Topical photodynamic therapy for primary cutaneous B-cell lymphoma: A pilot study

Mori, Moira; Campolmi, Piero; Mavilia, Luciano; Rossi, Riccardo; Cappugi, Pietro; Pimpinelli, Nicola

doi:10.1016/j.jaad.2005.10.016

Cited by 40 publications

(22 citation statements)

References 11 publications

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“…A recent study by Mori et al used ALA-PDT and red light at the standard dose used for BCC to treat three patients once or twice with single early cutaneous B-cell lymphoma lesions [84]. Complete remission was achieved in all three patients.…”

Section: Clinical Applications Of Pdt For Cutaneous Neoplasiamentioning

confidence: 99%

Recent advances in the prevention and treatment of skin cancer using photodynamic therapy

Zhao¹,

He²

2010

Expert Review of Anticancer Therapy

137

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Photodynamic therapy (PDT) is a noninvasive procedure that involves a photosensitizing drug and its subsequent activation by light to produce reactive oxygen species that specifically destroy target cells. Recently, PDT has been widely used in treating non-melanoma skin malignancies, the most common cancer in the USA, with superior cosmetic outcomes compared with conventional therapies. The topical 'photosensitizers' commonly used are 5-aminolevulinic acid (ALA) and its esterified derivative methyl 5-aminolevulinate, which are precursors of the endogenous photosensitizer protoporphyrin IX. After treatment with ALA or methyl 5-aminolevulinate, protoporphyrin IX preferentially accumulates in the lesion area of various skin diseases, which allows not only PDT treatment but also fluorescence diagnosis with ALA-induced porphyrins. Susceptible lesions include various forms of non-melanoma skin cancer such as actinic keratosis, basal cell carcinoma and squamous cell carcinoma. The most recent and promising developments in PDT include the discovery of new photosensitizers, the exploitation of new drug delivery systems and the combination of other modalities, which will all contribute to increasing PDT therapeutic efficacy and improving outcome. This article summarizes the main principles of PDT and its current clinical use in the management of non-melanoma skin cancers, as well as recent developments and possible future research directions.Keywords 5-aminolevulinic acid; ALA; MAL; methyl 5-aminolevulinate; PDT; photodynamic therapy; photosensitizers; skin cancer; topical PDT Skin cancer is the most common form of cancer, accounting for nearly half of all cancers in the USA [1]. The most common types of skin cancer are non-melanoma skin cancers (NMSCs): basal cell carcinoma (BCC), which forms in the basal cells, and squamous cell carcinoma (SCC), which forms in the squamous cells. BCCs are rarely fatal, but can be † Author for correspondence: Tel.: +1 773 795 4696, Fax: +1 773 702 8398, yyhe@medicine.bsd.uchicago.edu. Financial & competing interests disclosureWork in the authors' laboratories was supported by the American Skin Association, the University of Chicago Cancer Research Center (P30 CA014599), and the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript. NIH Public Access Author ManuscriptExpert Rev Anticancer Ther. Author manuscript; available in PMC 2011 September 1. Genetic factors and environmental exposure to UV radiation in sunlight or tanning beds are strong risk factors for the genesis of skin cancer. Traditional skin c...

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Section: Clinical Applications Of Pdt For Cutaneous Neoplasiamentioning

confidence: 99%

Recent advances in the prevention and treatment of skin cancer using photodynamic therapy

Zhao¹,

He²

2010

Expert Review of Anticancer Therapy

137

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“…12 In recent years, PDT has been successfully used, using topical or systemic photosensitizers, to treat superficial and nodular basal cell carcinomas, actinic keratoses, squamous cell carcinomas, Bowen's disease, cutaneous metastases of mammary cancer, Kaposi's sarcoma, cutaneous T-cell lymphomas, and cutaneous primary B-cell lymphomas. [13][14][15][16][17][18][19][20][21][22] We present an elderly man with a verrucous carcinoma of the front of his leg. As PDT has been reported active in actinic keratoses and squamous cell carcinomas, this treatment was tested in this patient with a successful outcome.…”

mentioning

confidence: 99%

Photodynamic therapy for cutaneous verrucous carcinoma

Nikkels

Thirion

Quatresooz

et al. 2007

Journal of the American Academy of Dermatology

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“…93 Other proliferative disorders, such as vascular malformations, have also been treated with impressive results, likely due to the antiangiogenic effects of PDT.…”

Section: Other Tumorsmentioning

confidence: 99%

Current Evidence and Applications of Photodynamic Therapy in Dermatology

2015

Journal of the Dermatology Nurses' Association

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Abstract:In photodynamic therapy (PDT) a photosensitizer -a molecule that is activated by light -is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.

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Topical photodynamic therapy for primary cutaneous B-cell lymphoma: A pilot study

Cited by 40 publications

References 11 publications

Recent advances in the prevention and treatment of skin cancer using photodynamic therapy

Recent advances in the prevention and treatment of skin cancer using photodynamic therapy

Photodynamic therapy for cutaneous verrucous carcinoma

Current Evidence and Applications of Photodynamic Therapy in Dermatology

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