Topical Treatment of Cutaneous Candidiasis with 5-Fluorocytosine Compared with Nystatin

Gisslén, H; Hersle, K; Mobacken, H

doi:10.1159/000251929

Cited by 4 publications

(7 citation statements)

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“…Nystatin demonstrated clinical cure rates compared to placebo of 76% vs. 28% ( P < 0.01), mycological cure rates of 68% vs. 16% ( P < 0.01) and complete cure rates of 100% vs. 13% . Nystatin therapy was reported similar in efficacy to topical clotrimazole 1%, 5‐fluorocytosine 10%, haloprogin 1% and nystatin–triamcinolone combination therapy and to oral nystatin therapy, while it was tested inferior to mupirocin (Table ).…”

Section: Resultsmentioning

confidence: 98%

“…Overall, 41 articles investigated topical therapy for cutaneous candidiasis including 2711 patients in 35 RCTs (LE: 1B) and seven prospective blinded or open‐label trials (LE: 2B), of which one article reported two trials in the same article (LE: 1B and 2B) (Table ). In total, 17 different single‐drug and four combination therapies were investigated including clotrimazole (12 studies, LE: 1B or 2B), nystatin (ten studies, LE: 1B or 2B), miconazole (eight studies, LE: 1B), halcinonide–neomycin–amphotericin B (three studies, LE: 1B), ciclopirox (two studies, LE: 1B and 2B), haloprogin (two studies, LE: 1B), halcinonide–neomycin–nystatin (two studies, LE: 1B), naftifine (two studies, LE: 1B), sulconazole (two studies, LE: 1B), mupirocin (two studies, LE: 1B or 2B) and a number of drugs tested in a single study (Table ). In 50% of the studies, the type of Candida was specified by microscopy and/or culture and the majority recorded C. albicans , whereas three studies also found a few patients with C. parapsilosis or C. tropicalis .…”

Section: Resultsmentioning

confidence: 99%

“…Topical nystatin 100 000 U/g applied 2–4 times daily for 6–28 days was investigated in 10 studies including cutaneous candidiasis at all body regions in infants to elderly patients (LE: 1B or 2B) (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Infants and adults with Candida at all body regions had clinical cure rates of 76% vs. 37%–58% and mycological cure rates of 68% vs. 92%–100% …”

Section: Resultsmentioning

confidence: 99%

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Cutaneous candidiasis – an evidence‐based review of topical and systemic treatments to inform clinical practice

Taudorf

Jemec

Hay

et al. 2019

Acad Dermatol Venereol

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Cutaneous candidiasis is a common skin disease, and several treatments have been investigated within the last fifty years. Yet, systematic reviews are lacking, and evidence-based topical and systemic treatment strategies remain unclear. Thus, the aim of this review was to summarize efficacy and adverse effects of topical and oral therapies for cutaneous candidiasis in all age groups. Two individual researchers searched PubMed and EMBASE for 'cutaneous candidiasis' and 'cutaneous candidiasis treatment', 'intertrigo', 'diaper dermatitis' and 'cheilitis'. Searches were limited to 'English language', 'clinical trials' and 'human subjects', and prospective clinical trials published in abstracts or articles were included. In total, 149 studies were identified, of which 44 were eligible, comprising 41 studies of 19 topical therapies and four studies of three systemic therapies for cutaneous candidiasis. Topical therapies were investigated in infants, children, adolescents, adults and elderly, while studies of systemic therapies were limited to adolescents and adults. Clotrimazole, nystatin and miconazole were the most studied topical drugs and demonstrated similar efficacy with complete cure rates of 73%-100%. Single-drug therapy was as effective as combinations of antifungal, antibacterial and topical corticosteroid. Four studies investigated systemic therapy, and oral fluconazole demonstrated similar efficacy to oral ketoconazole and topical clotrimazole. Limitations to this review were mainly that heterogeneity of studies hindered meta-analyses. In conclusions, clotrimazole, nystatin and miconazole were the most studied topical drugs and demonstrated equal good efficacy and mild adverse effects similar to combinations of antifungal, antibacterial and topical corticosteroids. Oral fluconazole was as effective as topical clotrimazole and is the only commercially available evidence-based option for systemic treatment of cutaneous candidiasis.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Infants and adults with Candida at all body regions had clinical cure rates of 76% vs. 37%–58% and mycological cure rates of 68% vs. 92%–100% …”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous candidiasis – an evidence‐based review of topical and systemic treatments to inform clinical practice

Taudorf

Jemec

Hay

et al. 2019

Acad Dermatol Venereol

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show abstract

“…The applied antimycotics were categorized according to the Dutch Pharmacotherapeutic Compass: antimycotic antibiotics (amphotericine-B [36], nystatine [39,40], candidicin [37], pimaricin [30]); imidazoles (ketoconazole [27,28,31], micozanole [57], bifonazole [58], clotrimazole [20,22], econazole [20,22,43,49,51,52], thiabendazole [56], tioconazole [53,55]); triazoles (fluconazole [23]); allylamine (naftifin [45]) and other antimycotic (cyclopyroxolamine [46,54], fluorocytosin [39], dibenzthieen [38], buclosamide [41]).…”

Section: Resultsmentioning

confidence: 99%

Prevention and treatment of intertrigo in large skin folds of adults: a systematic review

Mistiaen

Halm-Walters²

2010

BMC Nurs

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BackgroundIntertrigo in the large skin folds is a common problem. There is a plethora of treatments, but a lack of evidence about their efficacy. A nursing guideline on this matter had to be updated and broadened in scope to other health care professionals.MethodsA systematic review was performed. Thirteen databases were sensitively searched, supplemented by reference tracking and forward citation searches. All types of empirical research relating to the prevention or treatment of intertrigo were included. Study selection, assessment of bias, data-extraction and analysis were done by two independent review-authors.ResultsSixty-eight studies fulfilled the inclusion criteria. Only 4 studies were RCTs and even these had a considerable risk of bias. Study populations were generally small.No studies were found about the prevention of intertrigo. The therapies concerned mostly the topical application of antimycotics, corticosteroids, antibiotics, antiseptics or a combination of these. Besides these pharmaceutical interventions, surgical breast reduction was also studied. Although most study-authors were positive, we could not draw firm conclusions about any of the pharmaceutical interventions. Even patients that received placebo intervention showed improvement. There is weak evidence that reduction mammaplasty may be helpful to treat inframammary intertrigo. All research found had considerable risk of bias, prohibiting firm conclusions.ConclusionsThere is no evidence at all about the prevention of intertrigo and there is no firm evidence about its treatment. Well designed studies are needed.

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Antifungal agents

D’Arcy

Scott

1978

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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Topical Treatment of Cutaneous Candidiasis with 5-Fluorocytosine Compared with Nystatin

Cited by 4 publications

References 0 publications

Cutaneous candidiasis – an evidence‐based review of topical and systemic treatments to inform clinical practice

Cutaneous candidiasis – an evidence‐based review of topical and systemic treatments to inform clinical practice

Prevention and treatment of intertrigo in large skin folds of adults: a systematic review

Antifungal agents

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