Topical sirolimus for treatment of a solitary angiokeratoma

Abstract

Angiokeratomas are benign vascular neoplasms that arise as solitary or multiple lesions, most commonly treated with excision, electrodessication, cryotherapy, or laser therapies. This case presents a young female whose solitary angiokeratoma was treated with topical 1% sirolimus cream, improving the appearance, symptoms, and size of the lesion. Topical sirolimus cream may be a noninvasive treatment option for angiokeratomas with fewer risks than standard therapy that may be feasible and preferable for some patients.

Efficacy of mTOR inhibitors (sirolimus) in isolated limb overgrowth: a systematic review

“…As only one patient in our systematic review received topical sirolimus, we could not evaluate efficacy and tolerability of different modes of administration. Topical sirolimus has been frequently reported as an effective and safe management for different lesions, either with vascular malformations (Dodds et al, 2020) and/or vascular tumours (for example angiofibroma (Salido et al, 2012) and angiokeratoma (Camacho et al, 2020)), or without, as in psoriasis (Ormerod et al., 2005) and multiple familial trichoepitheliomas (Camacho et al., 2020). However, none of these lesions seemed to cause localized limb overgrowth.…”

Intralesional injection of triamcinolone acetonide is an effective treatment for angiokeratoma of the scrotum: a case report

“…A variety of treatments have been reported for angiokeratoma of the scrotum, including cryotherapy with liquid nitrogen, electrosurgery (such as electrocautery and electrofulguration), excision, lasers [3], sclerotherapy [4], and topical drug treatments (e.g. rapamycin cream and ethanolamine oleate) [5,6]. To our knowledge, intralesional glucocorticoid injections for angiokeratoma of the scrotum have not yet been reported in literature.…”