Topical Tenofovir Pre-exposure Prophylaxis and Mucosal HIV-Specific Fc-Mediated Antibody Activities in Women

K, Fisher; Mabuka, Jennifer; Sivro, Aida; Ngcapu, Sinaye; Passmore, Jo‐Ann S.; Osman, Farzana; Ndlovu, Bongiwe; Karim, Quarraisha Abdool; Karim, Salim S. Abdool; Chung, Amy W.; Baxter, Cheryl; Archary, Derseree

doi:10.3389/fimmu.2020.01274

Cited by 1 publication

(1 citation statement)

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“…However, in the RV144 vaccine trial, IgG antibodies correlated with lower HIV-1 risk and were able to drive ADCC, ADCP and complement activation [ 79 , 217 ], underscoring the role of non-neutralizing effector functions in protective vaccination. In a recent study, HIV-specific antibodies demonstrated antibody-dependent neutrophil phagocytosis (ADNP) and ADCC functions in the genital tract [ 218 ]. In addition, HIV-specific ADCC directly and significantly correlated between the blood and genital compartments.…”

Section: Mucosal Immunitymentioning

confidence: 99%

Preventive HIV Vaccines-Leveraging on Lessons from the Past to Pave the Way Forward

Sobia

Archary

2021

Vaccines

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Almost four decades on, since the 1980’s, with hundreds of HIV vaccine candidates tested in both non-human primates and humans, and several HIV vaccines trials later, an efficacious HIV vaccine continues to evade us. The enormous worldwide genetic diversity of HIV, combined with HIV’s inherent recombination and high mutation rates, has hampered the development of an effective vaccine. Despite the advent of antiretrovirals as pre-exposure prophylaxis and preventative treatment, which have shown to be effective, HIV infections continue to proliferate, highlighting the great need for a vaccine. Here, we provide a brief history for the HIV vaccine field, with the most recent disappointments and advancements. We also provide an update on current passive immunity trials, testing proof of the concept of the most clinically advanced broadly neutralizing monoclonal antibodies for HIV prevention. Finally, we include mucosal immunity, the importance of vaccine-elicited immune responses and the challenges thereof in the most vulnerable environment–the female genital tract and the rectal surfaces of the gastrointestinal tract for heterosexual and men who have sex with men transmissions, respectively.

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Section: Mucosal Immunitymentioning

confidence: 99%