Topical sirolimus in facial angiofibroma

Gajjar, Prachi Chetankumar; Mehta, Hita; Barvaliya, Manish; Lakhotia, Rahul

doi:10.4103/ijdd.ijdd_21_18

Cited by 7 publications

(21 citation statements)

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“…There is evidence available to suggest that topical growth factor formulations are both safe and effective for skin rejuvenation. 14,15,17,18 However, the precise mechanism of action of these…”

Section: Discussionmentioning

confidence: 99%

Improvements in skin quality parameters in postmenopausal participants after use of topical growth factor serum

Gold

Wilson

Makino

et al. 2022

J of Cosmetic Dermatology

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Background Photodamage can induce skin aging processes that can be particularly concerning for postmenopausal women. Growth factors from hypoxic human fibroblast‐conditioned media have demonstrated improvements in skin quality parameters. Aims The aim of the study was to assess efficacy and tolerability of topical combination‐treatment hypoxic growth factor serum (TNS A+) in postmenopausal women with moderate to severe facial photodamage. Patients/Methods In this 12‐week, open‐label, single‐center study, participants used TNS A+ serum twice daily. Postmenopausal women (40–65 years of age) with Fitzpatrick skin types I–VI and modified Griffiths scale scores 4–9 were eligible. Clinical and participant‐reported assessments were evaluated at Weeks 6 and 12. Statistical significance was defined as p ≤ 0.05. Results There were 17 enrolled participants. TNS A+ treatment demonstrated significant improvements from baseline in fine lines and wrinkles in periocular, forehead, and cheek areas at Week 12 and the perioral area at Weeks 6 and 12. Significant improvements from baseline in coarse lines and wrinkles were observed for the perioral area at Week 12 and periocular and cheek areas at Weeks 6 and 12. Improvements in overall photodamage, skin tone evenness, and tactile roughness were significantly greater at Weeks 6 and 12 versus baseline. Most participants reported TNS A+ made their skin look and feel smooth, soft, and rejuvenated; improved skin radiance; made lines and wrinkles less apparent; and improved skin texture. No treatment‐related adverse events were reported. Conclusions The TNS A+ regimen was well tolerated and provided significant improvements in skin quality in postmenopausal women with moderate to severe facial photodamage.

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Section: Discussionmentioning

confidence: 99%

Improvements in skin quality parameters in postmenopausal participants after use of topical growth factor serum

Gold

Wilson

Makino

et al. 2022

J of Cosmetic Dermatology

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“…Optical profilometry using silicone impressions was used in 4 studies (2 RCT and 2 CS) (Table 2). All studies showed a statistically significant improvement in one or more of the measured parameters, including shadows due to fine lines/wrinkles, 30 periocular rhytides and coarse crow's feet lines, 48 texture irregularities and wrinkle depth, 29 skin dryness/roughness, and wrinkle depth 47 . Significant improvements in skin elasticity, as measured by a cutometer, was reported in 5 of the 6 studies that evaluated this outcome (1 RCT and 4 CS).…”

Section: Resultsmentioning

confidence: 94%

“…Two of the nine RCTs reported an improvement (numerical or statistical) with the growth factor preparation from baseline but showed no statistically significant difference in fine lines/wrinkles compared with each of their placebo controls 34,46 . Of the remaining 7 RCTs, 6 reported a statistically significant improvement in fine lines or coarse wrinkles from baseline or their placebo control 30,32,37,48,56,59 . The remaining trial showed mean improvements of 34% and 41% in wrinkles after 3 months of treatment with the two growth factor preparations but did not report any statistical analysis for the observed changes from baseline 42 .…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 summarizes the 33 identified studies and highlights study design, treatments, and methods of evaluation 29–62 . There were nine RCTs (7 double‐blind and 2 single‐blind) 30,32–34,37,42,46,48,56,59 and 24 CS studies 29,31,35,36,38–40,43–45,47,49–55,57,58,60–62 . RCTs enrolled 331 participants (317 completed) with 811 enrolled in the CS studies (748 completed).…”

Section: Resultsmentioning

confidence: 99%

“…The topical growth factor preparations included in this review are derived from a variety of sources including cultured human cells and nonhuman (animal and plant) sources. Human‐derived growth factor preparations included those derived from fibroblasts of neonatal foreskins, 29,30,32 another containing a mixture of cytokines, growth factors, and antioxidants from fetal fibroblasts, 33,34,36,37 another containing neonatal fibroblasts with multipotent behavior under conditions of hypoxia, 38–40 and another derived from human adipose tissue‐derived mesenchymal stem cells 42 . Nonhuman growth factor sources included a red deer umbilical cord lining mesenchymal stem cell extract, 46 secretions of the snail Cryptomphalus aspersa, 48,49 as well as various plants or enzymes 50–54 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Topical growth factor preparations for facial skin rejuvenation: A systematic review

Quinlan

Ghanem

Hassan

2023

J of Cosmetic Dermatology

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Fibroblast‐derived growth factors and exosomes as cosmeceuticals

Mehta,

Kadoya,

Maitra

et al. 2023

Dermatological Reviews

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IntroductionFibroblast (FB)‐derived growth factors have been successfully used in skincare to improve the appearance of aged and photodamaged skin for over 20 years. Conditioned media from FB culture, used as a source of growth factors in these early products, also contain extracellular vesicles including bioactive exosomes. Exosomes are tiny extracellular vesicles that have been isolated from the secretome of human‐derived mesenchymal stem cells (MSC), adipose‐derived stem cells, or fibroblasts for potential clinical application in wound healing, skin rejuvenation, skin disease, pigmentation, and hair growth.PurposeHere, we review the potential application of dermal FB‐derived growth factors and exosomes in maintaining the structure and function of healthy skin. Specifically, we discuss how to collect and characterize FB‐derived exosomes, formulation considerations for skincare products that may contain exosomes, and provide preliminary data to support its clinical use in improving skin quality.ResultsExosomes were successfully isolated from FB secretome and characterized for their content, markers, biological activity, and clinical effects. Condition of growth medium affected exosomes compositions and properties. Product containing 98 billion EVs /mL used twice a day for 12 weeks resulted in statistically significant improvement in all skin aging parameters tested including wrinkles, roughness, sagging and laxity.ConclusionOverall, active exosomes can be identified along with growth factors in the secretome of dermal fibroblasts and may provide an additional benefit for aging skin if its biological activity remains stable in the product formulation.

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Topical sirolimus in facial angiofibroma

Cited by 7 publications

References 0 publications

Improvements in skin quality parameters in postmenopausal participants after use of topical growth factor serum

Improvements in skin quality parameters in postmenopausal participants after use of topical growth factor serum

Topical growth factor preparations for facial skin rejuvenation: A systematic review

Fibroblast‐derived growth factors and exosomes as cosmeceuticals

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