Topical nasal steroids for intermittent and persistent allergic rhinitis in children

Sayyad, JJ Al; Alhashimi, Dunia; Fedorowicz, Zbys; Jamal, Ahmed

doi:10.1002/14651858.cd003163.pub3

Cited by 14 publications

(22 citation statements)

References 20 publications

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“…An advantage of assessing knemometry to evaluate the effect of intranasal steroids on growth include the relatively easy ability to observe short periods of growth in children, which then enables investigators to design trials using crossover designs and randomized controlled clinical trials. To date, there has only been 1 systematic review evaluating topical nasal steroids for intermittent and persistent allergic rhinitis in children . This study did not demonstrate or report adverse events in any of the 3 trials, finding that the data analysis was flawed in 2 of the trials and incomprehensible in the third …”

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

Topical intranasal corticosteroids and growth velocity in children: a meta‐analysis

Mener

Shargorodsky

Varadhan

et al. 2014

Int Forum Allergy Rhinol

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Section: Discussionmentioning

confidence: 82%

“…To date, there has only been 1 systematic review evaluating topical nasal steroids for intermittent and persistent allergic rhinitis in children . This study did not demonstrate or report adverse events in any of the 3 trials, finding that the data analysis was flawed in 2 of the trials and incomprehensible in the third …”

Section: Discussionmentioning

confidence: 82%

Topical intranasal corticosteroids and growth velocity in children: a meta‐analysis

Mener

Shargorodsky

Varadhan

et al. 2014

Int Forum Allergy Rhinol

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show abstract

“…22 A Cochrane review published in 2007 specifically evaluating the use of intranasal steroids in children with AR was severely limited by the exclusion of trials that included predominantly adults or permitted the use of rescue medication. 23 Nonetheless, a number of meta-analyses have provided robust evidence for their use in this age group and have demonstrated significant efficacy against nasal symptoms and, in particular, nasal blockage. 24,25 Prophylactic use prior to the pollen season has also been shown to improve severity of symptoms, 10 though intranasal steroids are not licensed for this use in children under 12 years.…”

Section: Intranasal Corticosteroidsmentioning

confidence: 99%

Allergic rhinitis in children

Turner

Kemp

2012

J Paediatrics Child Health

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Allergic rhinitis affects up to 40% of children but is commonly undiagnosed. Careful assessment of nasal symptoms allows for the most appropriate therapeutic options to be chosen. Allergen avoidance is often difficult in practice. Antihistamines are of limited benefit in allergic rhinitis caused by house dust mite and other perennial allergens, where symptoms, predominantly nasal obstruction, are not histamine mediated. In contrast, symptoms triggered by pollen, such as nasal itch, rhinorrhoea and sneezing, are relieved by antihistamines. Intranasal steroids are the treatment of choice for persistent moderate–severe allergic rhinitis and are more effective than antihistamines for relief of nasal obstruction. Failure to respond to intranasal medications is often caused by poor compliance or inefficient use of nasal sprays. Immunotherapy may be a useful, if expensive, option, particularly where symptoms are because of a specific pollen. The benefits of immunotherapy in house dust mite‐induced rhinitis and asthma remain controversial.

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“…This was mainly from the lack and poor quality data included in the trials with no reliable evidence on the effectiveness of BeclomethasoneDipropionate or flunisolide. Thus, the authors suggestedfurther research is needed on this topic [28].…”

Section: Intranasal Corticosteroidsmentioning

confidence: 99%