Topical thrombin-induced IgE-mediated anaphylaxis: RAST analysis and skin test studies

Tadokoro, Kenji; Ohtoshi, Takayuki; Takafuji, Shigeru; Nakajima, Kazunori; Suzuki, Shuji; Yamamoto, Kazuhiko; Izutsu, Koji; Miyamoto, Terumasa; Muranaka, M

doi:10.1016/0091-6749(91)90156-i

Cited by 49 publications

(20 citation statements)

References 9 publications

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“…7 In addition, bovine thrombin has been shown to have potentially significant immunologic side effects. 26 Because PRP is obtained from autologous blood, it is easily accessible and safe without transmissible diseases such as HIV and hepatitis. Within PRP, the increased number of platelets delivers an increased amount of growth factors, such as PDGF, PDGFbb, TGF-b, VEGF, and EGF.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on bone regeneration of calvarial defects in rabbits

Yun

Yoo

Choi

et al. 2012

Tissue Eng Regen Med

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Bone tissue regeneration techniques include tissue engineering approaches which employ mesenchymal stem cells as an osteogenic agent for bone repair. Recent studies have demonstrated that tissue engineering scaffolds and growth factors can support cell proliferation, bone formation, and bone tissue repair in lost bone tissue. Furthermore, many studies have suggested that platelet-rich plasma (PRP) can improve bone regeneration due to the numerous growth factors that it contains. This study was performed to investigate the influence of bone marrow-derived mesenchymal stem cells (BMMSCs) and PRP on bone regeneration of calvarial defects in rabbits. Hydroxyapatite (HA) was used as a scaffold for bone regeneration. There were three groups in this experiment: 1) HA loaded with BMMSCs (HS group), 2) HA loaded with PRP (HP group), and 3) HA loaded with BMMSCs and PRP (HSP group). Two circular bony defects (6 mm in diameter) were made in rabbit calvaria using a trephine bur. BMMSCs and PRP with a HA scaffold (diameter 5.5 mm, height 3 mm) were applied to each defect. The animals were sacrificed after 2 weeks, 4 weeks and 8 weeks. The level of their ability of osteogenesis was evaluated through histological and histomorphometric analyses. High-quality bone regeneration was observed in the HSP group. The percentage of new bone area around the scaffolds was higher in the HSP group than it was in the other groups (HS and HP group), especially at 8 weeks (HS, 72.5±15 %; HP, 85.8±14 %; HSP, 98.8±2.5%). In addition, the level of bone maturation was higher in the HSP group than in the other groups. The results of this study show that PRP has a positive effect on bone generation. HA with a combination of BMMSCs and PRP can enhance bone regeneration. In addition, the growth factor capacity of PRP may affect the differentiation of BMMSCs and promote bone formation.

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Section: Discussionmentioning

confidence: 99%

Synergistic effect of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on bone regeneration of calvarial defects in rabbits

Yun

Yoo

Choi

et al. 2012

Tissue Eng Regen Med

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“…Administration of bovine fibrin glue can also induce immediate reactions in the form of Immunoglobulin E (IgE)-mediated anaphylaxis against thrombin [59, 60]. If aprotinin of bovine origin is used in fibrin sealant to prevent lysis of the clot, anaphylactic reactions can develop [61, 62].…”

Section: Issues Of Immune Response To Foreign Proteins and Biomateriamentioning

confidence: 99%

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Uibo

Laidmäe

Sawyer

et al. 2009

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Polymeric scaffolds formed from synthetic or natural materials have many applications in tissue engineering and medicine, and multiple material properties need to be optimized for specific applications. Recent studies have emphasized the importance of the scaffolds’ mechanical properties to support specific cellular responses in addition to considerations of biochemical interactions, material transport, immunogenicity, and other factors that determine biocompatibility. Fibrin gels formed from purified fibrinogen and thrombin, the final two reactants in the blood coagulation cascade, have long been shown to be effective in wound healing and supporting the growth of cells in vitro and in vivo. Fibrin, even without additional growth factors or other components has potential for use in neuronal wound healing in part because of its mechanical compliance that supports the growth of neurons without activation of glial proliferation. This review summarizes issues related to the use of fibrin gels in neuronal cell contexts, with an emphasis on issues of immunogenicity, and considers the potential advantages and disadvantages of fibrin prepared from non-mammalian sources.

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“…TBT is also an allergenic substance and has caused sensit‐ivity and allergic reactions, including anaphylaxis [2–4]. Since TBT is a concentrate of bovine plasma thrombin and contains various bovine plasma proteins, the application of this heterologous protein onto broken skin or more invasively can sensitize some people and cause serious adverse reactions.…”

Section: Introductionmentioning

confidence: 99%

Anaphylaxis from topical bovine thrombin (Thrombostat®) during haemodialysis and evaluation of sensitization among a dialysis population

Wai

Tsui

Peng

et al. 2003

Clin Experimental Allergy

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Topical thrombin-induced IgE-mediated anaphylaxis: RAST analysis and skin test studies

Cited by 49 publications

References 9 publications

Synergistic effect of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on bone regeneration of calvarial defects in rabbits

Synergistic effect of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on bone regeneration of calvarial defects in rabbits

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Anaphylaxis from topical bovine thrombin (Thrombostat®) during haemodialysis and evaluation of sensitization among a dialysis population

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