Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: A randomized, observer-blinded trial

Hand Eczema

“…32,33 In a small trial conducted with patients who had chronic dyshidrotic palmar eczema, the administration of tacrolimus 0.1% twice daily resulted in improvement rates of 50% or more, but the rates were not significantly different from those associated with the use of topical mometasone furoate. 34 In another small randomized trial, of 12 weeks' duration, the use of tacrolimus ointment twice daily was compared with the use of vehicle cream alone among patients previously treated with a short course of oral glucocorticoids. The use of tacrolimus was associated with greater subjective improvement (as assessed by the patient) but was associated with no clear benefit with regard to other outcomes, including the time to recurrence.…”

“…35 In practice, one option is to alternate the use of these agents with topical glucocorticoids. 8,34 Phototherapy Phototherapy is widely used for hand eczema, and in many clinics it is used as second-line treatment for patients in whom topical therapy has failed. In a 12-week trial involving 35 patients, photochemotherapy with psoralen and ultraviolet A (PUVA) was compared with treatment with ultraviolet B (UVB) alone, both in two study groups and within the same patient (comparing a treated hand with an untreated hand).…”

Update on Hand Eczema with Special Focus on the Impact of Moisturisers

“…Tacrolimus has been shown to be as effective as mometasone furoate [ 62 ] whereas pimecrolimus appears to be equivalent to a mildly potent topical steroid [ 63 ] . Adverse effects include transient stinging, fl ushing with alcohol and skin infection.…”

New and rarley used treatment options for refractory hand eczema

“…Tacrolimus wurde dabei in einer Konzentration von 0,1% über 4 Wochen 2mal täglich ange wandt. In einer randomisierten, Untersu cherverblindeten Vergleichsstudie wur de die Effektivität von Tacrolimus 0,1% im Vergleich zu einer Therapie mit Mo metasonfuorat 0,1% bei 16 Patienten mit chronisch dyshidrosiformem Hand und Fußekzem untersucht [15]. In dieser Stu die wurde gezeigt, dass die Anwendung von Tacrolimus genauso wirksam ist wie Mometasonfuorat, beide Substanzen wur den jeweils 2mal täglich über 4 Wochen lokal appliziert.…”