Topical sirolimus 1% for benign lymphangiomatous papules after radiotherapy for endometrial and breast cancers: a report of three cases

Leducq, Sophie; Gabeff, R.; Zaragoza, J.; Poiraud, C.; Tallegas, Matthias; Maruani, Annabel

doi:10.1684/ejd.2021.4000

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…Furthermore, the lesions did not recur for 24 months of follow-up. Leducq et al 9 reported that after radiotherapy for breast cancer, benign lymphangiomatous papules responded well to topical 1% sirolimus ointment. Thus, topical sirolimus is a promising treatment agent for LC.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopic Assessment of Lymphangioma Circumscriptum Treated With Topical Sirolimus Ointment: A Case Report

Ankad¹,

Smitha²,

Nagur³

2022

International Journal of Dermatology and Venereology

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Introduction: Lymphangioma circumscriptum (LC) is characterized by malformation of superficial lymphatics. Dermoscopy reveals brownish-yellow lacunae and white septa. In scrotal LC, gray and red areas are also noted. Treatment of LC is challenging because of its high recurrence.We herein report a case of scrotal LC that was successfully treated with topical sirolimus with dermoscopic assessment of the therapeutic response.Case presentation: A male patient presented with fluid-filled lesions on the scrotum after partial penectomy. Examination revealed multiple skin-colored vesicles containing serous fluid on either side of the scrotum. Dermoscopy showed brownish-yellow lacunae with white septa as specific patterns. A diagnosis of secondary LC was made based on the clinical and dermoscopic features, and the patient was treated with 0.1% topical sirolimus ointment.Discussion: Management of LC includes close follow-up. Sirolimus, by inhibiting cellular proliferation and angiogenesis, helps in the regression of vesicular lesions of LC. Furthermore, dermoscopy supports an accurate evaluation of the therapeutic response. Conclusion:Sirolimus is a promising topical agent in the treatment of LC. Dermoscopy comes handy in the evaluation of treatment response. Any residual lesions could be noted and treated accordingly.

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Section: Discussionmentioning

confidence: 99%