Topical metronidazole in the treatment of perioral dermatitis

Veien, Niels K.; Munkvad, Jan Mikael; Nielsen, Aksel Otkjaer; Niordson, Ann-Marie; Stahl, Dorrit; Thormann, Jens

doi:10.1016/0190-9622(91)70038-4

Cited by 55 publications

(65 citation statements)

References 8 publications

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“…We found 30 studies [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] to contain at least partly appropriate information about the treatment of POD (table 3). The quality evaluation based on principles of evidence-based medicine [36] only revealed 2 studies with a medium-range score of 4 [5, 6] and the remaining 28 studies with scores between 0.5 and 2.5 (tables 1, 3) which we regarded to be of low quality.…”

Section: Resultsmentioning

confidence: 99%

“…A reasonable statistical analysis was not possible because of lack of pertinent data and the low level of evidence found in most papers [4,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] and since the 2 papers with medium-range quality [5, 6] were different in several respects. …”

Section: Methodsmentioning

confidence: 99%

“…Up to February 2004, sources for this study were Medline (1964–2004), Embase (1966–2004), the Central Register of Controlled Clinical Trials (Central) of the Cochrane Library (1971–2004) and the 526 references of 3 textbook articles [1,2,3], the 30 papers cited in this study [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] and 2 recent reviews [34, 35]. In Medline and Embase, 125 out of 215 and 296 out of 454 articles, respectively, were found referring to ‘perioral (and) dermatitis and therapy’.…”

Section: Methodsmentioning

confidence: 99%

“…In the Cochrane Central, only 6 out of 8 articles referred to treatment of POD [[5, 6, 11, 12, 27, 28]. For Medline/Embase, the selection process was as follows: from 125/296 articles, 36/160 articles were excluded in a first step (28/105 with diagnoses other than POD, 8/42 dealing with corticosteroids, 0/13 dealing with therapeutics in general) amounting to 89/136 papers; excluded were 64/107 additional articles (36/51 referring to non-therapeutic aspects of POD, 5/12 describing patients with granulomatous POD, 16/33 with languages other than English or German, 7/9 small series and case reports of POD, 0/2 other publications: a paper by A.F.…”

Section: Methodsmentioning

confidence: 99%

“…Some dermatologists recommend no therapy [1, 4]. The discontinuation of topical corticosteroids and cosmetics is said to be important [1,2,3,4,5,6,7,8]. However, several problems are encountered.…”

Section: Introductionmentioning

confidence: 99%

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Critical Appraisal of Reports on the Treatment of Perioral Dermatitis

Weber¹,

Thurmayr

2005

Dermatology

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Background: Presently, problems exist with the rationale of oral therapy and the nature and indication of topical and accompanying treatment of perioral dermatitis. Objective: Providing the basis to overcome these problems by a quality evaluation of treatment reports and assessment of the consistency of treatment experience. Methods: Sources were Medline (1964–2004), Embase (1966–2004), the Cochrane Central (1971–2004) and 526 ref erences of 3 textbooks, 2 recent reviews and 30 papers on perioral dermatitis. Thirty English and German articles were selected. These studies were evaluated according to principles of evidence-based medicine and related criteria. Evaluation of 28 papers was carried out by the authors and of our own 2 papers by 2 other reviewers. Consistency of results was qualitatively assessed by the authors. Results: There wereonly 2 therapeutic trials of medium-range quality. The other studies were of low quality. Consistency was noted concerning treatment with oral tetracycline (with 1 exception), discontinuation of topical corticosteroids and cosmetics and, to a lesser extent, regarding no therapy. There was inconsistency in respect to topical therapy. Conclusion: The presented data help to interpret and conduct studies on the treatment of perioral dermatitis.

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