Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions

Wakai, Abel; Lawrenson, John G; Lawrenson, Annali L; Wang, Yongjun; Brown, Michael D.; Quirke, Michael; Ghandour, Omar; McCormick, Ryan C.; Walsh, Cathal; Amayem, Ahmed; Lang, Eddy; Harrison, Nick

doi:10.1002/14651858.cd009781.pub2

Cited by 21 publications

(15 citation statements)

References 30 publications

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“…NSAID eye drop preparations are commonly used by ophthalmologists and are well tolerated. 39,40 In the context of corneal graft healing, some NSAIDs, in particular nepafenac, slowed epithelial healing. 41 Corneal dystrophy patients suffer pain and inflammation 42 and NSAIDs would potentially provide additional beneficial symptomatic relief.…”

Section: Discussionmentioning

confidence: 99%

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Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

Kumari

Casey

2018

Invest. Ophthalmol. Vis. Sci.

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Citation: Alka K, Casey JR. Ophthalmic nonsteroidal anti-inflammatory drugs as a therapy for corneal dystrophies caused by SLC4A11 mutation. Invest Ophthalmol Vis Sci. 2018;59:4258-4267. https://doi.org/ 10.1167/iovs.18-24301 PURPOSE. SLC4A11 is a plasma membrane protein of corneal endothelial cells. Some mutations of the SLC4A11 gene result in SLC4A11 protein misfolding and failure to mature to the plasma membrane. This gives rise to some cases of Fuchs' endothelial corneal dystrophy (FECD) and congenital hereditary endothelial dystrophy (CHED). We screened ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) for their ability to correct SLC4A11 folding defects.METHODS. Five ophthalmic NSAIDs were tested for their therapeutic potential in some genetic corneal dystrophy patients. HEK293 cells expressing CHED and FECD-causing SLC4A11 mutants were grown on 96-well dishes in the absence or presence of NSAIDs. Ability of NSAIDs to correct mutant SLC4A11 cell-surface trafficking was assessed with a bioluminescence resonance energy transfer (BRET) assay and by confocal microscopy. The ability of mutant SLC4A11-expressing cells to mediate water flux (SLC4A11 mediates water flux across the corneal endothelial cell basolateral membrane as part of the endothelial water pump) was measured upon treatment with ophthalmic NSAIDs.RESULTS. BRET-assays revealed significant rescue of SLC4A11 mutants to the cell surface by 4 of 5 NSAIDs tested. The NSAIDs, diclofenac and nepafenac, were effective in moving endoplasmic reticulum-retained missense mutant SLC4A11 to the cell surface, as measured by confocal immunofluorescence. Among intracellular-retained SLC4A11 mutants, 20 of 30 had significant restoration of cell surface abundance upon treatment with diclofenac. Diclofenac restored mutant SLC4A11 water flux activity to the level of wild-type SLC4A11 in some cases.CONCLUSIONS. These results encourage testing diclofenac eye drops as a treatment for corneal dystrophy in patients whose disease is caused by some SLC4A11 missense mutations.

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Section: Discussionmentioning

confidence: 99%

“…These include analgesia following corneal abrasion, 39 schleritis, 48 and anterior chamber inflammation following cataract surgery. 40 All of the ophthalmic NSAIDs used in this report were effective in reducing anterior chamber inflammation, with diclofenac revealed as most effective.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

Kumari

Casey

2018

Invest. Ophthalmol. Vis. Sci.

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“…Cycloplegics can prevent ciliary spasm associated with corneal abrasion. [8] Non-Steroid Anti Inflammatory Drugs (NSAIDs) [6] should be given in cases of pain. There is no evidence that topical NSAIDs are better than oral NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

Good Visual Acuity Outcome from an Ocular Blast Injury with Proper Management in Dr. Soetomo General Hospital Surabaya, Indonesia

Nurfahri

Lutfi

Zuhria

2021

VSEHJ

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Introduction: Ocular blast injury related to fireworks most often causing corneal erosion (29%), conjunctival erosion (11%), and conjunctival foreign body (10%) with children are more often than adults (65.9%:34.1%), and males far more often than female (71.9%:28.1%). Knowing proper management is very important to achieve the best result. Case presentation: We describe an ocular blast injury that experienced broad erosion and multiple foreign bodies on the corneal and pericorneal surface in the left eye and visual acuity decreased. The foreign body was scattered, and the fluorescein test was positive. We did proper foreign body extraction, irrigation, and ocular bandage. It was treated with chloramphenicol 0.5% eye ointment and homatropine eye drop. In two months, the patient’s left eye had clear cornea with a small scar formation near the visual axis. The visual acuity was 6/7 and BCVA was 6/6 with S-0.5 C-0.5 A 50° correction. Conclusions: Patients with ocular blast injury limited to superficial cornea erosion and and conjunctival erosion have a reasonable probability of achieving the best visual acuity. Foreign body extraction, proper irrigation, and topical medication show promising results. Scar formation near the visual axis can disrupt visual acuity however can be corrected in this case it can be corrected with glasses. Furthermore, public promotion and regulation to control firework using are very important.

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“… 1 Topical nonsteroidal anti-inflammatory drugs, steroids, cycloplegics and eye patching do not improve pain or healing. 1 , 2 , 5 …”

Section: Follow-up Care Includes Oral Analgesics and Infection Preven...mentioning

confidence: 99%

Corneal foreign bodies

Ambikkumar¹,

Arthurs²,

El-Hadad³

2022

CMAJ

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Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions

Abstract: Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions.

Cited by 21 publications

References 30 publications

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

Good Visual Acuity Outcome from an Ocular Blast Injury with Proper Management in Dr. Soetomo General Hospital Surabaya, Indonesia

Corneal foreign bodies

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