Topical photodynamic therapy in the treatment of hidradenitis suppurativa

Photodynamic therapy based on 5‐aminolevulinic acid and its use as an antimicrobial Agent

“…Other ALA vehicles with improved formulations have been shown to possess similar potential including; liposomes, gels, lotions and creams, with and without the presence of chemical enhancers . Use of these vehicles to deliver ALA could help in the treatment of hidradenitis suppurativa, or deep follicular inflammation, which has shown some improvement after the application of ALA‐based PDT and is well known for its recalcitrance to most standard therapies such as the administration of antibiotics . Other novel ALA delivery techniques with the potential to facilitate the treatment of more deep‐seated infections by ALA‐based PDT include physical penetration enhancers such as iontophoresis and needleless jet injection (NJT) .…”

“…304 Use of these vehicles to deliver ALA could help in the treatment of hidradenitis suppurativa, or deep follicular inflammation, which has shown some improvement after the application of ALA-based PDT and is well known for its recalcitrance to most standard therapies such as the administration of antibiotics. 308,309 Other novel ALA delivery techniques with the potential to facilitate the treatment of more deep-seated infections by ALA-based PDT include physical penetration enhancers such as iontophoresis and needleless jet injection (NJT). 304 Iontophoresis uses a direct electrical current to induce the passage of drugs through the skin and has been shown, in vitro, to enhance the transdermal delivery of ALA and its derivatives in the case of both porcine and human skin.…”

New topical photodynamic therapy for treatment of hidradenitis suppurativa using methylene blue niosomal gel: a single-blind, randomized, comparative study

“…Patients were screened according to their Hurley grade. 6 For each patient, half the body was treated with NMB gel and half with FMB gel. The simple method of tossing a coin was used to choose the form of gel for each side.…”

“…4,5 Nd-YAG (neodymium-doped-yttriumaluminum-garnet) laser has been used successfully for HS treatment by targeting hair follicles. 3 Previous studies using aminolaevulinic acid (ALA) as a photosensitizer have shown variable success rates in treatment of HS, [6][7][8] with differences in the success rate in these studies being attributed to insufficient penetration of the photosensitizer. 8 Moreover, a number of adverse effects have been encountered with ALA photodynamic therapy (PDT), including discomfort, burning, oedema, erythema and epidermal exfoliation.…”

Photodynamic Therapy for Malignant Skin Lesions

“…These include acne, cutaneous infections (i.e., atypical mycobacteria, leishmania), granuloma annulare, hidradenitis suppurativa, keloids, lichenoid dermatoses, lymphadenosis benigna cutis, necrobiosis lipoidica, psoriasis, rosacea, and several others (Morton et al 2013b ;Calzavara-Pinton et al 2013a , b ;Nie 2011 ;Takeda et al 2005 ;Rose and Stables 2008 ). Most fi ndings are based on anecdotal, observational, or small case series data.…”