Topical NSAIDs Effect on Corneal Sensitivity

Abstract

All 4 currently available NSAIDs demonstrated anesthetic effects similar to brand diclofenac and brand ketorolac.

The effects of topical diclofenac, topical flurbiprofen, and humidity on corneal sensitivity in normal dogs

“…The data presented in this study indicates that neither topical diclofenac nor flurbiprofen has an effect on corneal sensitivity in normal, nonbrachycephalic dogs after multiple‐drop dosing or chronic, twice‐daily dosing for 30 days. This is in direct contrast to humans in which topical diclofenac has been shown to decrease corneal sensitivity after single and multiple doses . Of importance to the present study, evaluation in humans has shown that diclofenac consistently decreases corneal sensitivity while flurbiprofen does not have the same effect .…”

“…In humans, topical NSAIDs have been shown to decrease corneal sensitivity . Additionally, topical NSAIDs have been shown to attenuate corneal nerve responses in cats .…”

“…Most importantly, diabetic patients undergoing cataract surgery frequently have tear film disorders that predispose them to corneal ulceration . With the decrease in corneal sensitivity due to diabetes mellitus, the long‐term postoperative management with a topical NSAIDs may potentiate corneal ulceration or lead to delayed wound healing due to altered neurotrophic influence, as seen in humans and cats . Therapeutic strategies for ocular inflammatory disorders are constantly evolving with the development of new drugs, and the benefit of ameliorating pain by decreasing corneal sensitivity must not overshadow potential effects on neural input and corneal wound healing.…”

Bromfenac Ophthalmic Solution 0.07 %: A Review of Its Use After Cataract Surgery

“…In 10 healthy volunteers, bromfenac 0.07 % (administered as one drop every 5 min for a total of four drops) significantly (p \ 0.001) reduced corneal sensitivity versus baseline [11]. Limited data (from an abstract) from 24 patients (38 eyes) participating in a pilot study following cataract surgery showed that therapy with bromfenac 0.07 % once daily plus loteprednol etabonate 0.05 % taper plus besifloxacin 0.6 % three-times daily minimized macular thickening [12].…”

Association Between Meibomian Gland Testing and Ocular Surface Sensitivity

“…In addition, the sensations experienced at the ocular surface are difficult to quantify in each subject because sensation perception can be affected by several factors including medications, systemic conditions, and the environment. 17,19,[42][43][44][45] Even the various receptors discussed previously (mechanoreceptors, polymodal receptors, and cold receptors) have been shown to affect each other. 46,47 These factors may need to be considered together to fully understand the association between the tear-producing glands and the ocular surface sensations.…”