“…Topical MMC 0.02% or 0.04% 4 times daily in 7 to 14-day for two cycles have been successfully employed for preoperative chemoreduction and to manage recurrent and residual tumors following surgical resection (Shields et al, 2002), (Frucht-Pery et al, 2002), (Shields et al,2005). MMC had been effectively used to treat primary CIN, with reported success rates between 85% (Wilson et al, 1997) and 100% (Frucht-Pery & Rozenmam, 1994), (Ramos-Lopez et al, 2004).…”