Topical probiotics: the unknowns behind their rising popularity

Lee, Griffin R.; Maarouf, Melody; Hendricks, Aleksi J.; Lee, Dylan E.; Shi, Vivian Y.

doi:10.5070/d3255044062

Cited by 45 publications

(49 citation statements)

References 14 publications

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“…While the use of topical biotherapy dates back to 1912 when the topical application of Lactobacillus bulgaricus improved the conditions such as acne and seborrhea, the skincare industry has recently seen a surge in the topical formulations containing microorganisms [ 6 , 19 ]. Various different skincare products containing probiotics marketed globally are listed in Table 2 .…”

Section: Marketed Topical Probiotics Skin Care Productsmentioning

confidence: 99%

“…Although topical probiotics have been used to maintain a healthy skin microbiome since the beginning of the 20th century, the last decade has seen a dramatic rise in commercially available topical probiotics [ 6 ]. With the increasing popularity of these topical products and the dearth of clinical trials or efficacy studies to establish their clinical efficiency, we aimed to write a detailed review on the use of topical probiotics in treating skin disorders.…”

Section: Introductionmentioning

confidence: 99%

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Topical Probiotics: More Than a Skin Deep

et al. 2022

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Skin, an exterior interface of the human body is home to commensal microbiota and also acts a physical barrier that protects from invasion of foreign pathogenic microorganisms. In recent years, interest has significantly expanded beyond the gut microbiome to include the skin microbiome and its influence in managing several skin disorders. Probiotics play a major role in maintaining human health and disease prevention. Topical probiotics have demonstrated beneficial effects for the treatment of certain inflammatory skin diseases such as acne, rosacea, psoriasis etc., and also found to have a promising role in wound healing. In this review, we discuss recent insights into applications of topical probiotics and their influence on health and diseases of the skin. Patents, commercially available topical probiotics, and novel probiotic impregnated fabrics have been emphasized. A thorough understanding of the relationship between probiotics and the skin microbiome is important for designing novel therapeutic approaches in using topical probiotics.

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Section: Marketed Topical Probiotics Skin Care Productsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Topical Probiotics: More Than a Skin Deep

et al. 2022

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“…The relationship between topical and oral probiotics and skin health has been under focus for decades; consensus has been reached on the beneficial effects of probiotics on skin health, but the precise mechanisms of action, negative interactions with specific skin conditions or individual microbiotas, and possible contraindications, still require further elucidation [233]. Even though the great potential of skin bacteria exhibiting a marked immunomodulatory and antimicrobial activity has been shown in vitro and in vivo experiments, microbial therapies for the skin, based on such microorganisms, remain hard to develop and bring to market due to the still vast knowledge gap.…”

Section: Topical and Oral Probiotics In Skin Health And Diseases: State Of The Artmentioning

confidence: 99%

A Journey on the Skin Microbiome: Pitfalls and Opportunities

Pistone

Meroni

Panelli

et al. 2021

IJMS

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The human skin microbiota is essential for maintaining homeostasis and ensuring barrier functions. Over the years, the characterization of its composition and taxonomic diversity has reached outstanding goals, with more than 10 million bacterial genes collected and cataloged. Nevertheless, the study of the skin microbiota presents specific challenges that need to be addressed in study design. Benchmarking procedures and reproducible and robust analysis workflows for increasing comparability among studies are required. For various reasons and because of specific technical problems, these issues have been investigated in gut microbiota studies, but they have been largely overlooked for skin microbiota. After a short description of the skin microbiota, the review tackles methodological aspects and their pitfalls, covering NGS approaches and high throughput culture-based techniques. Recent insights into the “core” and “transient” types of skin microbiota and how the manipulation of these communities can prevent or combat skin diseases are also covered. Finally, this review includes an overview of the main dermatological diseases, the changes in the microbiota composition associated with them, and the recommended skin sampling procedures. The last section focuses on topical and oral probiotics to improve and maintain skin health, considering their possible applications for skin diseases.

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“…In this regard, topical bacteriotherapy was first proposed as a treatment for skin diseases in 1912, when a topical application of Lactobacillus bulgaricus was reported to have beneficial effects on acne and seborrhea [15]. Following the rise of probiotic research, numerous topical microbial formulations have been proposed in recent years to correct skin dysbiosis [16]. Topical probiotics have shown remarkable efficacy in clinical trials aimed to evaluate their effect on acne, atopic dermatitis, and rosacea [17].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

et al. 2021

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Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes. The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes, and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes. Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.

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Topical probiotics: the unknowns behind their rising popularity

Cited by 45 publications

References 14 publications

Topical Probiotics: More Than a Skin Deep

Topical Probiotics: More Than a Skin Deep

A Journey on the Skin Microbiome: Pitfalls and Opportunities

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

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