Topical paricalcitol (19-nor-1alpha,25-dihydroxyvitamin D2) is a novel, safe and effective treatment for plaque psoriasis: a pilot study

Durakovic, C.; Ray, Swapna; Holick, Michael F.

doi:10.1111/j.1365-2133.2004.06002.x

Cited by 23 publications

(11 citation statements)

References 24 publications

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“…Vitamin D3 regulates the calcium and phosphorus levels in blood by promoting its absorption through the GI tract. Local administration of vitamin D3 indeed has a positive therapeutic effect on psoriasis [20][21][22]. The presence of phosphorus in the environment would then result in aggravation of psoriatic lesions.…”

Section: Discussionmentioning

confidence: 99%

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease, and Psoriasis in Opole Voivodship, Poland During 2000–2002

Tubek

2008

Biol Trace Elem Res

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The content of chemical elements in rainwater is a suitable indirect indicator of its presence in airborne dust, sometimes referred to as rain fallout. Rainwater is considered a suitable monitor for environmental or natural pollution. The yearly content of chemical elements in rainwater may be considered as a good indicator for determining the influence of these environmental factors on the human body. We decided to investigate the relationship between chemical elements in rainwater and the frequency of hospitalizations for arterial hypertension, chronic obstructive pulmonary disease, and psoriasis. There is a mild correlation between zinc and cadmium and cases of arterial hypertension. For obstructive pulmonary disease, there is a strong correlation with the content of potassium, calcium, iron, manganese, lead and nickel, and with chloride, sulfide, total nitrogen, and nitrites. There is also a mild correlation with magnesium, zinc, copper, cadmium and chromium, and with ammonium nitrogen. In cases of hospitalization for psoriasis, a correlation was revealed with such elements as potassium, ammonium nitrogen, and phosphorus.

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Section: Discussionmentioning

confidence: 99%

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease, and Psoriasis in Opole Voivodship, Poland During 2000–2002

Tubek

2008

Biol Trace Elem Res

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“…1,25(OH) 2 VD 3 can also block cutaneous contact hypersensitivity99, an effect that could be mediated in part by blocking the induction of skin-homing-receptor expression by lymphocytes99. Consistent with its anti-inflammatory role, a 1,25(OH) 2 VD 3 analogue has been successfully used as a therapy for psoriasis135,136. However, it should be pointed out that topical skin application of 1,25(OH) 2 VD 3 also has the potential to trigger allergic dermatitis by increasing T H 2 cell-mediated responses137.…”

Section: Vitamin Metabolites In Immunotherapymentioning

confidence: 99%

Vitamin effects on the immune system: vitamins A and D take centre stage

2008

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Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.

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“…A double-blind randomized right-left-comparison placebo-controlled study demonstrated a moderate to excellent response in patients receiving the drug [59]. The therapy was found to be well tolerated with no significant changes in calcium or phosphorous levels.…”

Section: New Topical Vitamin D Analoguesmentioning

confidence: 94%

Topical Treatment of Psoriasis

Kamili¹,

Menter²

2009

Management of Psoriasis

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Topical therapy forms the cornerstone in the management of psoriasis. Of significant value as monotherapy in mild to moderate psoriasis, it is used predominantly as adjunctive therapy in moderate and severe forms of the disease. Over the past decade, topical treatment of psoriasis has evolved from the age-old applications of tar and dithranol to the more acceptable and efficacious options of topical corticosteroids, retinoids and vitamin D analogues, with the advent of a wide range of appropriately tailored vehicles and sophisticated delivery modes. To ensure therapeutic success, proper patient education about the disease, the treatment options, their specific application modality and adverse effects is essential. This will help alleviate the common problem of poor patient adherence, and inevitably result in more optimal clinical outcomes.

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Topical paricalcitol (19-nor-1alpha,25-dihydroxyvitamin D2) is a novel, safe and effective treatment for plaque psoriasis: a pilot study

Abstract: Once-daily application of paricalcitol ointment was safe and effective for the treatment of plaque psoriasis.

Cited by 23 publications

References 24 publications

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease, and Psoriasis in Opole Voivodship, Poland During 2000–2002

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease, and Psoriasis in Opole Voivodship, Poland During 2000–2002

Vitamin effects on the immune system: vitamins A and D take centre stage

Topical Treatment of Psoriasis

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