Topical Treatment of Burns

Mafenide Acetate Cream

“…Studies with rnafenide cream have included retrospective comparisons with regimens used prior to the introduction of topical antibacterial agents Winkley et al, 1968;Haynes et al, 1969;Moncrief, 1969;Bruck et al, 1970;Hummel et al, 1970) and comparisons with other topical agents: silver nitrate solution (Kaplan and Berggren, 1968;Winkley et al, 1968) ; gentamicin ointment, silver sulphadiazine ointment and silver nitrate solution (Hummel et al, 1968). Bruck et al (1970) made a retrospective analysis of 412 burned children under the age of 15 years treated from 1959 through 1968.…”

“…Winkley et al (1968) describe a comparative trial between mafenide acetate cream and 0.5 % silver nitrate solution for the control of burn wound infection. Rash occurred in 5 patients but this disappeared after cessation of the drug ; altogether 6 patients were withdrawn because of skin rash and/or pain.…”