2015
DOI: 10.5114/pdia.2014.40962
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Topical steroid therapy in atopic dermatitis in theory and practice

Abstract: IntroductionTopical glucocorticosteroids (GCSs) are commonly used in treatment of atopic dermatitis (AD).AimTo assess the patients’ compliance with the recommended instructions of the therapy.Material and methodsThe study involved 141 adult AD patients. The clinical course of AD and its treatment with GCSs during the last year were analysed.ResultsIn the periods of exacerbation the lesions involved 10–50% of the skin surface area. Outpatient treatment in specialised dermatological and/or allergology clinics wa… Show more

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Cited by 18 publications
(16 citation statements)
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“…As a standard therapy for the treatment of AD, topical or systemic steroids and antihistamines are administered in combination with immunosuppressive agents and antibiotics (Schäkel et al, 2014). However, these long-term remedies are not effective in many AD patients due to severe side effects, such as tolerability, metabolic abnormalities, increased infection, and endocrine abnormalities (Jeziorkowska et al, 2015). Therefore, it is necessary to find new, effective therapies with fewer side effects for the treatment of AD.…”
Section: Introductionmentioning
confidence: 99%
“…As a standard therapy for the treatment of AD, topical or systemic steroids and antihistamines are administered in combination with immunosuppressive agents and antibiotics (Schäkel et al, 2014). However, these long-term remedies are not effective in many AD patients due to severe side effects, such as tolerability, metabolic abnormalities, increased infection, and endocrine abnormalities (Jeziorkowska et al, 2015). Therefore, it is necessary to find new, effective therapies with fewer side effects for the treatment of AD.…”
Section: Introductionmentioning
confidence: 99%
“…As illustrated in Figure 1a, C-K, F2, G75, PPD, PPT, Rg3, and Rh2 significantly inhibited the production of TSLP in response to TNF-α and Poly I:C. Furthermore, C-K, PPD, Rc, and Rh2 markedly decreased the levels of IL-8 compared with stimulated cells. The ginsenoside Rh2 exhibited the most potent inhibitory effects against the production of both TSLP and IL-8 in similar levels to dexamethasone (DEX), which is widely used in the treatment of AD [26] ( Figure 1A-C). Rh2 was thus chosen as the candidate for subsequent experiments.…”
Section: Rh2 Attenuated Inflammatory Cytokines In Stimulated Nhksmentioning
confidence: 98%
“…The risk of adverse effects is also linked to the chemical structure of GCs, and the excipient used in the formulation. The most potent absorption can be achieved with ointments (27) . Hypercortisolism leads to a number of changes in appearance and skin complications.…”
Section: Adverse Reactionsmentioning
confidence: 99%