Topical Ofloxacin Treatment of Otorrhea in Children With Tympanostomy Tubes

Abstract

Ofloxacin is safe and significantly more effective than treatments used in historical or current practice for acute purulent otorrhea in children with tympanostomy tubes.

Topical Ciprofloxacin/Dexamethasone Otic Suspension is Superior to Ofloxacin Otic Solution in the Treatment of Granulation Tissue in Children with Acute Otitis Media With Otorrhea Through Tympanostomy Tubes

“…Both ciprofloxacin and ofloxacin, when used alone as topical otic preparations, are effective for the treatment of AOMT in children, with no apparent risk of ototoxicity with either agent 15-17,20 . In the present study we show that the addition of the corticosteroid, dexamethasone, to the fluoro-quinolone, ciprofloxacin, achieves superior rates of eradication of granulation tissue compared with treatment with the single agent fluoroquinolone, ofloxacin.…”

Treatment of Chronic Suppurative Otitis Media With Topical Tobramycin and Dexamethasone

“…25 In a study of children with acute purulent otorrhea, topical ofloxacin demonstrated an 84.4% cure in subjects evaluated clinically, and it eradicated 96.3% of all baseline pathogens in subjects evaluated microbiologically. 2 Our study clearly demonstrates an added benefit of dexamethasone when combined with tobramycin for resolving otorrhea and eradicating P aeruginosa. The duration of treatment necessary to achieve complete eradication of P aeruginosa from the ears were 3, 5.5, and 6 weeks for groups 2, 3, and 1, respectively.…”

Topical Ciprofloxacin/Dexamethasone Otic Suspension Is Superior to Ofloxacin Otic Solution in the Treatment of Children With Acute Otitis Media With Otorrhea Through Tympanostomy Tubes

“…4,5,16,17 The present study shows that the addition of the corticosteroid dexamethasone to the fluoroquinolone ciprofloxacin achieves superior rates of clinical cure and microbiologic success, results in fewer treatment failures, and provides earlier resolution of AOMT compared with treatment with the single-agent fluoroquinolone ofloxacin. In this regard, the findings confirm our earlier clinical report of ciprofloxacin/dexamethasone versus ciprofloxacin 15 and in experimental animal studies showing that antibiotic/dexamethasone combinations are more effective than antibiotic therapy alone in resolving otorrhea in a primate model of CSOM 14 and in reducing and preventing persistent middle ear mucosal changes in rats with experimental AOM.…”