Topical Oxymetazoline (Rhofade) in Rosacea

Nagrani, Nicole; Gonzalez, Adrianna; Zito, Patrick M.; Glick, Brad P.; Rubenstein, Richard M.

doi:10.1097/jdn.0000000000000564

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…Topical 1% oxymetazoline should now be included in the arsenal of medications for facial erythema in rosacea, as data suggest that it is an effective alternative with minimal side effects compared to previously approved topical medications. [13] Additionally, there are data to suggest that xylometazoline does not affect Eustachian tube function. Using a battery of tests to obtain objective measurements of passive and active Eustachian tube function, the results of the cited study suggest that the baseline rate of Eustachian tube opening in healthy subjects and subjects reporting symptoms of obstructive Eustachian tube dysfunction is not altered after xylometazoline is applied to the anterior nasal cavity.…”

Section: New Applications -A Reviewmentioning

confidence: 99%

Xylometazoline and oxymetazoline - unusual effects of everyday drugs (literature review)

Klas

Kluz

Piwowar

2021

J Educ Health Sport

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The aim of the study is to systematize the knowledge about xylometazoline and oxymetazoline - commonly used nasal sprays with sympathicomimetic effect, mainly directly on α-adrenergic receptors [1]. A review of recent reports on possible side effects and new therapeutic options will be presented. Results: Over several years, reports have been published regarding descriptions of unusual cases of side effects, such as angina attack [4], a case of respiratory failure in a newborn [5], ischemic stroke [6], or anaphylactic reaction during routine surgery. In experiments using rats, on the other hand, it has been shown that these substances can also cause increased inflammation of the lower respiratory tract [7], as well as numerous ophthalmic problems [8]. Recent reports also suggest new uses for xylometazoline and oxymetazoline. In combination with lidocaine, an intranasal solution of xylometazoline has shown efficacy in the anesthesia of maxillary teeth in patients with minor carious lesions [9], and a beneficial therapeutic combination of oxymetazoline and dye laser (PDL) has also been reported for the treatment of rosacea, among others [10]. Conclusions: Although imidazoline derivatives were admitted to the drug list decades ago, still their pharmacological potential has not been fully exploited. Finding applications of these drugs in dermatology and dentistry may not only improve the efficacy and comfort of treatment, but also significantly reduce the costs of the whole therapy. The aforementioned reports on the side effects of xylometazoline and oxymetazoline should not be forgotten. It is possible that the presented examples will increase awareness to use these drugs with more respect, according to the recommendations on the leaflet.

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Section: New Applications -A Reviewmentioning

confidence: 99%